Anatomic Variations in the Circle of Willis in Patients with Symptomatic Carotid Artery Stenosis Assessed with Multidetector Row CT Angiography
Purpose: To assess the presence of anterior and posterior collateral pathways in the circle of Willis in patients with symptomatic carotid artery stenosis (SCAS) and to compare this to patients without carotid artery stenosis. Materials and Methods: Multislice CT angiography was performed in 91 pati...
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| Veröffentlicht in: | Cerebrovascular diseases (Basel, Switzerland) Switzerland), 2007-03, Vol.23 (4), p.267-274 |
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| creator | Waaijer, A. van Leeuwen, M.S. van der Worp, H.B. Verhagen, H.J.M. Mali, W.P.T.M. Velthuis, B.K. |
| description | Purpose: To assess the presence of anterior and posterior collateral pathways in the circle of Willis in patients with symptomatic carotid artery stenosis (SCAS) and to compare this to patients without carotid artery stenosis. Materials and Methods: Multislice CT angiography was performed in 91 patients and 91 control subjects. Using consensus reading, 2 observers evaluated the presence and diameter of the anterior communicating artery (AcomA), the A1 segments of the anterior cerebral arteries, the posterior communicating arteries (PcomA) and the P1 segments of the posterior cerebral arteries. Anterior or posterior pathways were assumed to be present if the diameter of continuous arterial segments was >1 mm; both A1 segments and AcomA anterior, and ipsilateral P1 segment and PcomA posterior. Comparison between patients and controls was performed using the χ 2 test. Results: In the patients we found significantly more hypoplastic ( |
| doi_str_mv | 10.1159/000098326 |
| format | Article |
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Materials and Methods: Multislice CT angiography was performed in 91 patients and 91 control subjects. Using consensus reading, 2 observers evaluated the presence and diameter of the anterior communicating artery (AcomA), the A1 segments of the anterior cerebral arteries, the posterior communicating arteries (PcomA) and the P1 segments of the posterior cerebral arteries. Anterior or posterior pathways were assumed to be present if the diameter of continuous arterial segments was >1 mm; both A1 segments and AcomA anterior, and ipsilateral P1 segment and PcomA posterior. Comparison between patients and controls was performed using the χ 2 test. Results: In the patients we found significantly more hypoplastic (<1 mm) or invisible A1 segments (16 and 14 vs. 4 and 1, respectively, p < 0.01). The AcomA was invisible in 4 patients versus 1 control. An isolated compromised anterior pathway and a combined compromised anterior and posterior pathway occurred more frequently in the patients as compared to the controls; 9 versus 1% (p < 0.01) and 26 versus 4% (p < 0.01). Conclusion: A compromised anterior collateral pathway, usually combined with a compromised posterior pathway, occurs more frequently in patients with SCAS as compared to controls, which suggests a relation between symptomatic carotid stenosis and an incomplete circle of Willis.</description><identifier>ISSN: 1015-9770</identifier><identifier>EISSN: 1421-9786</identifier><identifier>DOI: 10.1159/000098326</identifier><identifier>PMID: 17199084</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carotid Stenosis - diagnostic imaging ; Carotid Stenosis - physiopathology ; Cerebral Angiography - methods ; Cerebral Arteries - diagnostic imaging ; Cerebrovascular Circulation ; Circle of Willis - abnormalities ; Circle of Willis - diagnostic imaging ; Circle of Willis - physiopathology ; Collateral Circulation ; Female ; Humans ; Male ; Middle Aged ; Original Paper ; Prospective Studies ; Tomography, X-Ray Computed - methods</subject><ispartof>Cerebrovascular diseases (Basel, Switzerland), 2007-03, Vol.23 (4), p.267-274</ispartof><rights>2007 S. Karger AG, Basel</rights><rights>(c) 2007 S. Karger AG, Basel.