Inhibition of Potassium- and Ischemia-Evoked [3H] D-Aspartate Release from Isolated Bovine Retina by Cannabinoids
We investigated the effect of cannabinoids on potassium chloride (K+)- and ischemia-induced [3H]D-aspartate release from isolated bovine retinae. The superfusion method was employed for studies of [3H]-neurotransmitter release. Cannabinoid receptor CB1 agonists, but not the CB2 agonist JWH 015, inhi...
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| Veröffentlicht in: | Current eye research 2006-01, Vol.31 (7-8), p.645-653 |
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| creator | Opere, Catherine A. Zheng, Wei Dong Zhao, Min Lee, Jin Sook Kulkarni, Kaustubh H. Ohia, Sunny E. |
| description | We investigated the effect of cannabinoids on potassium chloride (K+)- and ischemia-induced [3H]D-aspartate release from isolated bovine retinae. The superfusion method was employed for studies of [3H]-neurotransmitter release. Cannabinoid receptor CB1 agonists, but not the CB2 agonist JWH 015, inhibited K+-induced [3H]D-aspartate release from bovine retinae with the following rank order of activity: anandamide > ACEA > methanandamide > WIN 55,212-2. In the ischemic model, the rank order of activity was as follows: methanandamide > ACEA > WIN 55,212-2. The CB1 receptor antagonist AM 251 blocked inhibitory responses produced by cannabinoids in both experimental conditions. In conclusion, cannabinoids inhibit evoked [3H]D-aspartate release from isolated bovine retinae via an effect on CB1 receptors. |
| doi_str_mv | 10.1080/02713680600762747 |
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The superfusion method was employed for studies of [3H]-neurotransmitter release. Cannabinoid receptor CB1 agonists, but not the CB2 agonist JWH 015, inhibited K+-induced [3H]D-aspartate release from bovine retinae with the following rank order of activity: anandamide > ACEA > methanandamide > WIN 55,212-2. In the ischemic model, the rank order of activity was as follows: methanandamide > ACEA > WIN 55,212-2. The CB1 receptor antagonist AM 251 blocked inhibitory responses produced by cannabinoids in both experimental conditions. In conclusion, cannabinoids inhibit evoked [3H]D-aspartate release from isolated bovine retinae via an effect on CB1 receptors.</description><identifier>ISSN: 0271-3683</identifier><identifier>EISSN: 1460-2202</identifier><identifier>DOI: 10.1080/02713680600762747</identifier><identifier>PMID: 16877273</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; aspartate ; Cannabinoids - pharmacology ; Cattle ; D-Aspartic Acid - antagonists & inhibitors ; D-Aspartic Acid - secretion ; Disease Models, Animal ; excitoxicity neuroprotection and inhibition ; In Vitro Techniques ; ischemia ; Ischemia - drug therapy ; Ischemia - metabolism ; Ischemia - pathology ; Potassium Chloride - pharmacology ; release ; Retina - drug effects ; Retina - metabolism ; Retina - pathology</subject><ispartof>Current eye research, 2006-01, Vol.31 (7-8), p.645-653</ispartof><rights>2006 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-e16bffd06f730bcf30f7bdfc7b51750f56533682852c4eadb72b0df46d6901ff3</citedby><cites>FETCH-LOGICAL-c470t-e16bffd06f730bcf30f7bdfc7b51750f56533682852c4eadb72b0df46d6901ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/02713680600762747$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/02713680600762747$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16877273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Opere, Catherine A.</creatorcontrib><creatorcontrib>Zheng, Wei Dong</creatorcontrib><creatorcontrib>Zhao, Min</creatorcontrib><creatorcontrib>Lee, Jin Sook</creatorcontrib><creatorcontrib>Kulkarni, Kaustubh H.</creatorcontrib><creatorcontrib>Ohia, Sunny E.</creatorcontrib><title>Inhibition of Potassium- and Ischemia-Evoked [3H] D-Aspartate Release from Isolated Bovine Retina by Cannabinoids</title><title>Current eye research</title><addtitle>Curr Eye Res</addtitle><description>We investigated the effect of cannabinoids on potassium chloride (K+)- and ischemia-induced [3H]D-aspartate release from isolated bovine retinae. The superfusion method was employed for studies of [3H]-neurotransmitter release. Cannabinoid receptor CB1 agonists, but not the CB2 agonist JWH 015, inhibited K+-induced [3H]D-aspartate release from bovine retinae with the following rank order of activity: anandamide > ACEA > methanandamide > WIN 55,212-2. In the ischemic model, the rank order of activity was as follows: methanandamide > ACEA > WIN 55,212-2. The CB1 receptor antagonist AM 251 blocked inhibitory responses produced by cannabinoids in both experimental conditions. In conclusion, cannabinoids inhibit evoked [3H]D-aspartate release from isolated bovine retinae via an effect on CB1 receptors.