Effect of selenium supplementation on activity and mRNA expression of type 1 deiodinase in mice with excessive iodine intake
To investigate the effect of selenium supplementation on the selenium status and selenoenzyme, especially the activity and mRNA expression of type 1 deiodinase (D1) in mice with excessive iodine (EI) intake and to explore the mechanism of selenium intervention on iodine-induced abnormities. Weanling...
Gespeichert in:
| Veröffentlicht in: | Biomedical and environmental sciences 2006-08, Vol.19 (4), p.302 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 4 |
| container_start_page | 302 |
| container_title | Biomedical and environmental sciences |
| container_volume | 19 |
| creator | Yang, Xue-Feng Hou, Xiao-Hui Xu, Jian Guo, Huai-Lan Yinq, Chen-Jiang Chen, Xiao-Yi Sun, Xiu-Fa |
| description | To investigate the effect of selenium supplementation on the selenium status and selenoenzyme, especially the activity and mRNA expression of type 1 deiodinase (D1) in mice with excessive iodine (EI) intake and to explore the mechanism of selenium intervention on iodine-induced abnormities.
Weanling female BALB/c mice were given tap water or 3 mg/L of iodine or supplemented with 0.5 mg/L or 1.0 mg/L of selenium in the presence of excessive iodine for 5 months. Selenium status, thyroid hormone level, hepatic and renal D1 activity and mRNA expression were examined.
Excessive iodine intake significantly decreased the selenium concentration in urine and liver, and the activity of glutathione peroxidase (GSH-Px) in liver. Meanwhile, serum total T4 (TT4) increased while serum total T3 (TT3) decreased. Hepatic D1 enzyme activity and mRNA expression were reduced by 33% and 86%, respectively. Renal D1 enzyme activity and mRNA were reduced by 30% and 55%, respectively. Selenium supplementation obviously increased selenium concentration, activity of GSH-Px and Dl as well as mRNA expression of D1. However, increasing the supplementation of Se from 0.5 to 1.0 mg/L did not further increase selenoenzyme activity and expression.
Relative selenium deficiency caused by excessive iodine plays an essential role in the mechanism of iodine-induced abnormalities. An appropriate dose of selenium supplementation exercises a beneficial intervention. |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_17044649</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17044649</sourcerecordid><originalsourceid>FETCH-LOGICAL-p209t-2fc642725b84a7a9374a36575a3916e017e25eba872fb7e1519fc2b60051e40a3</originalsourceid><addsrcrecordid>eNo1kFtLAzEUhPOg2Fr9C3L-wEKSTTabx1LqBUoF0edydvcEo3sJm7Ra8Mfb9QIDA_MN8zBnbM5Lq7PcluWMXcb4xrkSVpUXbCYMV6pQds6-1s5RnWBwEKml3u87iPsQWuqoT5j80MNJWCd_8OkI2DfQPW2XQJ9hpBh_uIN0DAQCGvJD43uMBL6HztcEHz69nsr11D2c4olPNOE7XbFzh22k6z9fsJfb9fPqPts83j2slpssSG5TJl1dKGmkrkqFBm1uFOaFNhpzKwriwpDUVGFppKsMCS2sq2VVcK4FKY75gt387oZ91VGzC6PvcDzu_m_IvwEgmlnP</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effect of selenium supplementation on activity and mRNA expression of type 1 deiodinase in mice with excessive iodine intake</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Yang, Xue-Feng ; Hou, Xiao-Hui ; Xu, Jian ; Guo, Huai-Lan ; Yinq, Chen-Jiang ; Chen, Xiao-Yi ; Sun, Xiu-Fa</creator><creatorcontrib>Yang, Xue-Feng ; Hou, Xiao-Hui ; Xu, Jian ; Guo, Huai-Lan ; Yinq, Chen-Jiang ; Chen, Xiao-Yi ; Sun, Xiu-Fa</creatorcontrib><description>To investigate the effect of selenium supplementation on the selenium status and selenoenzyme, especially the activity and mRNA expression of type 1 deiodinase (D1) in mice with excessive iodine (EI) intake and to explore the mechanism of selenium intervention on iodine-induced abnormities.
Weanling female BALB/c mice were given tap water or 3 mg/L of iodine or supplemented with 0.5 mg/L or 1.0 mg/L of selenium in the presence of excessive iodine for 5 months. Selenium status, thyroid hormone level, hepatic and renal D1 activity and mRNA expression were examined.
Excessive iodine intake significantly decreased the selenium concentration in urine and liver, and the activity of glutathione peroxidase (GSH-Px) in liver. Meanwhile, serum total T4 (TT4) increased while serum total T3 (TT3) decreased. Hepatic D1 enzyme activity and mRNA expression were reduced by 33% and 86%, respectively. Renal D1 enzyme activity and mRNA were reduced by 30% and 55%, respectively. Selenium supplementation obviously increased selenium concentration, activity of GSH-Px and Dl as well as mRNA expression of D1. However, increasing the supplementation of Se from 0.5 to 1.0 mg/L did not further increase selenoenzyme activity and expression.
