Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection

Histone deacetylase inhibitors (HDACi) induce growth arrest, apoptosis, and differentiation, particularly in colon cancer cells where they are potential chemopreventive agents. HDACi induction of the cyclin-dependent kinase inhibitor p21(waf1) has been shown to require ataxia-telangiectasia mutated...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2006-09, Vol.131 (3), p.841
Hauptverfasser:	Bai, Longchuan, Kao, John Y, Law, David J, Merchant, Juanita L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia Telangiectasia Mutated Proteins Cell Cycle Proteins - metabolism Cell Line, Tumor Colitis - chemically induced Colitis - metabolism Colitis - pathology Cyclin-Dependent Kinase Inhibitor p21 - genetics Dextran Sulfate - toxicity DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Histone Deacetylases - pharmacology Humans Immunoprecipitation In Vitro Techniques Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Mice Microscopy, Fluorescence Mutation Protein-Serine-Threonine Kinases - metabolism RNA - genetics Transcription Factors - genetics Transcription Factors - metabolism Tumor Suppressor Proteins - metabolism
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