Long-term effects of high iodine intake: inhibition of thyroid iodine uptake and organification in Wistar rats

To investigate the effects of chronic iodine excess on thyroid function, thyroid peroxidase (TPO) activity, and expression of sodium-iodide symporter (NIS). 500 Wistar rats were randomly exposed to 4 doses of iodine 4 microg/d (G0, control), 6 microg/d (G1), 12 microg/d (G2), and 24 microg/d (G3) fo...

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Veröffentlicht in:	Zhong hua yi xue za zhi 2006-12, Vol.86 (48), p.3420
Hauptverfasser:	Man, Na, Guan, Hai-xia, Shan, Zhong-yan, Li, Yu-shu, Fan, Chen-ling, Guo, Xiu-juan, Chen, Wei, Tong, Ya-jie, Chong, Wei, Mao, Jin-yuan, Teng, Wei-ping
Format:	Artikel
Sprache:	chi
Schlagworte:	Animals Drug Overdose Female Iodide Peroxidase - metabolism Iodine - administration & dosage Iodine - pharmacokinetics Iodine - toxicity Ion Transport - drug effects Male Random Allocation Rats Rats, Wistar Sodium - metabolism Symporters - metabolism Thyroid Gland - drug effects Thyroid Gland - metabolism Time Factors
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