Intracoronary transplantation of autologous bone marrow mesenchymal stem cells for ischemic cardiomyopathy due to isolated chronic occluded left anterior descending artery
Studies have revealed that stem cells improve clinical outcomes in patients with severe ischemic cardiomyopathy, but the role of bone marrow mesenchymal stem cells is not well understood. Twenty-two patients received an implantation of autologous bone marrow mesenchymal stem cell therapy; another 23...
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| Veröffentlicht in: | The Journal of invasive cardiology 2006-11, Vol.18 (11), p.552 |
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| container_title | The Journal of invasive cardiology |
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| creator | Chen, Shaoliang Liu, Zhizhong Tian, Nailiang Zhang, Junjie Yei, Fei Duan, Baoxian Zhu, Zhongsheng Lin, Song Kwan, Tak W |
| description | Studies have revealed that stem cells improve clinical outcomes in patients with severe ischemic cardiomyopathy, but the role of bone marrow mesenchymal stem cells is not well understood.
Twenty-two patients received an implantation of autologous bone marrow mesenchymal stem cell therapy; another 23 patients were placed in a control group after percutaneous coronary intervention (PCI) of the chronically occluded left anterior descending artery.
Reversible defect in the cell therapy group decreased from 16 +/- 8% at baseline to 6 +/- 2% at 12 months (p < 0.05), and this improvement was maintained throughout the entire follow-up period. Compared to the control group (5 +/- 3 METS at baseline vs. 5 +/- 3 METS at 3 months; p = NS), the level of exercise tolerance improved significantly 3 months after cell therapy (5 +/- 2 METS at baseline vs. 7 +/- 3 METS at 3 months; p < 0.05). The NYHA function class also improved in the cell therapy group (2.7 +/- 0.8 at baseline vs. 1.6 +/- 0.1 at 3 months; p < 0.05). PCI alone did not increase left ventricular ejection fraction (LVEF), but following stem cell therapy, the LVEF increased significantly from 26 +/- 6% at baseline to 37 +/- 9% at 3 months (p < 0.05).
Intracoronary transplantation of autologous bone marrow mesenchymal stem cells improved clinical outcomes in patients with chronic ischemic cardiomyopathy. |
| format | Article |
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Twenty-two patients received an implantation of autologous bone marrow mesenchymal stem cell therapy; another 23 patients were placed in a control group after percutaneous coronary intervention (PCI) of the chronically occluded left anterior descending artery.
Reversible defect in the cell therapy group decreased from 16 +/- 8% at baseline to 6 +/- 2% at 12 months (p < 0.05), and this improvement was maintained throughout the entire follow-up period. Compared to the control group (5 +/- 3 METS at baseline vs. 5 +/- 3 METS at 3 months; p = NS), the level of exercise tolerance improved significantly 3 months after cell therapy (5 +/- 2 METS at baseline vs. 7 +/- 3 METS at 3 months; p < 0.05). The NYHA function class also improved in the cell therapy group (2.7 +/- 0.8 at baseline vs. 1.6 +/- 0.1 at 3 months; p < 0.05). PCI alone did not increase left ventricular ejection fraction (LVEF), but following stem cell therapy, the LVEF increased significantly from 26 +/- 6% at baseline to 37 +/- 9% at 3 months (p < 0.05).
Intracoronary transplantation of autologous bone marrow mesenchymal stem cells improved clinical outcomes in patients with chronic ischemic cardiomyopathy.</description><identifier>EISSN: 1557-2501</identifier><identifier>PMID: 17090821</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Angioplasty, Balloon, Coronary - methods ; Bone Marrow Transplantation - methods ; Cardiomyopathies - etiology ; Cardiomyopathies - mortality ; Cardiomyopathies - therapy ; Chronic Disease ; Combined Modality Therapy ; Coronary Angiography ; Coronary Stenosis - complications ; Coronary Stenosis - diagnostic imaging ; Female ; Follow-Up Studies ; Humans ; Injections, Intralesional ; Male ; Mesenchymal Stem Cell Transplantation - methods ; Middle Aged ; Myocardial Ischemia - etiology ; Myocardial Ischemia - mortality ; Myocardial Ischemia - therapy ; Prospective Studies ; Reference Values ; Risk Assessment ; Severity of Illness Index ; Survival Rate ; Transplantation, Autologous ; Treatment Outcome ; Vascular Patency</subject><ispartof>The Journal of invasive cardiology, 2006-11, Vol.18 (11), p.552</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17090821$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Shaoliang</creatorcontrib><creatorcontrib>Liu, Zhizhong</creatorcontrib><creatorcontrib>Tian, Nailiang</creatorcontrib><creatorcontrib>Zhang, Junjie</creatorcontrib><creatorcontrib>Yei, Fei</creatorcontrib><creatorcontrib>Duan, Baoxian</creatorcontrib><creatorcontrib>Zhu, Zhongsheng</creatorcontrib><creatorcontrib>Lin, Song</creatorcontrib><creatorcontrib>Kwan, Tak W</creatorcontrib><title>Intracoronary transplantation of autologous bone marrow mesenchymal stem cells for ischemic cardiomyopathy due to isolated chronic occluded left anterior descending artery</title><title>The Journal of invasive cardiology</title><addtitle>J Invasive Cardiol</addtitle><description>Studies have revealed that stem cells improve clinical outcomes in patients with severe ischemic cardiomyopathy, but the role of bone marrow mesenchymal stem cells is not well understood.