Relative selenium deficiency caused by excessive iodine plays an essential role in the mechanism of iodine-induced abnormalities. An appropriate dose of selenium supplementation exercises a beneficial intervention.</description><identifier>ISSN: 0895-3988</identifier><identifier>PMID: 17044649</identifier><language>eng</language><publisher>China</publisher><subject>Animals ; Antioxidants - pharmacology ; Creatinine - metabolism ; Creatinine - urine ; Dietary Supplements ; Female ; Iodide Peroxidase - genetics ; Iodide Peroxidase - metabolism ; Iodine - toxicity ; Iodine - urine ; Kidney - metabolism ; Liver - metabolism ; Mice ; Mice, Inbred BALB C ; RNA, Messenger - metabolism ; Selenium - pharmacology ; Selenium - urine ; Thyroxine - blood ; Triiodothyronine - blood</subject><ispartof>Biomedical and environmental sciences, 2006-08, Vol.19 (4), p.302</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17044649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Xue-Feng</creatorcontrib><creatorcontrib>Hou, Xiao-Hui</creatorcontrib><creatorcontrib>Xu, Jian</creatorcontrib><creatorcontrib>Guo, Huai-Lan</creatorcontrib><creatorcontrib>Yinq, Chen-Jiang</creatorcontrib><creatorcontrib>Chen, Xiao-Yi</creatorcontrib><creatorcontrib>Sun, Xiu-Fa</creatorcontrib><title>Effect of selenium supplementation on activity and mRNA expression of type 1 deiodinase in mice with excessive iodine intake</title><title>Biomedical and environmental sciences</title><addtitle>Biomed Environ Sci</addtitle><description>To investigate the effect of selenium supplementation on the selenium status and selenoenzyme, especially the activity and mRNA expression of type 1 deiodinase (D1) in mice with excessive iodine (EI) intake and to explore the mechanism of selenium intervention on iodine-induced abnormities.
Weanling female BALB/c mice were given tap water or 3 mg/L of iodine or supplemented with 0.5 mg/L or 1.0 mg/L of selenium in the presence of excessive iodine for 5 months. Selenium status, thyroid hormone level, hepatic and renal D1 activity and mRNA expression were examined.
Excessive iodine intake significantly decreased the selenium concentration in urine and liver, and the activity of glutathione peroxidase (GSH-Px) in liver. Meanwhile, serum total T4 (TT4) increased while serum total T3 (TT3) decreased. Hepatic D1 enzyme activity and mRNA expression were reduced by 33% and 86%, respectively. Renal D1 enzyme activity and mRNA were reduced by 30% and 55%, respectively. Selenium supplementation obviously increased selenium concentration, activity of GSH-Px and Dl as well as mRNA expression of D1. However, increasing the supplementation of Se from 0.5 to 1.0 mg/L did not further increase selenoenzyme activity and expression.
Relative selenium deficiency caused by excessive iodine plays an essential role in the mechanism of iodine-induced abnormalities. An appropriate dose of selenium supplementation exercises a beneficial intervention.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Creatinine - metabolism</subject><subject>Creatinine - urine</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>Iodide Peroxidase - genetics</subject><subject>Iodide Peroxidase - metabolism</subject><subject>Iodine - toxicity</subject><subject>Iodine - urine</subject><subject>Kidney - metabolism</subject><subject>Liver - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>RNA, Messenger - metabolism</subject><subject>Selenium - pharmacology</subject><subject>Selenium - urine</subject><subject>Thyroxine - blood</subject><subject>Triiodothyronine - blood</subject><issn>0895-3988</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kFtLAzEUhPOg2Fr9C3L-wEKSTTabx1LqBUoF0edydvcEo3sJm7Ra8Mfb9QIDA_MN8zBnbM5Lq7PcluWMXcb4xrkSVpUXbCYMV6pQds6-1s5RnWBwEKml3u87iPsQWuqoT5j80MNJWCd_8OkI2DfQPW2XQJ9hpBh_uIN0DAQCGvJD43uMBL6HztcEHz69nsr11D2c4olPNOE7XbFzh22k6z9fsJfb9fPqPts83j2slpssSG5TJl1dKGmkrkqFBm1uFOaFNhpzKwriwpDUVGFppKsMCS2sq2VVcK4FKY75gt387oZ91VGzC6PvcDzu_m_IvwEgmlnP</recordid><startdate>200608</startdate><enddate>200608</enddate><creator>Yang, Xue-Feng</creator><creator>Hou, Xiao-Hui</creator><creator>Xu, Jian</creator><creator>Guo, Huai-Lan</creator><creator>Yinq, Chen-Jiang</creator><creator>Chen, Xiao-Yi</creator><creator>Sun, Xiu-Fa</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200608</creationdate><title>Effect of selenium supplementation on activity and mRNA expression of type 1 deiodinase in mice with excessive iodine intake</title><author>Yang, Xue-Feng ; Hou, Xiao-Hui ; Xu, Jian ; Guo, Huai-Lan ; Yinq, Chen-Jiang ; Chen, Xiao-Yi ; Sun, Xiu-Fa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-2fc642725b84a7a9374a36575a3916e017e25eba872fb7e1519fc2b60051e40a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Creatinine - metabolism</topic><topic>Creatinine - urine</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>Iodide Peroxidase - genetics</topic><topic>Iodide Peroxidase - metabolism</topic><topic>Iodine - toxicity</topic><topic>Iodine - urine</topic><topic>Kidney - metabolism</topic><topic>Liver - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>RNA, Messenger - metabolism</topic><topic>Selenium - pharmacology</topic><topic>Selenium - urine</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Xue-Feng</creatorcontrib><creatorcontrib>Hou, Xiao-Hui</creatorcontrib><creatorcontrib>Xu, Jian</creatorcontrib><creatorcontrib>Guo, Huai-Lan</creatorcontrib><creatorcontrib>Yinq, Chen-Jiang</creatorcontrib><creatorcontrib>Chen, Xiao-Yi</creatorcontrib><creatorcontrib>Sun, Xiu-Fa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Biomedical and environmental sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Xue-Feng</au><au>Hou, Xiao-Hui</au><au>Xu, Jian</au><au>Guo, Huai-Lan</au><au>Yinq, Chen-Jiang</au><au>Chen, Xiao-Yi</au><au>Sun, Xiu-Fa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of selenium supplementation on activity and mRNA expression of type 1 deiodinase in mice with excessive iodine intake</atitle><jtitle>Biomedical and environmental sciences</jtitle><addtitle>Biomed Environ Sci</addtitle><date>2006-08</date><risdate>2006</risdate><volume>19</volume><issue>4</issue><spage>302</spage><pages>302-</pages><issn>0895-3988</issn><abstract>To investigate the effect of selenium supplementation on the selenium status and selenoenzyme, especially the activity and mRNA expression of type 1 deiodinase (D1) in mice with excessive iodine (EI) intake and to explore the mechanism of selenium intervention on iodine-induced abnormities.
Weanling female BALB/c mice were given tap water or 3 mg/L of iodine or supplemented with 0.5 mg/L or 1.0 mg/L of selenium in the presence of excessive iodine for 5 months. Selenium status, thyroid hormone level, hepatic and renal D1 activity and mRNA expression were examined.
Excessive iodine intake significantly decreased the selenium concentration in urine and liver, and the activity of glutathione peroxidase (GSH-Px) in liver. Meanwhile, serum total T4 (TT4) increased while serum total T3 (TT3) decreased. Hepatic D1 enzyme activity and mRNA expression were reduced by 33% and 86%, respectively. Renal D1 enzyme activity and mRNA were reduced by 30% and 55%, respectively. Selenium supplementation obviously increased selenium concentration, activity of GSH-Px and Dl as well as mRNA expression of D1. However, increasing the supplementation of Se from 0.5 to 1.0 mg/L did not further increase selenoenzyme activity and expression.
Relative selenium deficiency caused by excessive iodine plays an essential role in the mechanism of iodine-induced abnormalities. An appropriate dose of selenium supplementation exercises a beneficial intervention.</abstract><cop>China</cop><pmid>17044649</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0895-3988 |
| ispartof | Biomedical and environmental sciences, 2006-08, Vol.19 (4), p.302 |
| issn | 0895-3988 |
| language | eng |
| recordid | cdi_pubmed_primary_17044649 |
| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Animals Antioxidants - pharmacology Creatinine - metabolism Creatinine - urine Dietary Supplements Female Iodide Peroxidase - genetics Iodide Peroxidase - metabolism Iodine - toxicity Iodine - urine Kidney - metabolism Liver - metabolism Mice Mice, Inbred BALB C RNA, Messenger - metabolism Selenium - pharmacology Selenium - urine Thyroxine - blood Triiodothyronine - blood |
| title | Effect of selenium supplementation on activity and mRNA expression of type 1 deiodinase in mice with excessive iodine intake |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T15%3A27%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20selenium%20supplementation%20on%20activity%20and%20mRNA%20expression%20of%20type%201%20deiodinase%20in%20mice%20with%20excessive%20iodine%20intake&rft.jtitle=Biomedical%20and%20environmental%20sciences&rft.au=Yang,%20Xue-Feng&rft.date=2006-08&rft.volume=19&rft.issue=4&rft.spage=302&rft.pages=302-&rft.issn=0895-3988&rft_id=info:doi/&rft_dat=%3Cpubmed%3E17044649%3C/pubmed%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/17044649&rfr_iscdi=true |