Silencing of X-linked Inhibitor of Apoptosis (XIAP) Decreases Gemcitabine Resistance of Pancreatic Cancer Cells

Background: The X-linked inhibitor of apoptosis (XIAP) belongs to a family of proteins that suppresses apoptosis by inhibition of caspases in some cancers. It confers resistance to apoptosis induction by chemotherapeutic agents. The aim of this study was to evaluate the influence of XIAP in pancreat...

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Veröffentlicht in:	Anticancer research 2006-09, Vol.26 (5A), p.3265-3273
Hauptverfasser:	SHRIKHANDE, Shailesh V, KLEEFF, Jorg, KAYED, Hany, KELEG, Shereen, REISER, Carolin, GIESE, Thomas, BUCHLER, Markus W, ESPOSITO, Irene, FRIESS, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antimetabolites, Antineoplastic - therapeutic use Apoptosis Biological and medical sciences Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Case-Control Studies Caspases - metabolism Cell Line, Tumor Cell Proliferation Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Drug Resistance, Neoplasm - genetics Female Gastroenterology. Liver. Pancreas. Abdomen Gene Silencing Humans Immunoblotting Immunoenzyme Techniques Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Pancreas - metabolism Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatitis, Chronic - drug therapy Pancreatitis, Chronic - genetics Pancreatitis, Chronic - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - pharmacology Survival Rate Tumors X-Linked Inhibitor of Apoptosis Protein - antagonists & inhibitors X-Linked Inhibitor of Apoptosis Protein - genetics X-Linked Inhibitor of Apoptosis Protein - metabolism
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