Twenty-two patients received an implantation of autologous bone marrow mesenchymal stem cell therapy; another 23 patients were placed in a control group after percutaneous coronary intervention (PCI) of the chronically occluded left anterior descending artery.
Reversible defect in the cell therapy group decreased from 16 +/- 8% at baseline to 6 +/- 2% at 12 months (p < 0.05), and this improvement was maintained throughout the entire follow-up period. Compared to the control group (5 +/- 3 METS at baseline vs. 5 +/- 3 METS at 3 months; p = NS), the level of exercise tolerance improved significantly 3 months after cell therapy (5 +/- 2 METS at baseline vs. 7 +/- 3 METS at 3 months; p < 0.05). The NYHA function class also improved in the cell therapy group (2.7 +/- 0.8 at baseline vs. 1.6 +/- 0.1 at 3 months; p < 0.05). PCI alone did not increase left ventricular ejection fraction (LVEF), but following stem cell therapy, the LVEF increased significantly from 26 +/- 6% at baseline to 37 +/- 9% at 3 months (p < 0.05).
Intracoronary transplantation of autologous bone marrow mesenchymal stem cells improved clinical outcomes in patients with chronic ischemic cardiomyopathy.</description><subject>Aged</subject><subject>Angioplasty, Balloon, Coronary - methods</subject><subject>Bone Marrow Transplantation - methods</subject><subject>Cardiomyopathies - etiology</subject><subject>Cardiomyopathies - mortality</subject><subject>Cardiomyopathies - therapy</subject><subject>Chronic Disease</subject><subject>Combined Modality Therapy</subject><subject>Coronary Angiography</subject><subject>Coronary Stenosis - complications</subject><subject>Coronary Stenosis - diagnostic imaging</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Injections, Intralesional</subject><subject>Male</subject><subject>Mesenchymal Stem Cell Transplantation - methods</subject><subject>Middle Aged</subject><subject>Myocardial Ischemia - etiology</subject><subject>Myocardial Ischemia - mortality</subject><subject>Myocardial Ischemia - therapy</subject><subject>Prospective Studies</subject><subject>Reference Values</subject><subject>Risk Assessment</subject><subject>Severity of Illness Index</subject><subject>Survival Rate</subject><subject>Transplantation, Autologous</subject><subject>Treatment Outcome</subject><subject>Vascular Patency</subject><issn>1557-2501</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1qwzAQhU2hNGnaK5S5QEA_cWwtS-hPINBN9kGWRrGLrDGSTPGZeskK2q5meO_xPmZuqjWv62YrasZX1X1Kn4wJLhW_q1a8YYq1gq-r72PIURuKFHRcoOwhTV6HrPNAAciBnjN5utKcoKOAMOoY6QtGTBhMv4zaQ8o4gkHvEziKMCTT4zgYMDragcaFJp37BeyMkKnY5HVGC6Yv1BIjY_xsi-DRZShsjEOpsZgMBjuEK-hYtOWhunXaJ3z8m5vq_PpyPrxvTx9vx8PzaTspmbdG2l3jhG2ERWX2zjasVlp21lmnaqxRKNUKydyeY-uUFKLDHW-NxM6IWrRyUz391k5zN6K9THEoNy-X_6fJHwlMbq4</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Chen, Shaoliang</creator><creator>Liu, Zhizhong</creator><creator>Tian, Nailiang</creator><creator>Zhang, Junjie</creator><creator>Yei, Fei</creator><creator>Duan, Baoxian</creator><creator>Zhu, Zhongsheng</creator><creator>Lin, Song</creator><creator>Kwan, Tak W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200611</creationdate><title>Intracoronary transplantation of autologous bone marrow mesenchymal stem cells for ischemic cardiomyopathy due to isolated chronic occluded left anterior descending artery</title><author>Chen, Shaoliang ; Liu, Zhizhong ; Tian, Nailiang ; Zhang, Junjie ; Yei, Fei ; Duan, Baoxian ; Zhu, Zhongsheng ; Lin, Song ; Kwan, Tak W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p93t-c3d47f2d72de9c6fd7059a3bdfdf95e5e2998230f61e8f9322be418c3ebc25283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Angioplasty, Balloon, Coronary - methods</topic><topic>Bone Marrow Transplantation - methods</topic><topic>Cardiomyopathies - etiology</topic><topic>Cardiomyopathies - mortality</topic><topic>Cardiomyopathies - therapy</topic><topic>Chronic Disease</topic><topic>Combined Modality Therapy</topic><topic>Coronary Angiography</topic><topic>Coronary Stenosis - complications</topic><topic>Coronary Stenosis - diagnostic