Novel biopolymers as implant matrix for the delivery of ciprofloxacin: Biocompatibility, degradation, and in vitro antibiotic release

The purpose of this study was to investigate the in vitro–in vivo degradation and tissue compatibility of three novel biopolymers viz. polymerized rosin (PR), glycerol ester of polymerized rosin (GPR) and pentaerythritol ester of polymerized rosin (PPR) and study their potential as implant matrix fo...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2007-01, Vol.96 (1), p.132-144
Hauptverfasser:	Fulzele, Suniket V., Satturwar, Prashant M., Dorle, Avinash K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry biocompatibility biodegradation Biological and medical sciences biopolymers Biopolymers - adverse effects Biopolymers - chemistry Biopolymers - pharmacokinetics Biotransformation Chemistry, Pharmaceutical Ciprofloxacin - chemistry Delayed-Action Preparations Drug Implants drug release Foreign-Body Reaction - chemically induced Foreign-Body Reaction - pathology General pharmacology Glycerides - adverse effects Glycerides - chemistry Glycerides - pharmacokinetics implants Male Materials Testing Medical sciences Microscopy, Electron, Scanning Molecular Weight Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Porosity Propylene Glycols - adverse effects Propylene Glycols - chemistry Propylene Glycols - pharmacokinetics Rats Rats, Wistar Resins, Plant - adverse effects Resins, Plant - chemistry Resins, Plant - pharmacokinetics rosin Solubility Subcutaneous Tissue - pathology Time Factors
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