Comparative Evaluation of FET and FDG for Differentiating Lung Carcinoma from Inflammation in Mice
Background: Clinical FDG/PET (2-deoxy-2- 18 F-fluoro-D-glucose/positron emission tomography) studies encounter difficulties in detecting early stage lung cancers. The aim of this study was to evaluate the ability of O-2- 18 F-fluoroethyl-L-tyrosine (FET) and FDG to differentiate between inflammation...
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| Veröffentlicht in: | Anticancer research 2006-03, Vol.26 (2A), p.917-925 |
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| creator | CHANG, Chih-Hsien WANG, Hsin-Ell FU, Ying-Kai WU, Shi-Yuan FAN, Kuo-Hsien TSAI, Tung-Hu LEE, Te-Wei CHANG, Shiang-Rong LIU, Ren-Shyan CHEN, Chieh-Fu CHEN, Chin-Hsiung |
| description | Background: Clinical FDG/PET (2-deoxy-2- 18 F-fluoro-D-glucose/positron emission tomography) studies encounter difficulties in detecting early stage lung cancers. The
aim of this study was to evaluate the ability of O-2- 18 F-fluoroethyl-L-tyrosine (FET) and FDG to differentiate between inflammation and lung carcinoma in mice. Materials and Methods:
Sixty-four C57BL/6 mice were inoculated with 2x10 6 LLC1 lung carcinoma cells in the right hind flank on day 0 and were then injected with 0.1 mL turpentine in the left thigh
muscle on day 3. The progress of inflammation and tumor in mice was longitudinally monitored by FDG/microPET. The biodistribution
study, pharmacokinetic evaluation and whole-body autoradiography of FET and FDG were performed on day 8 after tumor inoculation.
Results: The FDG uptakes in tumor and inflammatory lesions were 4.42-fold and 3.53-fold (n=4) higher, respectively, than that
in muscle at 90 min post-injection and the tumor-to-inflammation ratio was 1.25. For FET/microPET, the tumor uptake was 2.07-fold
and 2.07-fold (n=4) higher than those in muscle and inflammatory lesions at 90 min post-injection, respectively. The distribution
half-life (t 1/2,α ) and the elimination half-life (t 1/2,β ) of FET were 39 min and 205 min, respectively, in mice. Conclusion: FDG delineated both tumor and inflammation, while FET
accumulated in tumor to a significantly higher extent. Our results demonstrated the potential of FET to distinguish epidermoid
lung carcinoma from inflammatory lesions in mice. |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_pasca</sourceid><recordid>TN_cdi_pubmed_primary_16619487</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16619487</sourcerecordid><originalsourceid>FETCH-LOGICAL-h269t-b242777e2e6445acfed08b566cf7981fa227561bb433330c950499e9928326433</originalsourceid><addsrcrecordid>eNpFj8tqwzAQRUVpadK0v1C06dIgyZZkLYPzhJRu2rUZy1KsYslBTlL69xUkJbO4dxgOB-YOTalUNJM8J_doShgnmSSET9DTOH4TIoQq80c0oUJQVZRyippq8AeIcHRng5dn6E9pHQIeLF4tPzGEFq8Wa2yHiBfOWhNNOLqEhD3enVJUELULgwds4-DxNtgevL84XMDvTptn9GChH83LtWfoK6mrTbb7WG-r-S7rmFDHrGEFk1IaZkRRcNDWtKRsuBDaSlVSC4xJLmjTFHkaohUnhVJGKVbmTKTjDL1evIdT401bH6LzEH_r_2cT8HYFYNTQ2whBu_HGSSFLRdWN69y--3HR1KOHvk_avIbIRM3mtaIy_wMeBWm9</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Comparative Evaluation of FET and FDG for Differentiating Lung Carcinoma from Inflammation in Mice</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>CHANG, Chih-Hsien ; WANG, Hsin-Ell ; FU, Ying-Kai ; WU, Shi-Yuan ; FAN, Kuo-Hsien ; TSAI, Tung-Hu ; LEE, Te-Wei ; CHANG, Shiang-Rong ; LIU, Ren-Shyan ; CHEN, Chieh-Fu ; CHEN, Chin-Hsiung</creator><creatorcontrib>CHANG, Chih-Hsien ; WANG, Hsin-Ell ; FU, Ying-Kai ; WU, Shi-Yuan ; FAN, Kuo-Hsien ; TSAI, Tung-Hu ; LEE, Te-Wei ; CHANG, Shiang-Rong ; LIU, Ren-Shyan ; CHEN, Chieh-Fu ; CHEN, Chin-Hsiung</creatorcontrib><description>Background: Clinical FDG/PET (2-deoxy-2- 18 F-fluoro-D-glucose/positron emission tomography) studies encounter difficulties in detecting early stage lung cancers. The
aim of this study was to evaluate the ability of O-2- 18 F-fluoroethyl-L-tyrosine (FET) and FDG to differentiate between inflammation and lung carcinoma in mice. Materials and Methods:
Sixty-four C57BL/6 mice were inoculated with 2x10 6 LLC1 lung carcinoma cells in the right hind flank on day 0 and were then injected with 0.1 mL turpentine in the left thigh
muscle on day 3. The progress of inflammation and tumor in mice was longitudinally monitored by FDG/microPET. The biodistribution
study, pharmacokinetic evaluation and whole-body autoradiography of FET and FDG were performed on day 8 after tumor inoculation.
