From in vivo to in vitro/in silico ADME: progress and challenges

High-throughput screening technologies in biological sciences of large libraries of compounds obtained via combinatorial or parallel chemistry approaches, as well as the application of design rules for drug-likeness, have resulted in more hits to be evaluated with respect to their ADME or drug metab...

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Veröffentlicht in:Expert opinion on drug metabolism & toxicology 2005-06, Vol.1 (1), p.1-4
1. Verfasser: Van de Waterbeemd, Han
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description High-throughput screening technologies in biological sciences of large libraries of compounds obtained via combinatorial or parallel chemistry approaches, as well as the application of design rules for drug-likeness, have resulted in more hits to be evaluated with respect to their ADME or drug metabolism and pharmacokinetic properties. The traditional in vivo methods using preclinical species, such as rat, dog or monkey, are no longer sufficient to cope with this demand. This editorial discusses the changes towards medium- to high-throughput in vitro and in silico ADME screening. In addition, much more attention is now put on early safety and risk assessment of promising lead series and potential clinical candidates.
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source MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete
subjects ADME
Animals
DMPK
Drug Design
Drug Evaluation, Preclinical - methods
Drug Evaluation, Preclinical - trends
high-throughput screening
Humans
in combo screening
in silico ADME
lead profiling
Pharmaceutical Preparations - metabolism
Technology, Pharmaceutical - methods
Technology, Pharmaceutical - trends
toxicology
title From in vivo to in vitro/in silico ADME: progress and challenges
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