Computer-aided design of modular protein devices: Boolean AND gene activation

Many potentially useful synthetic gene networks require the expression of an engineered gene if and only if two different DNA-binding proteins exist in sufficient concentration. While some natural and engineered systems activate gene expression according to a logical AND-like behavior, they often ut...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Physical biology 2006-12, Vol.3 (4), p.295-310
Hauptverfasser:	Salis, H, Kaznessis, Y N
Format:	Artikel
Sprache:	eng
Schlagworte:	Computer Simulation Computer-Aided Design DNA-Binding Proteins - metabolism Gene Expression Regulation Gene Regulatory Networks Mathematics Models, Genetic Models, Statistical Nonlinear Dynamics Nuclear Matrix-Associated Proteins - metabolism Stochastic Processes Trans-Activators - metabolism Transcriptional Activation Zinc Fingers
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!