The effects of Gingko biloba, vitamin E and melatonin on bacterial translocation in thioacetamide-induced fulminant hepatic failure in rats
Bacterial translocation (BT) has been implicated in the development of infectious complications in many serious clinical conditions such as fulminant hepatic failure (FHF). We aimed to investigate the effects of Gingko biloba (GB), vitamin E (Vit E) and melatonin on intestinal oxidative damage and B...
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| Veröffentlicht in: | Acta gastro-enterologica belgica 2006-07, Vol.69 (3), p.268-275 |
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| creator | HARPUTLUOGLU, M. M. M DEMIREL, U KARINCAOGLU, M HILMIOGLU, F KARADAG, N TEMEL, I BAYRAKTAR, M FIRAT, S KARAHAN, D ALADAG, M ALAN, H ATES, F |
| description | Bacterial translocation (BT) has been implicated in the development of infectious complications in many serious clinical conditions such as fulminant hepatic failure (FHF). We aimed to investigate the effects of Gingko biloba (GB), vitamin E (Vit E) and melatonin on intestinal oxidative damage and BT in thioacetamide (TAA)-induced FHF in rats.
A total of 42 rats were divided into five groups. Group 1 (n = 8) was the control group. Group 2 (n = 10) was the TAA group, in which rats received 350 mg/kg TAA daily by the intraperitoneal (ip) route for 3 days. Oral 100 mg/kg GB per day was administered to group 3 (n = 8), oral 200 mg/kg Vit E per day to group 4 (n = 8) and ip 3 mg/kg melatonin per day to group 5 (n = 8) 48 h prior to the first TAA injection and was continued for 5 consecutive days.
When compared with the control group, serious hepatic and intestinal oxidative damage, increased Escherichia coli counts in ileal aspirates and high BT frequencies were observed in the TAA group (all p < 0.0001). Only GB treatment attenuated hepatic oxidative damage (p < 0.0001). There was no difference in intestinal oxidative damage, E. coli counts in ileal aspirates and BT frequency between TAA and the other antioxidant treatment groups (p > 0.05).
Our results suggest that intestinal oxidative damage plays a major role in the development of BT by disrupting the barrier function of intestinal mucosa. |
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A total of 42 rats were divided into five groups. Group 1 (n = 8) was the control group. Group 2 (n = 10) was the TAA group, in which rats received 350 mg/kg TAA daily by the intraperitoneal (ip) route for 3 days. Oral 100 mg/kg GB per day was administered to group 3 (n = 8), oral 200 mg/kg Vit E per day to group 4 (n = 8) and ip 3 mg/kg melatonin per day to group 5 (n = 8) 48 h prior to the first TAA injection and was continued for 5 consecutive days.
When compared with the control group, serious hepatic and intestinal oxidative damage, increased Escherichia coli counts in ileal aspirates and high BT frequencies were observed in the TAA group (all p < 0.0001). Only GB treatment attenuated hepatic oxidative damage (p < 0.0001). There was no difference in intestinal oxidative damage, E. coli counts in ileal aspirates and BT frequency between TAA and the other antioxidant treatment groups (p > 0.05).
