Agonists of peroxisome proliferators-activated receptors (PPAR) alpha, beta/delta or gamma reduce transforming growth factor (TGF)-beta-induced proteoglycans' production in chondrocytes

To investigate the potency of selective agonists of peroxisome proliferators-activated receptors' (PPAR) isotypes (alpha, beta/delta or gamma) to modulate the stimulating effect of transforming growth factor-beta1 (TGF-beta1) on proteoglycans' (PGs) synthesis in chondrocytes. Rat chondrocy...

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Veröffentlicht in:	Osteoarthritis and cartilage 2007-05, Vol.15 (5), p.493
Hauptverfasser:	Poleni, P E, Bianchi, A, Etienne, S, Koufany, M, Sebillaud, S, Netter, P, Terlain, B, Jouzeau, J Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chondrocytes - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Glycosaminoglycans - biosynthesis p38 Mitogen-Activated Protein Kinases - metabolism Peroxisome Proliferator-Activated Receptors - pharmacology Proteoglycans - biosynthesis Rats Smad Proteins - biosynthesis Transforming Growth Factor beta - agonists
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