</description><subject>Animals</subject><subject>aspartate</subject><subject>Cannabinoids - pharmacology</subject><subject>Cattle</subject><subject>D-Aspartic Acid - antagonists & inhibitors</subject><subject>D-Aspartic Acid - secretion</subject><subject>Disease Models, Animal</subject><subject>excitoxicity neuroprotection and inhibition</subject><subject>In Vitro Techniques</subject><subject>ischemia</subject><subject>Ischemia - drug therapy</subject><subject>Ischemia - metabolism</subject><subject>Ischemia - pathology</subject><subject>Potassium Chloride - pharmacology</subject><subject>release</subject><subject>Retina - drug effects</subject><subject>Retina - metabolism</subject><subject>Retina - pathology</subject><issn>0271-3683</issn><issn>1460-2202</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9rFDEUxYNY7Lb6AXyRPPk29SaZSaboS7tWu1CoiD6JhPxlU2eSbZKp7Ld3ll2QUujThXN_53DvQegtgTMCPXwAKgjjPXAAwaloxQu0IC2HhlKgL9Fit29mgB2jk1LuAHZC-wodE94LQQVboPtVXAcdakgRJ4-_papKCdPYYBUtXhWzdmNQzdVD-uMs_sWuf-PPzUXZqFxVdfi7G5wqDvucxplOwyxafJkeQtwta4gK6y1eqhiVDjEFW16jI6-G4t4c5in6-eXqx_K6ubn9ulpe3DSmFVAbR7j23gL3goE2noEX2nojdEdEB77jHZtfo31HTeuU1YJqsL7llp8D8Z6dovf73E1O95MrVY6hGDcMKro0Fcl73vddez6DZA-anErJzstNDqPKW0lA7nqWT3qePe8O4ZMenf3vOBQ7A5_2QIg-5VH9TXmwsqrtkLLPKppQJHsu_-Mj-9qpoa6Nyk7epSnHubhnrvsHotyd5g</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Opere, Catherine A.</creator><creator>Zheng, Wei Dong</creator><creator>Zhao, Min</creator><creator>Lee, Jin Sook</creator><creator>Kulkarni, Kaustubh H.</creator><creator>Ohia, Sunny E.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>Inhibition of Potassium- and Ischemia-Evoked [3H] D-Aspartate Release from Isolated Bovine Retina by Cannabinoids</title><author>Opere, Catherine A. ; Zheng, Wei Dong ; Zhao, Min ; Lee, Jin Sook ; Kulkarni, Kaustubh H. ; Ohia, Sunny E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-e16bffd06f730bcf30f7bdfc7b51750f56533682852c4eadb72b0df46d6901ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>aspartate</topic><topic>Cannabinoids - pharmacology</topic><topic>Cattle</topic><topic>D-Aspartic Acid - antagonists & inhibitors</topic><topic>D-Aspartic Acid - secretion</topic><topic>Disease Models, Animal</topic><topic>excitoxicity neuroprotection and inhibition</topic><topic>In Vitro Techniques</topic><topic>ischemia</topic><topic>Ischemia - drug therapy</topic><topic>Ischemia - metabolism</topic><topic>Ischemia - pathology</topic><topic>Potassium Chloride - pharmacology</topic><topic>release</topic><topic>Retina - drug effects</topic><topic>Retina - metabolism</topic><topic>Retina - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Opere, Catherine A.</creatorcontrib><creatorcontrib>Zheng, Wei Dong</creatorcontrib><creatorcontrib>Zhao, Min</creatorcontrib><creatorcontrib>Lee, Jin Sook</creatorcontrib><creatorcontrib>Kulkarni, Kaustubh H.</creatorcontrib><creatorcontrib>Ohia, Sunny E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current eye research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Opere, Catherine A.</au><au>Zheng, Wei Dong</au><au>Zhao, Min</au><au>Lee, Jin Sook</au><au>Kulkarni, Kaustubh H.</au><au>Ohia, Sunny E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Potassium- and Ischemia-Evoked [3H] D-Aspartate Release from Isolated Bovine Retina by Cannabinoids</atitle><jtitle>Current eye research</jtitle><addtitle>Curr Eye Res</addtitle><date>2006-01</date><risdate>2006</risdate><volume>31</volume><issue>7-8</issue><spage>645</spage><epage>653</epage><pages>645-653</pages><issn>0271-3683</issn><eissn>1460-2202</eissn><abstract>We investigated the effect of cannabinoids on potassium chloride (K+)- and ischemia-induced [3H]D-aspartate release from isolated bovine retinae. The superfusion method was employed for studies of [3H]-neurotransmitter release. Cannabinoid receptor CB1 agonists, but not the CB2 agonist JWH 015, inhibited K+-induced [3H]D-aspartate release from bovine retinae with the following rank order of activity: anandamide > ACEA > methanandamide > WIN 55,212-2. In the ischemic model, the rank order of activity was as follows: methanandamide > ACEA > WIN 55,212-2. The CB1 receptor antagonist AM 251 blocked inhibitory responses produced by cannabinoids in both experimental conditions. In conclusion, cannabinoids inhibit evoked [3H]D-aspartate release from isolated bovine retinae via an effect on CB1 receptors.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>16877273</pmid><doi>10.1080/02713680600762747</doi><tpages>9</tpages></addata></record> |
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| ispartof | Current eye research, 2006-01, Vol.31 (7-8), p.645-653 |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals aspartate Cannabinoids - pharmacology Cattle D-Aspartic Acid - antagonists & inhibitors D-Aspartic Acid - secretion Disease Models, Animal excitoxicity neuroprotection and inhibition In Vitro Techniques ischemia Ischemia - drug therapy Ischemia - metabolism Ischemia - pathology Potassium Chloride - pharmacology release Retina - drug effects Retina - metabolism Retina - pathology |
| title | Inhibition of Potassium- and Ischemia-Evoked [3H] D-Aspartate Release from Isolated Bovine Retina by Cannabinoids |
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