Hypoadiponectinemia Is Associated With Progression Toward Type 2 Diabetes and Genetic Variation in the ADIPOQ Gene Promoter
OBJECTIVE:--Adiponectin encoded by the ADIPOQ gene modulates insulin sensitivity and glucose homeostasis. The aim of the current study was to investigate whether ADIPOQ gene variants in the promoter region predict adiponectin levels and type 2 diabetes progression. RESEARCH DESIGN AND METHODS--A tot...
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| Veröffentlicht in: | Diabetes care 2006-07, Vol.29 (7), p.1645-1650 |
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| creator | Schwarz, Peter E.H Towers, Gordon W Fischer, Sabine Govindarajalu, Suresh Schulze, Jan Bornstein, Stephan R Hanefeld, Markolf Vasseur, Francis |
| description | OBJECTIVE:--Adiponectin encoded by the ADIPOQ gene modulates insulin sensitivity and glucose homeostasis. The aim of the current study was to investigate whether ADIPOQ gene variants in the promoter region predict adiponectin levels and type 2 diabetes progression. RESEARCH DESIGN AND METHODS--A total of 550 subjects with increased risk of type 2 diabetes were investigated; they underwent a 75-g oral glucose tolerance test, repeated after 3 years. Adiponectin levels were analyzed, and two ADIPOQ promoter variant single nucleotide polymorphisms, -11391G>A and -11377C>G, were genotyped. RESULTS:--Tertiles of the adjusted adiponectin levels were associated with single nucleotide polymorphism -11391G>A and -11377C>G haplotypes (P < 0.0001). Carriers of the intermediate/high-level haplotype combination showed a bisected diabetes risk at the 3-year follow-up and were characterized by a "regression" of glucose tolerance. Evolution of disease status correlates with preexisting low adiponectin levels at inclusion rather than with variation in adiponectin levels. CONCLUSIONS:--We present data that gene variants in the ADIPOQ promoter region are associated with variations in adiponectin levels and thus with future type 2 diabetes and disease progression. |
| doi_str_mv | 10.2337/dc05-2123 |
| format | Article |
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The aim of the current study was to investigate whether ADIPOQ gene variants in the promoter region predict adiponectin levels and type 2 diabetes progression. RESEARCH DESIGN AND METHODS--A total of 550 subjects with increased risk of type 2 diabetes were investigated; they underwent a 75-g oral glucose tolerance test, repeated after 3 years. Adiponectin levels were analyzed, and two ADIPOQ promoter variant single nucleotide polymorphisms, -11391G>A and -11377C>G, were genotyped. RESULTS:--Tertiles of the adjusted adiponectin levels were associated with single nucleotide polymorphism -11391G>A and -11377C>G haplotypes (P < 0.0001). Carriers of the intermediate/high-level haplotype combination showed a bisected diabetes risk at the 3-year follow-up and were characterized by a "regression" of glucose tolerance. Evolution of disease status correlates with preexisting low adiponectin levels at inclusion rather than with variation in adiponectin levels. CONCLUSIONS:--We present data that gene variants in the ADIPOQ promoter region are associated with variations in adiponectin levels and thus with future type 2 diabetes and disease progression.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc05-2123</identifier><identifier>PMID: 16801592</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Adiponectin - blood ; Adiponectin - genetics ; Biological and medical sciences ; Cohort Studies ; Diabetes ; Diabetes Mellitus, Type 2 - etiology ; Diabetes Mellitus, Type 2 - genetics ; Diabetes. Impaired glucose tolerance ; Disease Progression ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty acids ; Female ; Gene Frequency ; Genetic diversity ; Genetic Variation ; Glucose Tolerance Test ; Haplotypes ; Humans ; Male ; Medical sciences ; Middle Aged ; Polymorphism, Single Nucleotide ; Population ; Promoter Regions, Genetic - genetics ; Prospective Studies ; Risk factors ; Studies ; Tests</subject><ispartof>Diabetes care, 2006-07, Vol.29 (7), p.1645-1650</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright American Diabetes Association Jul 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3493-b532248c9f54f48a38cebb65d68ada00773141599b46e4712ab349d286a201073</citedby><cites>FETCH-LOGICAL-c3493-b532248c9f54f48a38cebb65d68ada00773141599b46e4712ab349d286a201073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17939900$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16801592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwarz, Peter E.H</creatorcontrib><creatorcontrib>Towers, Gordon W</creatorcontrib><creatorcontrib>Fischer, Sabine</creatorcontrib><creatorcontrib>Govindarajalu, Suresh</creatorcontrib><creatorcontrib>Schulze, Jan</creatorcontrib><creatorcontrib>Bornstein, Stephan R</creatorcontrib><creatorcontrib>Hanefeld, Markolf</creatorcontrib><creatorcontrib>Vasseur, Francis</creatorcontrib><title>Hypoadiponectinemia Is Associated With Progression Toward Type 2 Diabetes and Genetic Variation in the ADIPOQ Gene Promoter</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>OBJECTIVE:--Adiponectin encoded by the ADIPOQ gene modulates insulin sensitivity and glucose homeostasis. The aim of the current study was to investigate whether ADIPOQ gene variants in the promoter region predict adiponectin levels and type 2 diabetes progression. RESEARCH DESIGN AND METHODS--A total of 550 subjects with increased risk of type 2 diabetes were investigated; they underwent a 75-g oral glucose tolerance test, repeated after 3 years. Adiponectin levels were analyzed, and two ADIPOQ promoter variant single nucleotide polymorphisms, -11391G>A and -11377C>G, were genotyped. RESULTS:--Tertiles of the adjusted adiponectin levels were associated with single nucleotide polymorphism -11391G>A and -11377C>G haplotypes (P < 0.0001). Carriers of the intermediate/high-level haplotype combination showed a bisected diabetes risk at the 3-year follow-up and were characterized by a "regression" of glucose tolerance. Evolution of disease status correlates with preexisting low adiponectin levels at inclusion rather than with variation in adiponectin levels. CONCLUSIONS:--We present data that gene variants in the ADIPOQ promoter region are associated with variations in adiponectin levels and thus with future type 2 diabetes and disease progression.</description><subject>Adiponectin - blood</subject><subject>Adiponectin - genetics</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - etiology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Disease Progression</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic diversity</subject><subject>Genetic Variation</subject><subject>Glucose Tolerance Test</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Prospective Studies</subject><subject>Risk factors</subject><subject>Studies</subject><subject>Tests</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0e9r1DAYB_AgijunL_wHNAgOFKr52SYvj21uB4NNvOnL8DRN7zKuTU16jMN_3tQrDHzV0HzyJfk-CL2l5AvjvPraWCILRhl_hhZUc1lIKdRztCBU6EJqzU7Qq5QeCCFCKPUSndBSESo1W6A_14chQOOH0Ds7-t51HvAq4WVKwXoYXYN_-XGL72LYRJeSDz1eh0eIDV4fBocZvvBQu9ElDH2Dr1zvRm_xT4j58IR9j8etw8uL1d3t93_7U1YXRhdfoxct7JJ7M39P0f23y_X5dXFze7U6X94UlgvNi1pyxoSyupWiFQq4sq6uS9mUChogpKo4Ffk1uhalExVlUOdzDVMlMEJJxU_R2TF3iOH33qXRdD5Zt9tB78I-mVLJildcZvjhP_gQ9rHPdzOM8VweZxP6dEQ2hpSia80QfQfxYCgx0zjMNA4zjSPbd3Pgvu5c8yTn_jP4OANIFnZthN769OQqzbUmJLvPR7f1m-2jj840c-3TwkL-wbSpcrCYbvj-iFsIBjYxB97_yFXw3IbiohT8L6o0p-A</recordid><startdate>200607</startdate><enddate>200607</enddate><creator>Schwarz, Peter E.H</creator><creator>Towers, Gordon W</creator><creator>Fischer, Sabine</creator><creator>Govindarajalu, Suresh</creator><creator>Schulze, Jan</creator><creator>Bornstein, Stephan R</creator><creator>Hanefeld, Markolf</creator><creator>Vasseur, Francis</creator><general>American Diabetes Association</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>200607</creationdate><title>Hypoadiponectinemia Is Associated With Progression Toward Type 2 Diabetes and Genetic Variation in the