Our results suggest that intestinal oxidative damage plays a major role in the development of BT by disrupting the barrier function of intestinal mucosa.</description><identifier>ISSN: 1784-3227</identifier><identifier>PMID: 17168122</identifier><language>eng</language><publisher>Brussels: Société Royale Belge de Gastro-Entérologie</publisher><subject>Analysis of Variance ; Animals ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Bacterial Translocation - drug effects ; Biological and medical sciences ; Biomarkers - blood ; Disease Models, Animal ; Escherichia coli - physiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Ginkgo biloba ; Intestines - drug effects ; Intestines - metabolism ; Intestines - microbiology ; Intestines - physiopathology ; Lipid Peroxidation - drug effects ; Liver Failure, Acute - chemically induced ; Liver Failure, Acute - drug therapy ; Liver Failure, Acute - metabolism ; Liver Failure, Acute - microbiology ; Liver Failure, Acute - mortality ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Lymph Nodes - microbiology ; Male ; Medical sciences ; Melatonin - pharmacology ; Melatonin - therapeutic use ; Mesentery ; Other diseases. Semiology ; Oxidative Stress - drug effects ; Phytotherapy ; Plant Preparations - pharmacology ; Rats ; Spleen - microbiology ; Survival Rate ; Thioacetamide - adverse effects ; Thiobarbituric Acid Reactive Substances - metabolism ; Vitamin E - pharmacology ; Vitamin E - therapeutic use</subject><ispartof>Acta gastro-enterologica belgica, 2006-07, Vol.69 (3), p.268-275</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18288515$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17168122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARPUTLUOGLU, M. M. M</creatorcontrib><creatorcontrib>DEMIREL, U</creatorcontrib><creatorcontrib>KARINCAOGLU, M</creatorcontrib><creatorcontrib>HILMIOGLU, F</creatorcontrib><creatorcontrib>KARADAG, N</creatorcontrib><creatorcontrib>TEMEL, I</creatorcontrib><creatorcontrib>BAYRAKTAR, M</creatorcontrib><creatorcontrib>FIRAT, S</creatorcontrib><creatorcontrib>KARAHAN, D</creatorcontrib><creatorcontrib>ALADAG, M</creatorcontrib><creatorcontrib>ALAN, H</creatorcontrib><creatorcontrib>ATES, F</creatorcontrib><title>The effects of Gingko biloba, vitamin E and melatonin on bacterial translocation in thioacetamide-induced fulminant hepatic failure in rats</title><title>Acta gastro-enterologica belgica</title><addtitle>Acta Gastroenterol Belg</addtitle><description>Bacterial translocation (BT) has been implicated in the development of infectious complications in many serious clinical conditions such as fulminant hepatic failure (FHF). We aimed to investigate the effects of Gingko biloba (GB), vitamin E (Vit E) and melatonin on intestinal oxidative damage and BT in thioacetamide (TAA)-induced FHF in rats.
A total of 42 rats were divided into five groups. Group 1 (n = 8) was the control group. Group 2 (n = 10) was the TAA group, in which rats received 350 mg/kg TAA daily by the intraperitoneal (ip) route for 3 days. Oral 100 mg/kg GB per day was administered to group 3 (n = 8), oral 200 mg/kg Vit E per day to group 4 (n = 8) and ip 3 mg/kg melatonin per day to group 5 (n = 8) 48 h prior to the first TAA injection and was continued for 5 consecutive days.
When compared with the control group, serious hepatic and intestinal oxidative damage, increased Escherichia coli counts in ileal aspirates and high BT frequencies were observed in the TAA group (all p < 0.0001). Only GB treatment attenuated hepatic oxidative damage (p < 0.0001). There was no difference in intestinal oxidative damage, E. coli counts in ileal aspirates and BT frequency between TAA and the other antioxidant treatment groups (p > 0.05).
