Cushing's syndrome and bone mineral density : lowest Z scores in young patients
Patients with Cushing's syndrome have a high prevalence of osteoporotic fractures. Little is known about factors determining bone mineral density (BMD) in these patients. To evaluate which factors influence BMD at the time of diagnosis of Cushing's syndrome. In 77 consecutive patients with...
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| Veröffentlicht in: | Netherlands journal of medicine 2007-04, Vol.65 (4), p.137-141 |
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| creator | VAN DER EERDEN, A. W DEN HEIJER, M OYEN, W. J HERMUS, A. R |
| description | Patients with Cushing's syndrome have a high prevalence of osteoporotic fractures. Little is known about factors determining bone mineral density (BMD) in these patients.
To evaluate which factors influence BMD at the time of diagnosis of Cushing's syndrome.
In 77 consecutive patients with Cushing's syndrome with a median age of 41.1 (interquartile range 31.1 to 52.2) years we measured BMD of the lumbar spine and the femoral neck at the time of diagnosis. From the medical records we obtained information on possible predictors of BMD. We compared BMD with a reference population by means of the Z score. Adjustment for other variables than age and sex was made with linear regression models.
Patients with Cushing's syndrome had a low Z score in both the lumbar spine (-1.07 SD (95% CI -1.43 to -0.71 SD )) and in the femoral neck (-0.81 SD (95% CI -1.06 to -0.55 SD )). 82% of patients had osteopenia at one or both sites (T score lower than -1 SD ), including 31% with osteoporosis (T score -2.5 SD or lower). The main determinant of the Z score at both sites and for both sexes was age. Z score increased by about 0.4 SD per decade. 81% of patients. |
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To evaluate which factors influence BMD at the time of diagnosis of Cushing's syndrome.
In 77 consecutive patients with Cushing's syndrome with a median age of 41.1 (interquartile range 31.1 to 52.2) years we measured BMD of the lumbar spine and the femoral neck at the time of diagnosis. From the medical records we obtained information on possible predictors of BMD. We compared BMD with a reference population by means of the Z score. Adjustment for other variables than age and sex was made with linear regression models.
Patients with Cushing's syndrome had a low Z score in both the lumbar spine (-1.07 SD (95% CI -1.43 to -0.71 SD )) and in the femoral neck (-0.81 SD (95% CI -1.06 to -0.55 SD )). 82% of patients had osteopenia at one or both sites (T score lower than -1 SD ), including 31% with osteoporosis (T score -2.5 SD or lower). The main determinant of the Z score at both sites and for both sexes was age. Z score increased by about 0.4 SD per decade. 81% of patients.</description><identifier>ISSN: 0300-2977</identifier><identifier>EISSN: 1872-9061</identifier><identifier>PMID: 17452762</identifier><language>eng</language><publisher>Alphen aan den Rijn: Van zuiden</publisher><subject>Absorptiometry, Photon ; Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Adult ; Biological and medical sciences ; Bone Density - drug effects ; Bone Resorption - chemically induced ; Cushing Syndrome - chemically induced ; Cushing Syndrome - complications ; Cushing Syndrome - diagnosis ; Endocrinopathies ; Female ; Femur Neck - diagnostic imaging ; Femur Neck - pathology ; Fractures, Bone - etiology ; General aspects ; Glucocorticoids - adverse effects ; Glucocorticoids - metabolism ; Humans ; Hydrocortisone - blood ; Linear Models ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - pathology ; Male ; Medical sciences ; Middle Aged ; Netherlands ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Osteoporosis - chemically induced ; Osteoporosis - complications ; Osteoporosis - diagnosis ; Prednisone - adverse effects ; Prednisone - therapeutic use</subject><ispartof>Netherlands journal of medicine, 2007-04, Vol.65 (4), p.137-141</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18743008$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17452762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VAN DER EERDEN, A. W</creatorcontrib><creatorcontrib>DEN HEIJER, M</creatorcontrib><creatorcontrib>OYEN, W. J</creatorcontrib><creatorcontrib>HERMUS, A. R</creatorcontrib><title>Cushing's syndrome and bone mineral density : lowest Z scores in young patients</title><title>Netherlands journal of medicine</title><addtitle>Neth J Med</addtitle><description>Patients with Cushing's syndrome have a high prevalence of osteoporotic fractures. Little is known about factors determining bone mineral density (BMD) in these patients.
To evaluate which factors influence BMD at the time of diagnosis of Cushing's syndrome.
In 77 consecutive patients with Cushing's syndrome with a median age of 41.1 (interquartile range 31.1 to 52.2) years we measured BMD of the lumbar spine and the femoral neck at the time of diagnosis. From the medical records we obtained information on possible predictors of BMD. We compared BMD with a reference population by means of the Z score. Adjustment for other variables than age and sex was made with linear regression models.
