Biochemical and Structural Studies of N5-Carboxyaminoimidazole Ribonucleotide Mutase from the Acidophilic Bacterium Acetobacter aceti

N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) mutase (PurE) catalyzes the reversible interconversion of acid-labile compounds N5-CAIR and 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). We have examined PurE from the acidophilic bacterium Acetobacter aceti (AaPurE), focusing on its adaptation...

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Veröffentlicht in:	Biochemistry (Easton) 2006-07, Vol.45 (27), p.8193-8208
Hauptverfasser:	CONSTANTINE, Charles Z., STARKS, Courtney M., MILL, Christopher P., RANSOME, Aaron E., KARPOWICZ, Steven J., FRANCOIS, Julie A., GOODMAN, Rena A., KAPPOCK, T. Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetobacter - enzymology Amino Acid Sequence Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - chemistry Aminoimidazole Carboxamide - metabolism Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Catalysis Conserved Sequence Crystallography, X-Ray Histidine - chemistry Histidine - genetics Hydrogen-Ion Concentration Intramolecular Transferases - chemistry Intramolecular Transferases - genetics Intramolecular Transferases - metabolism Models, Molecular Mutagenesis Mutation Protein Folding Recombinant Proteins - chemistry Recombinant Proteins - genetics Ribonucleotides - chemistry Ribonucleotides - metabolism
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