The effects of mefenamic acid on hematocrit of the lizard, Uromastix hardwickii
Mefenamic acid is an analgesic, antipyretic and anti-inflammatory agent. In addition induces several hematological disturbances. Present study was conducted to determine the alterations in blood PCV of the lizard Uromastix hardwickii after the administration of 7.1 mg/ml; 10.5 mg/ml and 14.0 mg/ml m...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2006-01, Vol.19 (1), p.48 |
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| creator | Ahmed, Mahmood Ahmad, Mansoor Hasan, Ruqaiya Qureshi, Anila Ahmed, Zulfiqar |
| description | Mefenamic acid is an analgesic, antipyretic and anti-inflammatory agent. In addition induces several hematological disturbances. Present study was conducted to determine the alterations in blood PCV of the lizard Uromastix hardwickii after the administration of 7.1 mg/ml; 10.5 mg/ml and 14.0 mg/ml mefenamic acid per individual per day for 12 days to 3 test groups. The mean values of PCV were 15.5+/-0.81%, 14.5+/-0.25% and 12.0+/-0.25% for 3 test groups respectively in comparison to 23.5+/-0.40% for control. Thus a significant dose dependant reduction in mean PCV per cent following the administration of mefenamic acid for 12 days indicates the extra vascular hemolysis due to destructive change in the red cell membrane through autoantibody mechanism. |
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In addition induces several hematological disturbances. Present study was conducted to determine the alterations in blood PCV of the lizard Uromastix hardwickii after the administration of 7.1 mg/ml; 10.5 mg/ml and 14.0 mg/ml mefenamic acid per individual per day for 12 days to 3 test groups. The mean values of PCV were 15.5+/-0.81%, 14.5+/-0.25% and 12.0+/-0.25% for 3 test groups respectively in comparison to 23.5+/-0.40% for control. Thus a significant dose dependant reduction in mean PCV per cent following the administration of mefenamic acid for 12 days indicates the extra vascular hemolysis due to destructive change in the red cell membrane through autoantibody mechanism.</description><subject>Anemia, Hemolytic, Autoimmune - chemically induced</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Hematocrit</subject><subject>Lizards - blood</subject><subject>Mefenamic Acid - pharmacology</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j8tKAzEYhbNQ2lr7CpIHcGCSTP40SyneoNBNC-5KLn-YaNMZkoiXp7dSXR0O3-GDc0FmrGWsgZa9TMlVKa9tC53WekKmDEDwTooZ2Wx7pBgCulroEGjCgEeToqPGRU-HI-0xmTq4HOsvr6f5IX6b7G_pLg_JlBo_aX_qH9G9xXhNLoM5FFz85ZzsHu63q6dmvXl8Xt2tm5HxrjbWMvS2M8o7AK0wSLQSlFx6lApBADPABXfKGVzqEEB4Hzg6DyA5WhBzcnP2ju82od-POSaTv_b_z8QPeoxKug</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Ahmed, Mahmood</creator><creator>Ahmad, Mansoor</creator><creator>Hasan, Ruqaiya</creator><creator>Qureshi, Anila</creator><creator>Ahmed, Zulfiqar</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200601</creationdate><title>The effects of mefenamic acid on hematocrit of the lizard, Uromastix hardwickii</title><author>Ahmed, Mahmood ; Ahmad, Mansoor ; Hasan, Ruqaiya ; Qureshi, Anila ; Ahmed, Zulfiqar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p124t-bb1edb4a7dc6697ef5eb56758de57e6361a6232c7cae89ff63ddf2ecd6652eb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Anemia, Hemolytic, Autoimmune - chemically induced</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Hematocrit</topic><topic>Lizards - blood</topic><topic>Mefenamic Acid - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmed, Mahmood</creatorcontrib><creatorcontrib>Ahmad, Mansoor</creatorcontrib><creatorcontrib>Hasan, Ruqaiya</creatorcontrib><creatorcontrib>Qureshi, Anila</creatorcontrib><creatorcontrib>Ahmed, Zulfiqar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmed, Mahmood</au><au>Ahmad, Mansoor</au><au>Hasan, Ruqaiya</au><au>Qureshi, Anila</au><au>Ahmed, Zulfiqar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of mefenamic acid on hematocrit of the lizard, Uromastix hardwickii</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2006-01</date><risdate>2006</risdate><volume>19</volume><issue>1</issue><spage>48</spage><pages>48-</pages><issn>1011-601X</issn><abstract>Mefenamic acid is an analgesic, antipyretic and anti-inflammatory agent. In addition induces several hematological disturbances. Present study was conducted to determine the alterations in blood PCV of the lizard Uromastix hardwickii after the administration of 7.1 mg/ml; 10.5 mg/ml and 14.0 mg/ml mefenamic acid per individual per day for 12 days to 3 test groups. The mean values of PCV were 15.5+/-0.81%, 14.5+/-0.25% and 12.0+/-0.25% for 3 test groups respectively in comparison to 23.5+/-0.40% for control. Thus a significant dose dependant reduction in mean PCV per cent following the administration of mefenamic acid for 12 days indicates the extra vascular hemolysis due to destructive change in the red cell membrane through autoantibody mechanism.</abstract><cop>Pakistan</cop><pmid>16632453</pmid></addata></record> |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ） |
| subjects | Anemia, Hemolytic, Autoimmune - chemically induced Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Hematocrit Lizards - blood Mefenamic Acid - pharmacology |
| title | The effects of mefenamic acid on hematocrit of the lizard, Uromastix hardwickii |
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