Concentration Dependent Cu2+ Induced Aggregation and Dityrosine Formation of the Alzheimer's Disease Amyloid-β Peptide

The Amyloid β peptide (Aβ) of Alzheimer's diseases (AD) is closely linked to the progressive cognitive decline associated with the disease. Cu2+ ions can induce the de novo aggregation of the Aβ peptide into non-amyloidogenic aggregates and the production of a toxic species. The mechanism by wh...

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Veröffentlicht in:	Biochemistry (Easton) 2007-03, Vol.46 (10), p.2881-2891
Hauptverfasser:	Smith, David P, Ciccotosto, Giuseppe D, Tew, Deborah J, Fodero-Tavoletti, Michelle T, Johanssen, Timothy, Masters, Colin L, Barnham, Kevin J, Cappai, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Amyloid beta-Peptides - metabolism Copper - pharmacology Humans Solubility - drug effects Tyrosine - analogs & derivatives Tyrosine - metabolism
Online-Zugang:	Volltext
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