A case of theophylline-induced hypercalcemia
We report a case of theophylline-induced hypercalcemia. The patient, a 51-year-old women, had been administered theophylline for about five years because of bronchial asthma. She was referred to us in March 2003 for the treatment of renal failure and hypercalcemia (15.2mg/dL), which had been increas...
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| Veröffentlicht in: | Nihon Jinzo Gakkai shi 2007/05/25, Vol.49(4), pp.446-451 |
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| container_issue | 4 |
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| container_title | Nihon Jinzo Gakkai shi |
| container_volume | 49 |
| creator | ITOH, Yoko TSURUMI, Yuko KIMURA, Toshihiro TAKESHITA, Yasuyo TOKITA, Yasuo TOYA, Yoshiyuki UMEMURA, Satoshi |
| description | We report a case of theophylline-induced hypercalcemia. The patient, a 51-year-old women, had been administered theophylline for about five years because of bronchial asthma. She was referred to us in March 2003 for the treatment of renal failure and hypercalcemia (15.2mg/dL), which had been increasing since 2001. Clinical and laboratory findings were not consistent with any endocrinopathy. We suspected drug-induced hypercalcemia. Three months after discontinuation of theophylline therapy, the hypercalcemia was completely cured. When admitted to our hospital, the patient was diagnosed as also having Hashimoto's disease. Hyperthyroidism might enhance the effect of theophylline on parathyroid hormone action. Therefore, theophylline induced hypercalcemia even though she was taking the therapeutic level. Moreover, her calcium excretion did not increase despite hypercalcemia. We concluded that her hypercalcemia was induced by theophylline and hyperthyroidism, and that hypocalciuria might have enhanced these conditions. |
| doi_str_mv | 10.14842/jpnjnephrol1959.49.446 |
| format | Article |
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The patient, a 51-year-old women, had been administered theophylline for about five years because of bronchial asthma. She was referred to us in March 2003 for the treatment of renal failure and hypercalcemia (15.2mg/dL), which had been increasing since 2001. Clinical and laboratory findings were not consistent with any endocrinopathy. We suspected drug-induced hypercalcemia. Three months after discontinuation of theophylline therapy, the hypercalcemia was completely cured. When admitted to our hospital, the patient was diagnosed as also having Hashimoto's disease. Hyperthyroidism might enhance the effect of theophylline on parathyroid hormone action. Therefore, theophylline induced hypercalcemia even though she was taking the therapeutic level. Moreover, her calcium excretion did not increase despite hypercalcemia. We concluded that her hypercalcemia was induced by theophylline and hyperthyroidism, and that hypocalciuria might have enhanced these conditions.</description><identifier>ISSN: 0385-2385</identifier><identifier>EISSN: 1884-0728</identifier><identifier>DOI: 10.14842/jpnjnephrol1959.49.446</identifier><identifier>PMID: 17578191</identifier><language>jpn</language><publisher>Japan: Japanese Society of Nephrology</publisher><subject>Asthma - drug therapy ; Bronchodilator Agents - adverse effects ; drug-induced ; Female ; Hashimoto Disease - complications ; Hashimoto's disease ; Humans ; hypercalcemia ; Hypercalcemia - chemically induced ; hyperthyroidism ; Hyperthyroidism - complications ; Middle Aged ; theophylline ; Theophylline - adverse effects</subject><ispartof>The Japanese Journal of Nephrology, 2007/05/25, Vol.49(4), pp.446-451</ispartof><rights>Japanese Society of Nephrology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17578191$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ITOH, Yoko</creatorcontrib><creatorcontrib>TSURUMI, Yuko</creatorcontrib><creatorcontrib>KIMURA, Toshihiro</creatorcontrib><creatorcontrib>TAKESHITA, Yasuyo</creatorcontrib><creatorcontrib>TOKITA, Yasuo</creatorcontrib><creatorcontrib>TOYA, Yoshiyuki</creatorcontrib><creatorcontrib>UMEMURA, Satoshi</creatorcontrib><title>A case of theophylline-induced hypercalcemia</title><title>Nihon Jinzo Gakkai shi</title><addtitle>Jpn J Nephrol</addtitle><description>We report a case of theophylline-induced hypercalcemia. The patient, a 51-year-old women, had been administered theophylline for about five years because of bronchial asthma. She was referred to us in March 2003 for the treatment of renal failure and hypercalcemia (15.2mg/dL), which had been increasing since 2001. Clinical and laboratory findings were not consistent with any endocrinopathy. We suspected drug-induced hypercalcemia. Three months after discontinuation of theophylline therapy, the hypercalcemia was completely cured. When admitted to our hospital, the patient was diagnosed as also having Hashimoto's disease. Hyperthyroidism might enhance the effect of theophylline on parathyroid hormone action. Therefore, theophylline induced hypercalcemia even though she was taking the therapeutic level. Moreover, her calcium excretion did not increase despite hypercalcemia. We concluded that her hypercalcemia was induced by theophylline and hyperthyroidism, and that hypocalciuria might have enhanced these conditions.