Our results suggest that intestinal oxidative damage plays a major role in the development of BT by disrupting the barrier function of intestinal mucosa.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Bacterial Translocation - drug effects</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Disease Models, Animal</subject><subject>Escherichia coli - physiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Ginkgo biloba</subject><subject>Intestines - drug effects</subject><subject>Intestines - metabolism</subject><subject>Intestines - microbiology</subject><subject>Intestines - physiopathology</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver Failure, Acute - chemically induced</subject><subject>Liver Failure, Acute - drug therapy</subject><subject>Liver Failure, Acute - metabolism</subject><subject>Liver Failure, Acute - microbiology</subject><subject>Liver Failure, Acute - mortality</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Lymph Nodes - microbiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melatonin - pharmacology</subject><subject>Melatonin - therapeutic use</subject><subject>Mesentery</subject><subject>Other diseases. Semiology</subject><subject>Oxidative Stress - drug effects</subject><subject>Phytotherapy</subject><subject>Plant Preparations - pharmacology</subject><subject>Rats</subject><subject>Spleen - microbiology</subject><subject>Survival Rate</subject><subject>Thioacetamide - adverse effects</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Vitamin E - pharmacology</subject><subject>Vitamin E - therapeutic use</subject><issn>1784-3227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9KAzEQxveg2FL7CpKLNxc22W7-HKXUKhS81HOZTSY2ms0um6zgM_jSptjiXIZv5vd9MHNVzKmQq7JmTMyKZYwfVS61ohWrbooZFZRLyti8-NkfkaC1qFMkvSVbF94_e9I637fwQL5cgs4FsiEQDOnQQ-pD1n0gLeiEowNP0ggh-l5Dcnmet-noetB4shosXTCTRkPs5HMUhESOOGRWEwvOTyOeLCOkeFtcW_ARl-e-KN6eNvv1c7l73b6sH3flQLlKpTZMKWWUVIZWWklOWdUoLoxQwmrODKt5bUHJVlMAITRgFpyjFIi0aepFcfeXO0xth-YwjK6D8ftw-UoG7s8ARA3e5vu0i_-cZFI2tKl_AfF2bS4</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>HARPUTLUOGLU, M. M. M</creator><creator>DEMIREL, U</creator><creator>KARINCAOGLU, M</creator><creator>HILMIOGLU, F</creator><creator>KARADAG, N</creator><creator>TEMEL, I</creator><creator>BAYRAKTAR, M</creator><creator>FIRAT, S</creator><creator>KARAHAN, D</creator><creator>ALADAG, M</creator><creator>ALAN, H</creator><creator>ATES, F</creator><general>Société Royale Belge de Gastro-Entérologie</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20060701</creationdate><title>The effects of Gingko biloba, vitamin E and melatonin on bacterial translocation in thioacetamide-induced fulminant hepatic failure in rats</title><author>HARPUTLUOGLU, M. M. M ; DEMIREL, U ; KARINCAOGLU, M ; HILMIOGLU, F ; KARADAG, N ; TEMEL, I ; BAYRAKTAR, M ; FIRAT, S ; KARAHAN, D ; ALADAG, M ; ALAN, H ; ATES, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p169t-cd2999d989d10c9861205967d797fc62d2363fa98bc1aa77caea9866e87ee1553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Bacterial Translocation - drug effects</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Disease Models, Animal</topic><topic>Escherichia coli - physiology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Ginkgo biloba</topic><topic>Intestines - drug effects</topic><topic>Intestines - metabolism</topic><topic>Intestines - microbiology</topic><topic>Intestines - physiopathology</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Liver Failure, Acute - chemically induced</topic><topic>Liver Failure, Acute - drug therapy</topic><topic>Liver Failure, Acute - metabolism</topic><topic>Liver Failure, Acute - microbiology</topic><topic>Liver Failure, Acute - mortality</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Lymph Nodes - microbiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melatonin - pharmacology</topic><topic>Melatonin - therapeutic use</topic><topic>Mesentery</topic><topic>Other diseases. Semiology</topic><topic>Oxidative Stress - drug effects</topic><topic>Phytotherapy</topic><topic>Plant Preparations - pharmacology</topic><topic>Rats</topic><topic>Spleen - microbiology</topic><topic>Survival Rate</topic><topic>Thioacetamide - adverse effects</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Vitamin E - pharmacology</topic><topic>Vitamin E - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HARPUTLUOGLU, M. M. M</creatorcontrib><creatorcontrib>DEMIREL, U</creatorcontrib><creatorcontrib>KARINCAOGLU, M</creatorcontrib><creatorcontrib>HILMIOGLU, F</creatorcontrib><creatorcontrib>KARADAG, N</creatorcontrib><creatorcontrib>TEMEL, I</creatorcontrib><creatorcontrib>BAYRAKTAR, M</creatorcontrib><creatorcontrib>FIRAT, S</creatorcontrib><creatorcontrib>KARAHAN, D</creatorcontrib><creatorcontrib>ALADAG, M</creatorcontrib><creatorcontrib>ALAN, H</creatorcontrib><creatorcontrib>ATES, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Acta gastro-enterologica belgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HARPUTLUOGLU, M. M. M</au><au>DEMIREL, U</au><au>KARINCAOGLU, M</au><au>HILMIOGLU, F</au><au>KARADAG, N</au><au>TEMEL, I</au><au>BAYRAKTAR, M</au><au>FIRAT, S</au><au>KARAHAN, D</au><au>ALADAG, M</au><au>ALAN, H</au><au>ATES, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of Gingko biloba, vitamin E and melatonin on bacterial translocation in thioacetamide-induced fulminant hepatic failure in rats</atitle><jtitle>Acta gastro-enterologica belgica</jtitle><addtitle>Acta Gastroenterol Belg</addtitle><date>2006-07-01</date><risdate>2006</risdate><volume>69</volume><issue>3</issue><spage>268</spage><epage>275</epage><pages>268-275</pages><issn>1784-3227</issn><abstract>Bacterial translocation (BT) has been implicated in the development of infectious complications in many serious clinical conditions such as fulminant hepatic failure (FHF). We aimed to investigate the effects of Gingko biloba (GB), vitamin E (Vit E) and melatonin on intestinal oxidative damage and BT in thioacetamide (TAA)-induced FHF in rats.
A total of 42 rats were divided into five groups. Group 1 (n = 8) was the control group. Group 2 (n = 10) was the TAA group, in which rats received 350 mg/kg TAA daily by the intraperitoneal (ip) route for 3 days. Oral 100 mg/kg GB per day was administered to group 3 (n = 8), oral 200 mg/kg Vit E per day to group 4 (n = 8) and ip 3 mg/kg melatonin per day to group 5 (n = 8) 48 h prior to the first TAA injection and was continued for 5 consecutive days.
When compared with the control group, serious hepatic and intestinal oxidative damage, increased Escherichia coli counts in ileal aspirates and high BT frequencies were observed in the TAA group (all p < 0.0001). Only GB treatment attenuated hepatic oxidative damage (p < 0.0001). There was no difference in intestinal oxidative damage, E. coli counts in ileal aspirates and BT frequency between TAA and the other antioxidant treatment groups (p > 0.05).
Our results suggest that intestinal oxidative damage plays a major role in the development of BT by disrupting the barrier function of intestinal mucosa.</abstract><cop>Brussels</cop><pub>Société Royale Belge de Gastro-Entérologie</pub><pmid>17168122</pmid><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 1784-3227 |
| ispartof | Acta gastro-enterologica belgica, 2006-07, Vol.69 (3), p.268-275 |
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| language | eng |
| recordid | cdi_pubmed_primary_17168122 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Analysis of Variance Animals Antioxidants - pharmacology Antioxidants - therapeutic use Bacterial Translocation - drug effects Biological and medical sciences Biomarkers - blood Disease Models, Animal Escherichia coli - physiology Gastroenterology. Liver. Pancreas. Abdomen Ginkgo biloba Intestines - drug effects Intestines - metabolism Intestines - microbiology Intestines - physiopathology Lipid Peroxidation - drug effects Liver Failure, Acute - chemically induced Liver Failure, Acute - drug therapy Liver Failure, Acute - metabolism Liver Failure, Acute - microbiology Liver Failure, Acute - mortality Liver. Biliary tract. Portal circulation. Exocrine pancreas Lymph Nodes - microbiology Male Medical sciences Melatonin - pharmacology Melatonin - therapeutic use Mesentery Other diseases. Semiology Oxidative Stress - drug effects Phytotherapy Plant Preparations - pharmacology Rats Spleen - microbiology Survival Rate Thioacetamide - adverse effects Thiobarbituric Acid Reactive Substances - metabolism Vitamin E - pharmacology Vitamin E - therapeutic use |
| title | The effects of Gingko biloba, vitamin E and melatonin on bacterial translocation in thioacetamide-induced fulminant hepatic failure in rats |
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