Drug Release Kinetics from Tablet Matrices Based Upon Ethylcellulose Ether-Derivatives: A Comparison Between Different Formulations

ABSTRACT The present study involved the preparation of ibuprofen-containing controlled release tablets formulated from either the established granular product, Ethocel®Standard Premium, or the novel finely-milled product, Ethocel®Standard FP Premium. The tablets were prepared by either direct compre...

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Veröffentlicht in:	Drug development and industrial pharmacy 2007-06, Vol.33 (6), p.627-639
Hauptverfasser:	Khan, Gul Majid, Meidan, Victor M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - chemistry Biological and medical sciences Cellulose - analogs & derivatives Cellulose - chemistry Chemistry, Pharmaceutical Controlled-release matrices Delayed-Action Preparations Ethers Ethocel® polymers Excipients - chemistry General pharmacology Ibuprofen Ibuprofen - chemistry Kinetic models Kinetics Lactose - analogs & derivatives Lactose - chemistry Medical sciences Methylcellulose - analogs & derivatives Methylcellulose - chemistry Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Release mechanisms Solubility Tablets Viscosity
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