Adsorption, partition and release balances of terbinafine hydrochloride, part I
In this study the adsorption, partition and releasing balances of terbinafine hydrochloride have been studied. The adsorption isotherms of antifugal drug terbinafine hydrochloride (terbinafine), on the base of its adsorption from aqueous solutions on the surface of activated charcoal, were obtained...
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| Veröffentlicht in: | Pharmazie 2007-04, Vol.62 (4), p.273-277 |
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| creator | Oremusová, J. Vitková, Z. |
| description | In this study the adsorption, partition and releasing balances of terbinafine hydrochloride have been studied. The adsorption isotherms of antifugal drug terbinafine hydrochloride (terbinafine), on the base of its adsorption from aqueous solutions on the surface of activated charcoal,
were obtained in the temperature range of 25 to 45 °C used UV VIS spectrophotometric method. The experimental data have been analyzed by Freundlich and Langmuir equations to obtain parameters describing properly this adsorption process. The thermodynamic parameters (average change molar
Gibbs energy - ΔadG0, enthalpy - ΔadH0 and entropy - ΔadS0) were calculated and compared. The partition coefficient of terbinafine hydrochloride in the system organic phase/water phase with
different organic phases (n-butyalcohol, n-hexylalcohol and n-octylalcohol) using the "shake flask" method have been studied. The experimental partition coefficient of terbinafine increased from butylalcohol to octylacohol in the partitioning system. The influence of the concentration
of polymer - hydroxy ethyl cellulose (HEC) (2-3%) used for preparation of the hydrogel (terbinafine-HEC-water), on terbinafine release has been studied. Both the concentrations of polymer and the drug had influence on the release process. |
| doi_str_mv | 10.1691/ph.2007.4.6161 |
| format | Article |
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were obtained in the temperature range of 25 to 45 °C used UV VIS spectrophotometric method. The experimental data have been analyzed by Freundlich and Langmuir equations to obtain parameters describing properly this adsorption process. The thermodynamic parameters (average change molar
Gibbs energy - ΔadG0, enthalpy - ΔadH0 and entropy - ΔadS0) were calculated and compared. The partition coefficient of terbinafine hydrochloride in the system organic phase/water phase with
different organic phases (n-butyalcohol, n-hexylalcohol and n-octylalcohol) using the "shake flask" method have been studied. The experimental partition coefficient of terbinafine increased from butylalcohol to octylacohol in the partitioning system. The influence of the concentration
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were obtained in the temperature range of 25 to 45 °C used UV VIS spectrophotometric method. The experimental data have been analyzed by Freundlich and Langmuir equations to obtain parameters describing properly this adsorption process. The thermodynamic parameters (average change molar
Gibbs energy - ΔadG0, enthalpy - ΔadH0 and entropy - ΔadS0) were calculated and compared. The partition coefficient of terbinafine hydrochloride in the system organic phase/water phase with
different organic phases (n-butyalcohol, n-hexylalcohol and n-octylalcohol) using the "shake flask" method have been studied. The experimental partition coefficient of terbinafine increased from butylalcohol to octylacohol in the partitioning system. The influence of the concentration
of polymer - hydroxy ethyl cellulose (HEC) (2-3%) used for preparation of the hydrogel (terbinafine-HEC-water), on terbinafine release has been studied. Both the concentrations of polymer and the drug had influence on the release process.