ADIPOQ Gene Promoter</title><author>Schwarz, Peter E.H ; Towers, Gordon W ; Fischer, Sabine ; Govindarajalu, Suresh ; Schulze, Jan ; Bornstein, Stephan R ; Hanefeld, Markolf ; Vasseur, Francis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3493-b532248c9f54f48a38cebb65d68ada00773141599b46e4712ab349d286a201073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adiponectin - blood</topic><topic>Adiponectin - genetics</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - etiology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Disease Progression</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fatty acids</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic diversity</topic><topic>Genetic Variation</topic><topic>Glucose Tolerance Test</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Prospective Studies</topic><topic>Risk factors</topic><topic>Studies</topic><topic>Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schwarz, Peter E.H</creatorcontrib><creatorcontrib>Towers, Gordon W</creatorcontrib><creatorcontrib>Fischer, Sabine</creatorcontrib><creatorcontrib>Govindarajalu, Suresh</creatorcontrib><creatorcontrib>Schulze, Jan</creatorcontrib><creatorcontrib>Bornstein, Stephan R</creatorcontrib><creatorcontrib>Hanefeld, Markolf</creatorcontrib><creatorcontrib>Vasseur, Francis</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schwarz, Peter E.H</au><au>Towers, Gordon W</au><au>Fischer, Sabine</au><au>Govindarajalu, Suresh</au><au>Schulze, Jan</au><au>Bornstein, Stephan R</au><au>Hanefeld, Markolf</au><au>Vasseur, Francis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoadiponectinemia Is Associated With Progression Toward Type 2 Diabetes and Genetic Variation in the ADIPOQ Gene Promoter</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2006-07</date><risdate>2006</risdate><volume>29</volume><issue>7</issue><spage>1645</spage><epage>1650</epage><pages>1645-1650</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>OBJECTIVE:--Adiponectin encoded by the ADIPOQ gene modulates insulin sensitivity and glucose homeostasis. The aim of the current study was to investigate whether ADIPOQ gene variants in the promoter region predict adiponectin levels and type 2 diabetes progression. RESEARCH DESIGN AND METHODS--A total of 550 subjects with increased risk of type 2 diabetes were investigated; they underwent a 75-g oral glucose tolerance test, repeated after 3 years. Adiponectin levels were analyzed, and two ADIPOQ promoter variant single nucleotide polymorphisms, -11391G>A and -11377C>G, were genotyped. RESULTS:--Tertiles of the adjusted adiponectin levels were associated with single nucleotide polymorphism -11391G>A and -11377C>G haplotypes (P < 0.0001). Carriers of the intermediate/high-level haplotype combination showed a bisected diabetes risk at the 3-year follow-up and were characterized by a "regression" of glucose tolerance. Evolution of disease status correlates with preexisting low adiponectin levels at inclusion rather than with variation in adiponectin levels. CONCLUSIONS:--We present data that gene variants in the ADIPOQ promoter region are associated with variations in adiponectin levels and thus with future type 2 diabetes and disease progression.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>16801592</pmid><doi>10.2337/dc05-2123</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adiponectin - blood Adiponectin - genetics Biological and medical sciences Cohort Studies Diabetes Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Disease Progression Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty acids Female Gene Frequency Genetic diversity Genetic Variation Glucose Tolerance Test Haplotypes Humans Male Medical sciences Middle Aged Polymorphism, Single Nucleotide Population Promoter Regions, Genetic - genetics Prospective Studies Risk factors Studies Tests |
| title | Hypoadiponectinemia Is Associated With Progression Toward Type 2 Diabetes and Genetic Variation in the ADIPOQ Gene Promoter |
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