</rights><rights>Copyright (c) 2007 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c330t-421d5afc8fdcb1f7604c0bd1576643e5ef5c003eb3694eb9077c0f37e3873f0c3</citedby><cites>FETCH-LOGICAL-c330t-421d5afc8fdcb1f7604c0bd1576643e5ef5c003eb3694eb9077c0f37e3873f0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17199084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Waaijer, A.</creatorcontrib><creatorcontrib>van Leeuwen, M.S.</creatorcontrib><creatorcontrib>van der Worp, H.B.</creatorcontrib><creatorcontrib>Verhagen, H.J.M.</creatorcontrib><creatorcontrib>Mali, W.P.T.M.</creatorcontrib><creatorcontrib>Velthuis, B.K.</creatorcontrib><title>Anatomic Variations in the Circle of Willis in Patients with Symptomatic Carotid Artery Stenosis Assessed with Multidetector Row CT Angiography</title><title>Cerebrovascular diseases (Basel, Switzerland)</title><addtitle>Cerebrovasc Dis</addtitle><description>Purpose: To assess the presence of anterior and posterior collateral pathways in the circle of Willis in patients with symptomatic carotid artery stenosis (SCAS) and to compare this to patients without carotid artery stenosis. Materials and Methods: Multislice CT angiography was performed in 91 patients and 91 control subjects. Using consensus reading, 2 observers evaluated the presence and diameter of the anterior communicating artery (AcomA), the A1 segments of the anterior cerebral arteries, the posterior communicating arteries (PcomA) and the P1 segments of the posterior cerebral arteries. Anterior or posterior pathways were assumed to be present if the diameter of continuous arterial segments was >1 mm; both A1 segments and AcomA anterior, and ipsilateral P1 segment and PcomA posterior. Comparison between patients and controls was performed using the χ 2 test. Results: In the patients we found significantly more hypoplastic (<1 mm) or invisible A1 segments (16 and 14 vs. 4 and 1, respectively, p < 0.01). The AcomA was invisible in 4 patients versus 1 control. An isolated compromised anterior pathway and a combined compromised anterior and posterior pathway occurred more frequently in the patients as compared to the controls; 9 versus 1% (p < 0.01) and 26 versus 4% (p < 0.01). Conclusion: A compromised anterior collateral pathway, usually combined with a compromised posterior pathway, occurs more frequently in patients with SCAS as compared to controls, which suggests a relation between symptomatic carotid stenosis and an incomplete circle of Willis.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carotid Stenosis - diagnostic imaging</subject><subject>Carotid Stenosis - physiopathology</subject><subject>Cerebral Angiography - methods</subject><subject>Cerebral Arteries - diagnostic imaging</subject><subject>Cerebrovascular Circulation</subject><subject>Circle of Willis - abnormalities</subject><subject>Circle of Willis - diagnostic imaging</subject><subject>Circle of Willis - physiopathology</subject><subject>Collateral Circulation</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Prospective Studies</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>1015-9770</issn><issn>1421-9786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0c9r2zAUB3BRWpr-2GHnQhE7DHbIJlm2ZR2N2bpCSsvabkcjy0-JMttKJZmQv2L_ctU6dFAh0EN8vg-Jh9BHSr5SmolvJC5RsCQ_QCc0Tehc8CI_jDWhWaw5maFT79dR5bSgx2hGORWCFOkJ-lcOMtjeKPxbOiODsYPHZsBhBbgyTnWArcZ_TNeZ1_u7SGAIHm9NWOH7Xb-J6XincCWdDabFpQvgdvg-wGB9DJXeQ9ztlLgZu4gggArW4V92i6sHXA5LY5dObla7c3SkZefhw_48Q48_vj9UP-eL26vrqlzMFWMkzOMn20xqVehWNVTznKSKNC3NeJ6nDDLQmSKEQcNykUIjCOeKaMaBFZxpotgZ-jz13Tj7NIIPdW-8gq6TA9jR1wklacGEiPDTO7i2oxvi2-okoUlSsIxF9GVCylnvHeh640wv3a6mpH4ZUf02omgv9w3Hpof2v9zPJIKLCfyVbgnuDUzxZ55qldI</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>Waaijer, A.</creator><creator>van Leeuwen, M.S.</creator><creator>van der Worp, H.B.</creator><creator>Verhagen, H.J.M.</creator><creator>Mali, W.P.T.M.</creator><creator>Velthuis, B.K.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>200703</creationdate><title>Anatomic Variations in the Circle of Willis in Patients with Symptomatic Carotid Artery Stenosis Assessed with Multidetector Row CT Angiography</title><author>Waaijer, A. ; van Leeuwen, M.S. ; van der Worp, H.B. ; Verhagen, H.J.M. ; Mali, W.P.T.M. ; Velthuis, B.