Patients with Cushing's syndrome had a low Z score in both the lumbar spine (-1.07 SD (95% CI -1.43 to -0.71 SD )) and in the femoral neck (-0.81 SD (95% CI -1.06 to -0.55 SD )). 82% of patients had osteopenia at one or both sites (T score lower than -1 SD ), including 31% with osteoporosis (T score -2.5 SD or lower). The main determinant of the Z score at both sites and for both sexes was age. Z score increased by about 0.4 SD per decade. 81% of patients.</description><subject>Absorptiometry, Photon</subject><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Bone Density - drug effects</subject><subject>Bone Resorption - chemically induced</subject><subject>Cushing Syndrome - chemically induced</subject><subject>Cushing Syndrome - complications</subject><subject>Cushing Syndrome - diagnosis</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Femur Neck - diagnostic imaging</subject><subject>Femur Neck - pathology</subject><subject>Fractures, Bone - etiology</subject><subject>General aspects</subject><subject>Glucocorticoids - adverse effects</subject><subject>Glucocorticoids - metabolism</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Linear Models</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Netherlands</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Osteoporosis - chemically induced</subject><subject>Osteoporosis - complications</subject><subject>Osteoporosis - diagnosis</subject><subject>Prednisone - adverse effects</subject><subject>Prednisone - therapeutic use</subject><issn>0300-2977</issn><issn>1872-9061</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFz0FLw0AQBeBFFFurf0H2Ip4Ck02ym_UmQatQ6EUvXsp0d1JXkk3IpEj-vQErnt7l4z3emVimpVGJBZ2eiyVkAImyxizEFfMXAGhji0uxSE1eKKPVUmyrI3-GeLhnyVP0Q9eSxOjlvosk2xBpwEZ6ihzGST7IpvsmHuWHZNcNxDJEOXXHeJA9joHiyNfiosaG6eaUK_H-_PRWvSSb7fq1etwkvcrsmKDXuXKgnbNKU55BiRrIOOcUOkd1hlblkJOHGgtn0rwoSqVVof1swJbZStz-9vbHfUt-1w-hxWHa_T2bwd0JIDts6gGjC_zvSjOvQpn9APh0WEA</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>VAN DER EERDEN, A. W</creator><creator>DEN HEIJER, M</creator><creator>OYEN, W. J</creator><creator>HERMUS, A. R</creator><general>Van zuiden</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20070401</creationdate><title>Cushing's syndrome and bone mineral density : lowest Z scores in young patients</title><author>VAN DER EERDEN, A. W ; DEN HEIJER, M ; OYEN, W. J ; HERMUS, A. R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-ad642c06cc926e4308a60e7ccc2accef3a92404ed0fa5c71455826256d7cc0983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Absorptiometry, Photon</topic><topic>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Bone Density - drug effects</topic><topic>Bone Resorption - chemically induced</topic><topic>Cushing Syndrome - chemically induced</topic><topic>Cushing Syndrome - complications</topic><topic>Cushing Syndrome - diagnosis</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Femur Neck - diagnostic imaging</topic><topic>Femur Neck - pathology</topic><topic>Fractures, Bone - etiology</topic><topic>General aspects</topic><topic>Glucocorticoids - adverse effects</topic><topic>Glucocorticoids - metabolism</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Linear Models</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Netherlands</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Osteoporosis - chemically induced</topic><topic>Osteoporosis - complications</topic><topic>Osteoporosis - diagnosis</topic><topic>Prednisone - adverse effects</topic><topic>Prednisone - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAN DER EERDEN, A. W</creatorcontrib><creatorcontrib>DEN HEIJER, M</creatorcontrib><creatorcontrib>OYEN, W. J</creatorcontrib><creatorcontrib>HERMUS, A. R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Netherlands journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VAN DER EERDEN, A. W</au><au>DEN HEIJER, M</au><au>OYEN, W. J</au><au>HERMUS, A. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cushing's syndrome and bone mineral density : lowest Z scores in young patients</atitle><jtitle>Netherlands journal of medicine</jtitle><addtitle>Neth J Med</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>65</volume><issue>4</issue><spage>137</spage><epage>141</epage><pages>137-141</pages><issn>0300-2977</issn><eissn>1872-9061</eissn><abstract>Patients with Cushing's syndrome have a high prevalence of osteoporotic fractures. Little is known about factors determining bone mineral density (BMD) in these patients.
To evaluate which factors influence BMD at the time of diagnosis of Cushing's syndrome.
In 77 consecutive patients with Cushing's syndrome with a median age of 41.1 (interquartile range 31.1 to 52.2) years we measured BMD of the lumbar spine and the femoral neck at the time of diagnosis. From the medical records we obtained information on possible predictors of BMD. We compared BMD with a reference population by means of the Z score. Adjustment for other variables than age and sex was made with linear regression models.
Patients with Cushing's syndrome had a low Z score in both the lumbar spine (-1.07 SD (95% CI -1.43 to -0.71 SD )) and in the femoral neck (-0.81 SD (95% CI -1.06 to -0.55 SD )). 82% of patients had osteopenia at one or both sites (T score lower than -1 SD ), including 31% with osteoporosis (T score -2.5 SD or lower). The main determinant of the Z score at both sites and for both sexes was age. Z score increased by about 0.4 SD per decade. 81% of patients.</abstract><cop>Alphen aan den Rijn</cop><pub>Van zuiden</pub><pmid>17452762</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Netherlands journal of medicine, 2007-04, Vol.65 (4), p.137-141 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Absorptiometry, Photon Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Adult Biological and medical sciences Bone Density - drug effects Bone Resorption - chemically induced Cushing Syndrome - chemically induced Cushing Syndrome - complications Cushing Syndrome - diagnosis Endocrinopathies Female Femur Neck - diagnostic imaging Femur Neck - pathology Fractures, Bone - etiology General aspects Glucocorticoids - adverse effects Glucocorticoids - metabolism Humans Hydrocortisone - blood Linear Models Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - pathology Male Medical sciences Middle Aged Netherlands Non tumoral diseases. Target tissue resistance. Benign neoplasms Osteoporosis - chemically induced Osteoporosis - complications Osteoporosis - diagnosis Prednisone - adverse effects Prednisone - therapeutic use |
| title | Cushing's syndrome and bone mineral density : lowest Z scores in young patients |
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