Results of hormone therapy with aminoglutethimide (Rodazol) in postmenopausal metastatic breast cancer
44 postmenopausal women with progressive soft tissue, osseous and/or pleuropulmonal metastases of breast cancer were treated with aminoglutethimide (Rodazol) and hydrocortisone. 40 of the 41 patients, evaluated for treatment results, were pretreated hormonally and 17 were additionally pretreated che...
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| Veröffentlicht in: | Geburtshilfe und Frauenheilkunde 1991-04, Vol.51 (4), p.276 |
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| container_title | Geburtshilfe und Frauenheilkunde |
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| creator | Schmidt, U M Brockmann, B Geschke, E |
| description | 44 postmenopausal women with progressive soft tissue, osseous and/or pleuropulmonal metastases of breast cancer were treated with aminoglutethimide (Rodazol) and hydrocortisone. 40 of the 41 patients, evaluated for treatment results, were pretreated hormonally and 17 were additionally pretreated chemotherapeutically. Objective remissions were achieved in 8 of the total of 41 patients (20%) and in 7 of the women (35%), who had previously responded to tamoxifen. Pain reduction was achieved in 4 of 17 cases (23%) with skeletal pain as the main symptom. The response rate was lower than expected. Primary hormonal therapy with Rodazol cannot be recommended in the osseous type of metastatic spread. |
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Objective remissions were achieved in 8 of the total of 41 patients (20%) and in 7 of the women (35%), who had previously responded to tamoxifen. Pain reduction was achieved in 4 of 17 cases (23%) with skeletal pain as the main symptom. The response rate was lower than expected. Primary hormonal therapy with Rodazol cannot be recommended in the osseous type of metastatic spread.</description><identifier>ISSN: 0016-5751</identifier><identifier>PMID: 1713564</identifier><language>ger</language><publisher>Germany</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aminoglutethimide - adverse effects ; Aminoglutethimide - therapeutic use ; Breast Neoplasms - drug therapy ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Neoplasm Metastasis ; Neoplasms, Hormone-Dependent - drug therapy ; Palliative Care</subject><ispartof>Geburtshilfe und Frauenheilkunde, 1991-04, Vol.51 (4), p.276</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1713564$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schmidt, U M</creatorcontrib><creatorcontrib>Brockmann, B</creatorcontrib><creatorcontrib>Geschke, E</creatorcontrib><title>Results of hormone therapy with aminoglutethimide (Rodazol) in postmenopausal metastatic breast cancer</title><title>Geburtshilfe und Frauenheilkunde</title><addtitle>Geburtshilfe Frauenheilkd</addtitle><description>44 postmenopausal women with progressive soft tissue, osseous and/or pleuropulmonal metastases of breast cancer were treated with aminoglutethimide (Rodazol) and hydrocortisone. 40 of the 41 patients, evaluated for treatment results, were pretreated hormonally and 17 were additionally pretreated chemotherapeutically. Objective remissions were achieved in 8 of the total of 41 patients (20%) and in 7 of the women (35%), who had previously responded to tamoxifen. Pain reduction was achieved in 4 of 17 cases (23%) with skeletal pain as the main symptom. The response rate was lower than expected. Primary hormonal therapy with Rodazol cannot be recommended in the osseous type of metastatic spread.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aminoglutethimide - adverse effects</subject><subject>Aminoglutethimide - therapeutic use</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasms, Hormone-Dependent - drug therapy</subject><subject>Palliative Care</subject><issn>0016-5751</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj8tqwzAURLVoSdO0n1DQsl0YpOhhe1lCXxAohOzDtXRdq1iWkGRK-vU1NKszcxYDc0XWjHFdqVrxG3Kb8_dSZcv1iqx4zYXSck36A-Z5LJmGng4h-TAhLQMmiGf648pAwbspfI1zwTI47yzSx0Ow8BvGJ-omGkMuHqcQYc4wUo8FcoHiDO0SLpEamAymO3Ldw5jx_sINOb6-HHfv1f7z7WP3vK-iErLi0gqQym6ZYbXpmtr2ysh2oWw16K00whghUSlgoIVoDCJr6rYBg61ZxIY8_M_GufNoTzE5D-l8utwVf2QgUnw</recordid><startdate>199104</startdate><enddate>199104</enddate><creator>Schmidt, U M</creator><creator>Brockmann, B</creator><creator>Geschke, E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>199104</creationdate><title>Results of hormone therapy with aminoglutethimide (Rodazol) in postmenopausal metastatic breast cancer</title><author>Schmidt, U M ; Brockmann, B ; Geschke, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p534-14d3a45d20c07cb87df5c4987d496a624c3cc34e55a0a6338cee08798ace9c633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>ger</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aminoglutethimide - adverse effects</topic><topic>Aminoglutethimide - therapeutic use</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasms, Hormone-Dependent - drug therapy</topic><topic>Palliative Care</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schmidt, U M</creatorcontrib><creatorcontrib>Brockmann, B</creatorcontrib><creatorcontrib>Geschke, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Geburtshilfe und Frauenheilkunde</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schmidt, U M</au><au>Brockmann, B</au><au>Geschke, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Results of hormone therapy with aminoglutethimide (Rodazol) in postmenopausal metastatic breast cancer</atitle><jtitle>Geburtshilfe und Frauenheilkunde</jtitle><addtitle>Geburtshilfe Frauenheilkd</addtitle><date>1991-04</date><risdate>1991</risdate><volume>51</volume><issue>4</issue><spage>276</spage><pages>276-</pages><issn>0016-5751</issn><abstract>44 postmenopausal women with progressive soft tissue, osseous and/or pleuropulmonal metastases of breast cancer were treated with aminoglutethimide (Rodazol) and hydrocortisone. 40 of the 41 patients, evaluated for treatment results, were pretreated hormonally and 17 were additionally pretreated chemotherapeutically. Objective remissions were achieved in 8 of the total of 41 patients (20%) and in 7 of the women (35%), who had previously responded to tamoxifen. Pain reduction was achieved in 4 of 17 cases (23%) with skeletal pain as the main symptom. The response rate was lower than expected. Primary hormonal therapy with Rodazol cannot be recommended in the osseous type of metastatic spread.</abstract><cop>Germany</cop><pmid>1713564</pmid></addata></record> |
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| identifier | ISSN: 0016-5751 |
| ispartof | Geburtshilfe und Frauenheilkunde, 1991-04, Vol.51 (4), p.276 |
| issn | 0016-5751 |
| language | ger |
| recordid | cdi_pubmed_primary_1713564 |
| source | MEDLINE; Thieme Connect Journals |
| subjects | Adult Aged Aged, 80 and over Aminoglutethimide - adverse effects Aminoglutethimide - therapeutic use Breast Neoplasms - drug therapy Female Follow-Up Studies Humans Middle Aged Neoplasm Metastasis Neoplasms, Hormone-Dependent - drug therapy Palliative Care |
| title | Results of hormone therapy with aminoglutethimide (Rodazol) in postmenopausal metastatic breast cancer |
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