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-421d5afc8fdcb1f7604c0bd1576643e5ef5c003eb3694eb9077c0f37e3873f0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carotid Stenosis - diagnostic imaging</topic><topic>Carotid Stenosis - physiopathology</topic><topic>Cerebral Angiography - methods</topic><topic>Cerebral Arteries - diagnostic imaging</topic><topic>Cerebrovascular Circulation</topic><topic>Circle of Willis - abnormalities</topic><topic>Circle of Willis - diagnostic imaging</topic><topic>Circle of Willis - physiopathology</topic><topic>Collateral Circulation</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Prospective Studies</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Waaijer, A.</creatorcontrib><creatorcontrib>van Leeuwen, M.S.</creatorcontrib><creatorcontrib>van der Worp, H.B.</creatorcontrib><creatorcontrib>Verhagen, H.J.M.</creatorcontrib><creatorcontrib>Mali, W.P.T.M.</creatorcontrib><creatorcontrib>Velthuis, B.K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Cerebrovascular diseases (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Waaijer, A.</au><au>van Leeuwen, M.S.</au><au>van der Worp, H.B.</au><au>Verhagen, H.J.M.</au><au>Mali, W.P.T.M.</au><au>Velthuis, B.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anatomic Variations in the Circle of Willis in Patients with Symptomatic Carotid Artery Stenosis Assessed with Multidetector Row CT Angiography</atitle><jtitle>Cerebrovascular diseases (Basel, Switzerland)</jtitle><addtitle>Cerebrovasc Dis</addtitle><date>2007-03</date><risdate>2007</risdate><volume>23</volume><issue>4</issue><spage>267</spage><epage>274</epage><pages>267-274</pages><issn>1015-9770</issn><eissn>1421-9786</eissn><abstract>Purpose: To assess the presence of anterior and posterior collateral pathways in the circle of Willis in patients with symptomatic carotid artery stenosis (SCAS) and to compare this to patients without carotid artery stenosis. Materials and Methods: Multislice CT angiography was performed in 91 patients and 91 control subjects. Using consensus reading, 2 observers evaluated the presence and diameter of the anterior communicating artery (AcomA), the A1 segments of the anterior cerebral arteries, the posterior communicating arteries (PcomA) and the P1 segments of the posterior cerebral arteries. Anterior or posterior pathways were assumed to be present if the diameter of continuous arterial segments was >1 mm; both A1 segments and AcomA anterior, and ipsilateral P1 segment and PcomA posterior. Comparison between patients and controls was performed using the χ 2 test. Results: In the patients we found significantly more hypoplastic (<1 mm) or invisible A1 segments (16 and 14 vs. 4 and 1, respectively, p < 0.01). The AcomA was invisible in 4 patients versus 1 control. An isolated compromised anterior pathway and a combined compromised anterior and posterior pathway occurred more frequently in the patients as compared to the controls; 9 versus 1% (p < 0.01) and 26 versus 4% (p < 0.01). Conclusion: A compromised anterior collateral pathway, usually combined with a compromised posterior pathway, occurs more frequently in patients with SCAS as compared to controls, which suggests a relation between symptomatic carotid stenosis and an incomplete circle of Willis.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>17199084</pmid><doi>10.1159/000098326</doi><tpages>8</tpages></addata></record> |
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| ispartof | Cerebrovascular diseases (Basel, Switzerland), 2007-03, Vol.23 (4), p.267-274 |
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| source | Karger Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Carotid Stenosis - diagnostic imaging Carotid Stenosis - physiopathology Cerebral Angiography - methods Cerebral Arteries - diagnostic imaging Cerebrovascular Circulation Circle of Willis - abnormalities Circle of Willis - diagnostic imaging Circle of Willis - physiopathology Collateral Circulation Female Humans Male Middle Aged Original Paper Prospective Studies Tomography, X-Ray Computed - methods |
| title | Anatomic Variations in the Circle of Willis in Patients with Symptomatic Carotid Artery Stenosis Assessed with Multidetector Row CT Angiography |
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