</description><subject>Asthma - drug therapy</subject><subject>Bronchodilator Agents - adverse effects</subject><subject>drug-induced</subject><subject>Female</subject><subject>Hashimoto Disease - complications</subject><subject>Hashimoto's disease</subject><subject>Humans</subject><subject>hypercalcemia</subject><subject>Hypercalcemia - chemically induced</subject><subject>hyperthyroidism</subject><subject>Hyperthyroidism - complications</subject><subject>Middle Aged</subject><subject>theophylline</subject><subject>Theophylline - adverse effects</subject><issn>0385-2385</issn><issn>1884-0728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLw1AUhC-i2FD7FzQ_wNT7OPe1LMUXFtzoOtzHiUlIk5Cki_57A61dCMMMHD4OwxDywOiagQH-VPdt3WJfDl3DrLRrmAXqiiTMGMio5uaaJFQYmfHZFmQ1jpWnzGgqpIZbsmBaasMsS8jjJg1uxLQr0qnEri-PTVO1mFVtPASMaXnscQiuCbiv3B25KVwz4uqcS_L98vy1fct2n6_v280uqzkzUyasAcW80hy5K0D76GQspBIi2qC8dxKoVkwiADXWGxrNfEGGNnhurRZLcn_62x_8HmPeD9XeDcf8r_YMfJyAepzcD14AN0xVaDD_N1AOs84G6kKF0g05tuIXLb5jEw</recordid><startdate>2007</startdate><enddate>2007</enddate><creator>ITOH, Yoko</creator><creator>TSURUMI, Yuko</creator><creator>KIMURA, Toshihiro</creator><creator>TAKESHITA, Yasuyo</creator><creator>TOKITA, Yasuo</creator><creator>TOYA, Yoshiyuki</creator><creator>UMEMURA, Satoshi</creator><general>Japanese Society of Nephrology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>2007</creationdate><title>A case of theophylline-induced hypercalcemia</title><author>ITOH, Yoko ; TSURUMI, Yuko ; KIMURA, Toshihiro ; TAKESHITA, Yasuyo ; TOKITA, Yasuo ; TOYA, Yoshiyuki ; UMEMURA, Satoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j218t-398461b672e2af47bda5df5633d9c6bba5407615e44089b80d8540e1e9cb29973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>2007</creationdate><topic>Asthma - drug therapy</topic><topic>Bronchodilator Agents - adverse effects</topic><topic>drug-induced</topic><topic>Female</topic><topic>Hashimoto Disease - complications</topic><topic>Hashimoto's disease</topic><topic>Humans</topic><topic>hypercalcemia</topic><topic>Hypercalcemia - chemically induced</topic><topic>hyperthyroidism</topic><topic>Hyperthyroidism - complications</topic><topic>Middle Aged</topic><topic>theophylline</topic><topic>Theophylline - adverse effects</topic><toplevel>online_resources</toplevel><creatorcontrib>ITOH, Yoko</creatorcontrib><creatorcontrib>TSURUMI, Yuko</creatorcontrib><creatorcontrib>KIMURA, Toshihiro</creatorcontrib><creatorcontrib>TAKESHITA, Yasuyo</creatorcontrib><creatorcontrib>TOKITA, Yasuo</creatorcontrib><creatorcontrib>TOYA, Yoshiyuki</creatorcontrib><creatorcontrib>UMEMURA, Satoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Nihon Jinzo Gakkai shi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ITOH, Yoko</au><au>TSURUMI, Yuko</au><au>KIMURA, Toshihiro</au><au>TAKESHITA, Yasuyo</au><au>TOKITA, Yasuo</au><au>TOYA, Yoshiyuki</au><au>UMEMURA, Satoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case of theophylline-induced hypercalcemia</atitle><jtitle>Nihon Jinzo Gakkai shi</jtitle><addtitle>Jpn J Nephrol</addtitle><date>2007</date><risdate>2007</risdate><volume>49</volume><issue>4</issue><spage>446</spage><epage>451</epage><pages>446-451</pages><issn>0385-2385</issn><eissn>1884-0728</eissn><abstract>We report a case of theophylline-induced hypercalcemia. The patient, a 51-year-old women, had been administered theophylline for about five years because of bronchial asthma. She was referred to us in March 2003 for the treatment of renal failure and hypercalcemia (15.2mg/dL), which had been increasing since 2001. Clinical and laboratory findings were not consistent with any endocrinopathy. We suspected drug-induced hypercalcemia. Three months after discontinuation of theophylline therapy, the hypercalcemia was completely cured. When admitted to our hospital, the patient was diagnosed as also having Hashimoto's disease. Hyperthyroidism might enhance the effect of theophylline on parathyroid hormone action. Therefore, theophylline induced hypercalcemia even though she was taking the therapeutic level. Moreover, her calcium excretion did not increase despite hypercalcemia. We concluded that her hypercalcemia was induced by theophylline and hyperthyroidism, and that hypocalciuria might have enhanced these conditions.</abstract><cop>Japan</cop><pub>Japanese Society of Nephrology</pub><pmid>17578191</pmid><doi>10.14842/jpnjnephrol1959.49.446</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Japanese Journal of Nephrology, 2007/05/25, Vol.49(4), pp.446-451 |
| issn | 0385-2385 1884-0728 |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Asthma - drug therapy Bronchodilator Agents - adverse effects drug-induced Female Hashimoto Disease - complications Hashimoto's disease Humans hypercalcemia Hypercalcemia - chemically induced hyperthyroidism Hyperthyroidism - complications Middle Aged theophylline Theophylline - adverse effects |
| title | A case of theophylline-induced hypercalcemia |
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