Glycolipid α-C-Galactosylceramide Is a Distinct Inducer of Dendritic Cell Function during Innate and Adaptive Immune Responses of Mice

α-Galactosylceramide (α-GalCer) is the prototype compound for studying the presentation of glycolipids on CD1d molecules to natural killer T (NKT) lymphocytes. A single i.v. dose of glycolipid triggers a cascade of events involving the production of several cytokines over the course of a day, a shor...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-07, Vol.103 (30), p.11252-11257
Hauptverfasser:	Fujii, Shin-ichiro, Shimizu, Kanako, Hemmi, Hiroaki, Fukui, Mikiko, Bonito, Anthony J., Chen, Guangwu, Franck, Richard W., Tsuji, Moriya, Steinman, Ralph M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences CD11c Antigen - biosynthesis Cytokines Cytokines - metabolism Dendritic cells Dendritic Cells - cytology Dendritic Cells - metabolism Galactosylceramides - metabolism Galactosylceramides - physiology Glycolipids Glycolipids - chemistry Glycolipids - metabolism Immune System - physiology Immunity Interferon-gamma - metabolism Interleukin-12 - metabolism Killer Cells, Natural - cytology Melanoma, Experimental - metabolism Mice Mice, Inbred C57BL Molecules Natural killer cells Natural killer T cells Spleen T lymphocytes Tumors Up-Regulation
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