A phase I study of recombinant human interferon-alpha 2a or human lymphoblastoid interferon-alpha n1 and concomitant zidovudine in patients with AIDS-related Kaposi's sarcoma

To determine the safety, maximum tolerated dose, and preliminary efficacy of concomitant interferon-alpha and zidovudine therapy in AIDS-related Kaposi's sarcoma (KS), 56 patients with biopsy-proven KS and documented human immunodeficiency virus type 1 (HIV) infection were enrolled into a phase...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1988) 1991, Vol.4 (1), p.1
Hauptverfasser:	Fischl, M A, Uttamchandani, R B, Resnick, L, Agarwal, R, Fletcher, M A, Patrone-Reese, J, Dearmas, L, Chidekel, J, McCann, M, Myers, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - therapy Adult Anemia - chemically induced Bisexuality CD4-Positive T-Lymphocytes Combined Modality Therapy Drug Evaluation Follow-Up Studies HIV Antigens - analysis HIV-1 - immunology Homosexuality Humans Injections, Intramuscular Interferon alpha-2 Interferon Type I - administration & dosage Interferon Type I - adverse effects Interferon Type I - therapeutic use Interferon-alpha - administration & dosage Interferon-alpha - adverse effects Interferon-alpha - therapeutic use Leukocyte Count Liver - drug effects Male Neutropenia - chemically induced Opportunistic Infections - complications Recombinant Proteins Sarcoma, Kaposi - etiology Sarcoma, Kaposi - therapy Zidovudine - administration & dosage Zidovudine - adverse effects Zidovudine - therapeutic use
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