Analysis of the Ha-ras oncogene in C3H/He mouse liver tumours derived spontaneously or induced with diethylnitrosamine or phenobarbitone

In a study of the mechanisms involved in the induction of tumours by chemicals, the Ha-ras oncogene was analysed in liver tumours induced by the genotoxic carcinogen diethylnitrosamine (DEN), or the non-genotoxic agent phenobarbitone (PB) in C3H/He mice. Mutations were detected using the polymerase...

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Veröffentlicht in:	Carcinogenesis (New York) 1991-12, Vol.12 (12), p.2331-2336
Hauptverfasser:	RUMSBY, P. C, BARRASS, N. C, PHILLIMORE, H. E, EVANS, J. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tumors. Experimental tumors Animals Base Sequence Biological and medical sciences Blotting, Southern Codon - genetics Diethylnitrosamine DNA - genetics Experimental digestive system and abdominal tumors Gene Expression - genetics Genes, ras - genetics Immunoblotting Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - genetics Liver Neoplasms, Experimental - pathology Medical sciences Methylation Mice Mice, Inbred C3H Molecular Sequence Data Mutation Phenobarbital RNA, Neoplasm - genetics Tumors
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