Evaluation of a two-generation reproduction toxicity study adding endpoints to detect endocrine disrupting activity using vinclozolin

A two-generation reproduction toxicity study in rats adding extra endpoints to detect endocrine disrupting activity was conducted using vinclozolin by dietary administration at 0, 40, 200, and 1000 ppm, for investigation of its utility. The extra endpoints included anogenital distance (AGD), nipple...

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Veröffentlicht in:	Journal of toxicological sciences 2005-12, Vol.30 Spec No., p.163
Hauptverfasser:	Matsuura, Ikuo, Saitoh, Tetsuji, Ashina, Michiko, Wako, Yumi, Iwata, Hiroshi, Toyota, Naoto, Ishizuka, Yoshihito, Namiki, Masato, Hoshino, Nobuhito, Tsuchitani, Minoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Dose-Response Relationship, Drug Endocrine Disruptors - toxicity Endpoint Determination Female Male Oxazoles - toxicity Pregnancy Prenatal Exposure Delayed Effects - chemically induced Rats Rats, Inbred Strains Reproduction - drug effects Toxicity Tests, Chronic - methods
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