</description><subject>Adsorption</subject><subject>Algorithms</subject><subject>Antifungal Agents - administration & dosage</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - pharmacokinetics</subject><subject>Cellulose - analogs & derivatives</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Pharmaceutical</subject><subject>Chemistry, Physical</subject><subject>Entropy</subject><subject>Excipients</subject><subject>Hydrogels</subject><subject>Naphthalenes - administration & dosage</subject><subject>Naphthalenes - chemistry</subject><subject>Naphthalenes - pharmacokinetics</subject><subject>Rheology</subject><subject>Solubility</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Thermodynamics</subject><issn>0031-7144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v2zAMhnXo0HZdrz0WPu20pKSkyPYxyLqtQLFe2rMgW3SiwJFcyQ7Q_vopTXYsAYIE8fIBPxi7QZijqvFu2Mw5QDmXc4UKz9glgMBZiVJesK8pbQG44qo6ZxdYykryil-yp6VNIQ6jC_5HMZg4ukNaGG-LSD2ZREVjeuNbSkXoipFi47zpnKdi82ZjaDd9iM7Ssbl4-Ma-dKZPdH2KV-zl1_3z6s_s8en3w2r5OHNC4jhTrQBSdWUWnKpFKbCR3cLKCqHG2nAOCgQhqI43XWkltHWHorbZuW24BXHFvh-5QwyvE6VR71xqqc-jUpiSLkGWglcyC29PwqnZkdVDdDsT3_T_E2TBz6PA-TX50ehtmKLPs-t12Ds9bEzcmXd9uKyGD1P8lIDUeemPUsb8_QTj2iPp8I3DM_RecS8zkCNUKDTmfm2pM1M_6tFEvX7XSYl_D_CKzA</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Oremusová, J.</creator><creator>Vitková, Z.</creator><general>Govi-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>Adsorption, partition and release balances of terbinafine hydrochloride, part I</title><author>Oremusová, J. ; Vitková, Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i341t-6c30e698a52e85731b4f5d4810919a220603e106f2bf7d40c9f139d1392db2d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adsorption</topic><topic>Algorithms</topic><topic>Antifungal Agents - administration & dosage</topic><topic>Antifungal Agents - chemistry</topic><topic>Antifungal Agents - pharmacokinetics</topic><topic>Cellulose - analogs & derivatives</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Pharmaceutical</topic><topic>Chemistry, Physical</topic><topic>Entropy</topic><topic>Excipients</topic><topic>Hydrogels</topic><topic>Naphthalenes - administration & dosage</topic><topic>Naphthalenes - chemistry</topic><topic>Naphthalenes - pharmacokinetics</topic><topic>Rheology</topic><topic>Solubility</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Thermodynamics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oremusová, J.</creatorcontrib><creatorcontrib>Vitková, Z.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmazie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oremusová, J.</au><au>Vitková, Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adsorption, partition and release balances of terbinafine hydrochloride, part I</atitle><jtitle>Pharmazie</jtitle><addtitle>Pharmazie</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>62</volume><issue>4</issue><spage>273</spage><epage>277</epage><pages>273-277</pages><issn>0031-7144</issn><abstract>In this study the adsorption, partition and releasing balances of terbinafine hydrochloride have been studied. The adsorption isotherms of antifugal drug terbinafine hydrochloride (terbinafine), on the base of its adsorption from aqueous solutions on the surface of activated charcoal,
were obtained in the temperature range of 25 to 45 °C used UV VIS spectrophotometric method. The experimental data have been analyzed by Freundlich and Langmuir equations to obtain parameters describing properly this adsorption process. The thermodynamic parameters (average change molar
Gibbs energy - ΔadG0, enthalpy - ΔadH0 and entropy - ΔadS0) were calculated and compared. The partition coefficient of terbinafine hydrochloride in the system organic phase/water phase with
different organic phases (n-butyalcohol, n-hexylalcohol and n-octylalcohol) using the "shake flask" method have been studied. The experimental partition coefficient of terbinafine increased from butylalcohol to octylacohol in the partitioning system. The influence of the concentration
of polymer - hydroxy ethyl cellulose (HEC) (2-3%) used for preparation of the hydrogel (terbinafine-HEC-water), on terbinafine release has been studied. Both the concentrations of polymer and the drug had influence on the release process.</abstract><cop>Germany</cop><pub>Govi-Verlag</pub><pmid>17484282</pmid><doi>10.1691/ph.2007.4.6161</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; IngentaConnect Free/Open Access Journals |
| subjects | Adsorption Algorithms Antifungal Agents - administration & dosage Antifungal Agents - chemistry Antifungal Agents - pharmacokinetics Cellulose - analogs & derivatives Chemical Phenomena Chemistry, Pharmaceutical Chemistry, Physical Entropy Excipients Hydrogels Naphthalenes - administration & dosage Naphthalenes - chemistry Naphthalenes - pharmacokinetics Rheology Solubility Spectrophotometry, Ultraviolet Thermodynamics |
| title | Adsorption, partition and release balances of terbinafine hydrochloride, part I |
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