Continuous inhalation of carbon monoxide induces right ventricle ischemia and dysfunction in rats with hypoxic pulmonary hypertension

1 University Francois Rabelais of Tours, IFR 135, Labpart EA 3852, Tours Cedex; and 2 Pfizer Global Research and Development, Centre de Recherche, Amboise Cedex, France Submitted 22 September 2006 ; accepted in final form 3 May 2007 We aimed to investigate the toxicity of carbon monoxide (CO) in rat...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2007-08, Vol.293 (2), p.H1046-H1052
Hauptverfasser:	Gautier, Mathieu, Antier, Daniel, Bonnet, Pierre, Net, Jean-Loic Le, Hanton, Gilles, Eder, Veronique
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals Blood Flow Velocity - drug effects Blood Pressure - drug effects Carbon monoxide Carbon Monoxide - administration & dosage Carbon Monoxide - toxicity Carboxyhemoglobin - metabolism Cardiac Catheterization Cardiovascular system Comparative analysis Coronary Circulation - drug effects Disease Models, Animal Echocardiography Fibrosis Heart Ventricles - drug effects Heart Ventricles - physiopathology Hematocrit Hypertension Hypertension, Pulmonary - blood Hypertension, Pulmonary - complications Hypertension, Pulmonary - etiology Hypertension, Pulmonary - physiopathology Hypertrophy, Right Ventricular - blood Hypertrophy, Right Ventricular - etiology Hypertrophy, Right Ventricular - physiopathology Hypoxia Hypoxia - blood Hypoxia - complications Hypoxia - physiopathology Laser-Doppler Flowmetry Life Sciences Male Myocardial Contraction - drug effects Myocardial Ischemia - chemically induced Myocardial Ischemia - complications Myocardial Ischemia - pathology Myocardial Ischemia - physiopathology Pulmonary Artery - drug effects Pulmonary Artery - physiopathology Rats Rats, Wistar Rodents Toxicity Ventricular Function, Left - drug effects Ventricular Function, Right - drug effects Ventricular Pressure - drug effects Ventricular Remodeling - drug effects
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