Hypoadiponectinemia Is Associated With Progression Toward Type 2 Diabetes and Genetic Variation in the ADIPOQ Gene Promoter

OBJECTIVE:--Adiponectin encoded by the ADIPOQ gene modulates insulin sensitivity and glucose homeostasis. The aim of the current study was to investigate whether ADIPOQ gene variants in the promoter region predict adiponectin levels and type 2 diabetes progression. RESEARCH DESIGN AND METHODS--A tot...

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Veröffentlicht in:	Diabetes care 2006-07, Vol.29 (7), p.1645-1650
Hauptverfasser:	Schwarz, Peter E.H, Towers, Gordon W, Fischer, Sabine, Govindarajalu, Suresh, Schulze, Jan, Bornstein, Stephan R, Hanefeld, Markolf, Vasseur, Francis
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin - blood Adiponectin - genetics Biological and medical sciences Cohort Studies Diabetes Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Disease Progression Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty acids Female Gene Frequency Genetic diversity Genetic Variation Glucose Tolerance Test Haplotypes Humans Male Medical sciences Middle Aged Polymorphism, Single Nucleotide Population Promoter Regions, Genetic - genetics Prospective Studies Risk factors Studies Tests
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