Establishment of H2O2-Induced Premature Senescence in Human Fibroblasts Concomitant with Increased Cellular Production of H2O2

: Premature senescence of human fibroblasts is established after exposure to an acute sublethal concentration of H2O2. Overexpression of transforming growth factor‐β1 (TGF‐β1) was shown to be responsible for the appearance of the biomarkers of senescence in these conditions. Other studies have show...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2006-05, Vol.1067 (1), p.210-216
Hauptverfasser:	ZDANOV, STEPHANIE, REMACLE, JOSE, TOUSSAINT, OLIVIER
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Cellular Senescence - drug effects fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Humans hydrogen peroxide Hydrogen Peroxide - analysis Hydrogen Peroxide - metabolism Hydrogen Peroxide - pharmacology Lung - cytology Lung - embryology Models, Biological Oxidants - analysis Oxidants - metabolism Oxidants - pharmacology Oxidative Stress senescence Transforming Growth Factor beta - metabolism Transforming Growth Factor beta1 transforming growth factor-β1 (TGF-β1)
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