From in vivo to in vitro/in silico ADME: progress and challenges
High-throughput screening technologies in biological sciences of large libraries of compounds obtained via combinatorial or parallel chemistry approaches, as well as the application of design rules for drug-likeness, have resulted in more hits to be evaluated with respect to their ADME or drug metab...
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Veröffentlicht in: | Expert opinion on drug metabolism & toxicology 2005-06, Vol.1 (1), p.1-4 |
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description | High-throughput screening technologies in biological sciences of large libraries of compounds obtained via combinatorial or parallel chemistry approaches, as well as the application of design rules for drug-likeness, have resulted in more hits to be evaluated with respect to their ADME or drug metabolism and pharmacokinetic properties. The traditional in vivo methods using preclinical species, such as rat, dog or monkey, are no longer sufficient to cope with this demand. This editorial discusses the changes towards medium- to high-throughput in vitro and in silico ADME screening. In addition, much more attention is now put on early safety and risk assessment of promising lead series and potential clinical candidates. |
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The traditional in vivo methods using preclinical species, such as rat, dog or monkey, are no longer sufficient to cope with this demand. This editorial discusses the changes towards medium- to high-throughput in vitro and in silico ADME screening. 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In addition, much more attention is now put on early safety and risk assessment of promising lead series and potential clinical candidates.</description><subject>ADME</subject><subject>Animals</subject><subject>DMPK</subject><subject>Drug Design</subject><subject>Drug Evaluation, Preclinical - methods</subject><subject>Drug Evaluation, Preclinical - trends</subject><subject>high-throughput screening</subject><subject>Humans</subject><subject>in combo screening</subject><subject>in silico ADME</subject><subject>lead profiling</subject><subject>Pharmaceutical Preparations - metabolism</subject><subject>Technology, Pharmaceutical - methods</subject><subject>Technology, Pharmaceutical - trends</subject><subject>toxicology</subject><issn>1742-5255</issn><issn>1744-7607</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1PwzAQxS0EoqWwMqJMbGn9lThhoiotIBWxwGzZjtOmcuJiJ0X970lIEWKo0A33dPe7p9MD4BrBMYoQmyBGcYSjaIy6OgHDdkBDFkN2-q1x2G0H4ML7DYQUERKfgwGKU4xjyobgfuFsGRRVsCt2NqhtL2tnJ63whSmUDaYPL_O7YOvsymnvA1FlgVoLY3S10v4SnOXCeH116CPwvpi_zZ7C5evj82y6DBUhSR1iGctcyIygGOaSQqypULmSKMsYpgjLKI1ygSCNMhHRlAqJ0iSGSCYKi0QTMgK3vW_7x0ejfc3LwittjKi0bTxnECWYwvRfEEMSswR3juMeVM5673TOt64ohdtzBHkXLv8Jl6Ou2oObg3MjS5394oc0WyDtgaLKrSvFp3Um47XYG-tyJypVeE6Omid_btdamHqthNN8YxtXtdke--sLQgaYBA</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Van de Waterbeemd, Han</creator><general>Ashley Publications Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>From in vivo to in vitro/in silico ADME: progress and challenges</title><author>Van de Waterbeemd, Han</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-2b6bfabd3160fb402e4acfcb1dd72412b595fa1045da5494ab198601b8c2a8e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>ADME</topic><topic>Animals</topic><topic>DMPK</topic><topic>Drug Design</topic><topic>Drug Evaluation, Preclinical - methods</topic><topic>Drug Evaluation, Preclinical - trends</topic><topic>high-throughput screening</topic><topic>Humans</topic><topic>in combo screening</topic><topic>in silico ADME</topic><topic>lead profiling</topic><topic>Pharmaceutical Preparations - metabolism</topic><topic>Technology, Pharmaceutical - methods</topic><topic>Technology, Pharmaceutical - trends</topic><topic>toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van de Waterbeemd, Han</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Expert opinion on drug metabolism & toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van de Waterbeemd, Han</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>From in vivo to in vitro/in silico ADME: progress and challenges</atitle><jtitle>Expert opinion on drug metabolism & toxicology</jtitle><addtitle>Expert Opin Drug Metab Toxicol</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>1</volume><issue>1</issue><spage>1</spage><epage>4</epage><pages>1-4</pages><issn>1742-5255</issn><eissn>1744-7607</eissn><abstract>High-throughput screening technologies in biological sciences of large libraries of compounds obtained via combinatorial or parallel chemistry approaches, as well as the application of design rules for drug-likeness, have resulted in more hits to be evaluated with respect to their ADME or drug metabolism and pharmacokinetic properties. 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subjects | ADME Animals DMPK Drug Design Drug Evaluation, Preclinical - methods Drug Evaluation, Preclinical - trends high-throughput screening Humans in combo screening in silico ADME lead profiling Pharmaceutical Preparations - metabolism Technology, Pharmaceutical - methods Technology, Pharmaceutical - trends toxicology |
title | From in vivo to in vitro/in silico ADME: progress and challenges |
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