Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo

Epoxyeicosatrienoic acids (EETs), as metabolites of arachidonic acid, may function as antihypertensive and antiatherosclerotic mediators for vasculature. EETs are degraded by soluble epoxide hydrolase (sEH). Pharmacological inhibition and genetic ablation of sEH have been shown to increase the level...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-05, Vol.104 (21), p.9018-9023
Hauptverfasser:	Ai, Ding, Fu, Yi, Guo, Deliang, Tanaka, Hiromasa, Wang, Nanping, Tang, Chaoshu, Hammock, Bruce D, Shyy, John Y.-J, Zhu, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE inhibitors Adenovirus Amino acids Angiotensin II - pharmacology Animals Antibodies Aorta - metabolism Biochemistry Biological Sciences Cattle Cells Cells, Cultured Coronary vessels Endothelium Endothelium - blood supply Endothelium - drug effects Endothelium - enzymology Enzymes Epoxide Hydrolases - genetics Epoxide Hydrolases - metabolism Gene expression Humans Hypertension Male Messenger RNA Molecular Sequence Data Plasmids Promoter regions Promoter Regions, Genetic Protein Binding Proteins Proto-Oncogene Proteins c-jun - metabolism Rats Ribonucleic acid RNA Shear stress Solubility Systolic blood pressure Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism Transfection Up-Regulation
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