Heritable Retroviral Transgenes are Highly Expressed in Chickens

This report describes expression of heritable reticuloendotheliosis virus (REV) vector ME111 in 20 independent lines of transgenic chickens. The results are strikingly different from studies of Moloney virus in transgenic mice, where restricted expression of inherited proviruses has led to their use...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1991-03, Vol.88 (5), p.1736-1740
Hauptverfasser:	Briskin, Michael J., Hsu, Rou-Yin, Boggs, Tina, Schultz, Joseph A., Rishell, William, Bosselman, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Biological and medical sciences Biotechnology Blotting, Northern Chick Embryo Chickens Fundamental and applied biological sciences. Psychology Genes Genetic engineering Genetic technics Genetic Vectors Kanamycin Kinase Liver Liver - enzymology Methods. Procedures. Technologies Nucleic Acid Hybridization Phosphotransferases - genetics Phosphotransferases - metabolism Proviruses Repetitive Sequences, Nucleic Acid Reticuloendotheliosis virus - genetics rev genes RNA RNA - genetics RNA - isolation & purification RNA, Viral - genetics RNA, Viral - isolation & purification Spleen - enzymology Transgenes Transgenic animals Transgenic animals and transgenic plants Tubulin - genetics Viruses
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