Peroxisome Proliferator Activator Receptor γ Coactivator-1 Expression Is Reduced in Obesity: POTENTIAL PATHOGENIC ROLE OF SATURATED FATTY ACIDS AND p38 MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION

Peroxisome proliferator activator receptor-γ coactivator 1 (PGC-1) is a major candidate gene for diabetes-related metabolic phenotypes, contributing to decreased expression of nuclear-encoded mitochondrial genes in muscle and adipose tissue. We have demonstrated that muscle expression of PGC-1α and...

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Veröffentlicht in:	The Journal of biological chemistry 2007-05, Vol.282 (21), p.15439-15450
Hauptverfasser:	Crunkhorn, Sarah, Dearie, Farrell, Mantzoros, Christos, Gami, Hiral, da Silva, Wagner S, Espinoza, Daniel, Faucette, Ryan, Barry, Kristen, Bianco, Antonio C, Patti, Mary Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Amino Acids - pharmacology Animals Cell Line Citric Acid Cycle - drug effects Dietary Fats - pharmacology Enzyme Activation - drug effects Gene Expression Regulation - drug effects Glucosamine - pharmacology Glucose - pharmacology Histone Deacetylases - metabolism Hypoglycemic Agents - pharmacology Insulin - pharmacology MAP Kinase Signaling System - drug effects Mice Mice, Obese Mitochondrial Proteins - biosynthesis Mitochondrial Proteins - genetics Muscle Fibers, Skeletal - metabolism Obesity - genetics Obesity - metabolism Oxidative Phosphorylation - drug effects p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Palmitic Acid - pharmacology RNA, Messenger - biosynthesis RNA, Messenger - genetics Sweetening Agents - pharmacology Time Factors Transcription Factors - biosynthesis Transcription Factors - genetics Transcription, Genetic - genetics
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