Regulation of T Cell Activation and Tolerance by PDL2

T cell activation and tolerance are regulated by costimulatory molecules. Although PD-1 serves as a crucial negative regulator of T cells, the function of its ligands, PDL1 and PDL2, is still controversial. In this study, we created a PDL2-deficient mouse to characterize its function in T cell activ...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-08, Vol.103 (31), p.11695-11700
Hauptverfasser:	Zhang, Yongliang, Chung, Yeonseok, Bishop, Caroline, Daugherty, Betsy, Chute, Hilary, Holst, Paige, Kurahara, Carole, Lott, Fred, Sun, Ning, Welcher, Andrew A., Dong, Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antigen presentation Antigens Antigens, Differentiation - immunology Biological Sciences Cellular biology Chickens Cytokines Exercise tolerance Immune system Immune tolerance Immune Tolerance - physiology Immunization Ligands Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Knockout Molecular biology Molecules Ova Ovalbumin - administration & dosage Ovalbumin - immunology Peptides - genetics Peptides - metabolism Programmed Cell Death 1 Ligand 2 Protein Programmed Cell Death 1 Receptor Rodents T lymphocytes T-Lymphocytes - immunology Transplantation tolerance
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