Inhibition of Ca2+ Influx Is Required for Mitochondrial Reactive Oxygen Species-Induced Endoplasmic Reticulum Ca2+ Depletion and Cell Death in Leukemia Cells

Disturbances of endoplasmic reticulum (ER) Ca 2+ homeostasis or protein processing can lead to ER stress-induced cell death. Increasing evidence suggests that oxidative stress (OS) plays an important role in a variety of cell death mechanisms. To investigate the role of OS in ER stress, we measured...

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Veröffentlicht in:	Molecular pharmacology 2006-10, Vol.70 (4), p.1424
Hauptverfasser:	Zhang, Yicheng, Soboloff, Jonathan, Zhu, Ziping, Berger, Stuart A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Nucleotides - metabolism Antimycin A - pharmacology Antioxidants - pharmacology Atractyloside - pharmacology Calcium - metabolism Caspases - metabolism Cell Death Cell Line, Tumor Dose-Response Relationship, Drug Drug Synergism Econazole - pharmacology Endoplasmic Reticulum - metabolism Humans Leukemia - metabolism Membrane Potentials - drug effects Mitochondria - metabolism Mitochondria - physiology Models, Biological Oxidative Stress Reactive Oxygen Species - metabolism
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