imaging</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Injections, Intralesional</topic><topic>Male</topic><topic>Mesenchymal Stem Cell Transplantation - methods</topic><topic>Middle Aged</topic><topic>Myocardial Ischemia - etiology</topic><topic>Myocardial Ischemia - mortality</topic><topic>Myocardial Ischemia - therapy</topic><topic>Prospective Studies</topic><topic>Reference Values</topic><topic>Risk Assessment</topic><topic>Severity of Illness Index</topic><topic>Survival Rate</topic><topic>Transplantation, Autologous</topic><topic>Treatment Outcome</topic><topic>Vascular Patency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Shaoliang</creatorcontrib><creatorcontrib>Liu, Zhizhong</creatorcontrib><creatorcontrib>Tian, Nailiang</creatorcontrib><creatorcontrib>Zhang, Junjie</creatorcontrib><creatorcontrib>Yei, Fei</creatorcontrib><creatorcontrib>Duan, Baoxian</creatorcontrib><creatorcontrib>Zhu, Zhongsheng</creatorcontrib><creatorcontrib>Lin, Song</creatorcontrib><creatorcontrib>Kwan, Tak W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>The Journal of invasive cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Shaoliang</au><au>Liu, Zhizhong</au><au>Tian, Nailiang</au><au>Zhang, Junjie</au><au>Yei, Fei</au><au>Duan, Baoxian</au><au>Zhu, Zhongsheng</au><au>Lin, Song</au><au>Kwan, Tak W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracoronary transplantation of autologous bone marrow mesenchymal stem cells for ischemic cardiomyopathy due to isolated chronic occluded left anterior descending artery</atitle><jtitle>The Journal of invasive cardiology</jtitle><addtitle>J Invasive Cardiol</addtitle><date>2006-11</date><risdate>2006</risdate><volume>18</volume><issue>11</issue><spage>552</spage><pages>552-</pages><eissn>1557-2501</eissn><abstract>Studies have revealed that stem cells improve clinical outcomes in patients with severe ischemic cardiomyopathy, but the role of bone marrow mesenchymal stem cells is not well understood.
Twenty-two patients received an implantation of autologous bone marrow mesenchymal stem cell therapy; another 23 patients were placed in a control group after percutaneous coronary intervention (PCI) of the chronically occluded left anterior descending artery.
Reversible defect in the cell therapy group decreased from 16 +/- 8% at baseline to 6 +/- 2% at 12 months (p < 0.05), and this improvement was maintained throughout the entire follow-up period. Compared to the control group (5 +/- 3 METS at baseline vs. 5 +/- 3 METS at 3 months; p = NS), the level of exercise tolerance improved significantly 3 months after cell therapy (5 +/- 2 METS at baseline vs. 7 +/- 3 METS at 3 months; p < 0.05). The NYHA function class also improved in the cell therapy group (2.7 +/- 0.8 at baseline vs. 1.6 +/- 0.1 at 3 months; p < 0.05). PCI alone did not increase left ventricular ejection fraction (LVEF), but following stem cell therapy, the LVEF increased significantly from 26 +/- 6% at baseline to 37 +/- 9% at 3 months (p < 0.05).
Intracoronary transplantation of autologous bone marrow mesenchymal stem cells improved clinical outcomes in patients with chronic ischemic cardiomyopathy.</abstract><cop>United States</cop><pmid>17090821</pmid></addata></record> |
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| subjects | Aged Angioplasty, Balloon, Coronary - methods Bone Marrow Transplantation - methods Cardiomyopathies - etiology Cardiomyopathies - mortality Cardiomyopathies - therapy Chronic Disease Combined Modality Therapy Coronary Angiography Coronary Stenosis - complications Coronary Stenosis - diagnostic imaging Female Follow-Up Studies Humans Injections, Intralesional Male Mesenchymal Stem Cell Transplantation - methods Middle Aged Myocardial Ischemia - etiology Myocardial Ischemia - mortality Myocardial Ischemia - therapy Prospective Studies Reference Values Risk Assessment Severity of Illness Index Survival Rate Transplantation, Autologous Treatment Outcome Vascular Patency |
| title | Intracoronary transplantation of autologous bone marrow mesenchymal stem cells for ischemic cardiomyopathy due to isolated chronic occluded left anterior descending artery |
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