Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK

The goal of this study was to identify the mechanisms by which 15-deoxy-Delta(12,14)-prostaglandin J(2) (dPGJ(2)) protects RPE cells from oxidative injury. Cell viability was determined by MTT assay. Protein expression and activation of signaling molecules were detected by Western blot. Reduced glut...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2006-11, Vol.47 (11), p.5098
Hauptverfasser:	Qin, Suofu, McLaughlin, Anne P, De Vries, Gerald W
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Cell Survival Cytoprotection Enzyme Activation Glutathione - metabolism Humans Hydrogen Peroxide - toxicity Immunologic Factors - pharmacology MAP Kinase Kinase 4 - metabolism Mitogen-Activated Protein Kinases - metabolism Oxidative Stress - drug effects p38 Mitogen-Activated Protein Kinases - metabolism Pigment Epithelium of Eye - drug effects Pigment Epithelium of Eye - metabolism PPAR gamma - genetics Prostaglandin D2 - analogs & derivatives Prostaglandin D2 - pharmacology RNA, Messenger - metabolism RNA, Small Interfering - genetics Up-Regulation
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