crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis

Rhomboid peptidases are members of a family of regulated intramembrane peptidases that cleave the transmembrane segments of integral membrane proteins. Rhomboid peptidases have been shown to play a major role in developmental processes in Drosophila and in mitochondrial maintenance in yeast. Most re...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-01, Vol.104 (3), p.750-754
Hauptverfasser:	Lemieux, M. Joanne, Fischer, Sarah J, Cherney, Maia M, Bateman, Katherine S, James, Michael N.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites Animals Apoptosis Atoms Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Sites Biological Sciences Cell Membrane - enzymology Coordinate systems Crystallization Crystallography, X-Ray Drosophila E coli Electron density Endopeptidases - chemistry Endopeptidases - genetics Endopeptidases - metabolism Escherichia coli Haemophilus influenzae Haemophilus influenzae - enzymology Haemophilus influenzae - genetics Hydrogen bonds Imidazoles Lipid bilayers Lipid Metabolism Lipids Medical research Membranes Models, Molecular Molecules Peptides Protein Binding Protein Structure, Tertiary Proteomics Structural Homology, Protein
Online-Zugang:	Volltext
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