The anti-amnesic and neuroprotective effects of donepezil against amyloid beta25-35 peptide-induced toxicity in mice involve an interaction with the sigma1 receptor

The acetylcholinesterase inhibitor, donepezil, is also a high affinity sigma(1) receptor agonist. We examined the involvement of sigma(1) receptors in its anti-amnesic and neuroprotective properties against amyloid beta(25-35) peptide-induced toxicity in mice. Mice were given an intracerebroventricu...

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Veröffentlicht in:	British journal of pharmacology 2006-12, Vol.149 (8), p.998
Hauptverfasser:	Meunier, J, Ieni, J, Maurice, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Amnesia - drug therapy Amyloid beta-Peptides - administration & dosage Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - toxicity Animals Avoidance Learning - drug effects Behavior, Animal - drug effects Dose-Response Relationship, Drug Ethylenediamines - pharmacology Fluorescent Dyes Galantamine - pharmacology Indans - administration & dosage Indans - pharmacology Injections, Intraventricular Lipid Peroxidation - drug effects Male Maze Learning - drug effects Mice Neuroprotective Agents Nootropic Agents - administration & dosage Nootropic Agents - pharmacology Peptide Fragments - administration & dosage Peptide Fragments - antagonists & inhibitors Peptide Fragments - toxicity Phenols Phenylcarbamates - pharmacology Piperidines - administration & dosage Piperidines - pharmacology Receptors, sigma - drug effects Rivastigmine Sulfoxides Xylenes
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