Results: The FDG uptakes in tumor and inflammatory lesions were 4.42-fold and 3.53-fold (n=4) higher, respectively, than that
in muscle at 90 min post-injection and the tumor-to-inflammation ratio was 1.25. For FET/microPET, the tumor uptake was 2.07-fold
and 2.07-fold (n=4) higher than those in muscle and inflammatory lesions at 90 min post-injection, respectively. The distribution
half-life (t 1/2,α ) and the elimination half-life (t 1/2,β ) of FET were 39 min and 205 min, respectively, in mice. Conclusion: FDG delineated both tumor and inflammation, while FET
accumulated in tumor to a significantly higher extent. Our results demonstrated the potential of FET to distinguish epidermoid
lung carcinoma from inflammatory lesions in mice.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 16619487</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Animals ; Autoradiography - methods ; Biological and medical sciences ; Carcinoma, Lewis Lung - diagnostic imaging ; Carcinoma, Lewis Lung - metabolism ; Carcinoma, Non-Small-Cell Lung - diagnostic imaging ; Carcinoma, Non-Small-Cell Lung - metabolism ; Diagnosis, Differential ; Fluorine Radioisotopes ; Fluorodeoxyglucose F18 - pharmacokinetics ; Image Processing, Computer-Assisted ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - metabolism ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Pneumology ; Pneumonia - chemically induced ; Pneumonia - diagnostic imaging ; Pneumonia - metabolism ; Positron-Emission Tomography - methods ; Radiopharmaceuticals - pharmacokinetics ; Tumors ; Tumors of the respiratory system and mediastinum ; Turpentine ; Tyrosine - analogs & derivatives ; Tyrosine - pharmacokinetics</subject><ispartof>Anticancer research, 2006-03, Vol.26 (2A), p.917-925</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17678919$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16619487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHANG, Chih-Hsien</creatorcontrib><creatorcontrib>WANG, Hsin-Ell</creatorcontrib><creatorcontrib>FU, Ying-Kai</creatorcontrib><creatorcontrib>WU, Shi-Yuan</creatorcontrib><creatorcontrib>FAN, Kuo-Hsien</creatorcontrib><creatorcontrib>TSAI, Tung-Hu</creatorcontrib><creatorcontrib>LEE, Te-Wei</creatorcontrib><creatorcontrib>CHANG, Shiang-Rong</creatorcontrib><creatorcontrib>LIU, Ren-Shyan</creatorcontrib><creatorcontrib>CHEN, Chieh-Fu</creatorcontrib><creatorcontrib>CHEN, Chin-Hsiung</creatorcontrib><title>Comparative Evaluation of FET and FDG for Differentiating Lung Carcinoma from Inflammation in Mice</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: Clinical FDG/PET (2-deoxy-2- 18 F-fluoro-D-glucose/positron emission tomography) studies encounter difficulties in detecting early stage lung cancers. The
aim of this study was to evaluate the ability of O-2- 18 F-fluoroethyl-L-tyrosine (FET) and FDG to differentiate between inflammation and lung carcinoma in mice. Materials and Methods:
Sixty-four C57BL/6 mice were inoculated with 2x10 6 LLC1 lung carcinoma cells in the right hind flank on day 0 and were then injected with 0.1 mL turpentine in the left thigh
muscle on day 3. The progress of inflammation and tumor in mice was longitudinally monitored by FDG/microPET. The biodistribution
study, pharmacokinetic evaluation and whole-body autoradiography of FET and FDG were performed on day 8 after tumor inoculation.
Results: The FDG uptakes in tumor and inflammatory lesions were 4.42-fold and 3.53-fold (n=4) higher, respectively, than that
in muscle at 90 min post-injection and the tumor-to-inflammation ratio was 1.25. For FET/microPET, the tumor uptake was 2.07-fold
and 2.07-fold (n=4) higher than those in muscle and inflammatory lesions at 90 min post-injection, respectively. The distribution
half-life (t 1/2,α ) and the elimination half-life (t 1/2,β ) of FET were 39 min and 205 min, respectively, in mice. Conclusion: FDG delineated both tumor and inflammation, while FET
accumulated in tumor to a significantly higher extent. Our results demonstrated the potential of FET to distinguish epidermoid
lung carcinoma from inflammatory lesions in mice.</description><subject>Animals</subject><subject>Autoradiography - methods</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Lewis Lung - diagnostic imaging</subject><subject>Carcinoma, Lewis Lung - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>Diagnosis, Differential</subject><subject>Fluorine Radioisotopes</subject><subject>Fluorodeoxyglucose F18 - pharmacokinetics</subject><subject>Image Processing, Computer-Assisted</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Pneumology</subject><subject>Pneumonia - chemically induced</subject><subject>Pneumonia - diagnostic imaging</subject><subject>Pneumonia - metabolism</subject><subject>Positron-Emission Tomography - methods</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Tumors</subject><subject>Tumors of the respiratory system and mediastinum</subject><subject>Turpentine</subject><subject>Tyrosine - analogs & derivatives</subject><subject>Tyrosine - pharmacokinetics</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFj8tqwzAQRUVpadK0v1C06dIgyZZkLYPzhJRu2rUZy1KsYslBTlL69xUkJbO4dxgOB-YOTalUNJM8J_doShgnmSSET9DTOH4TIoQq80c0oUJQVZRyippq8AeIcHRng5dn6E9pHQIeLF4tPzGEFq8Wa2yHiBfOWhNNOLqEhD3enVJUELULgwds4-DxNtgevL84XMDvTptn9GChH83LtWfoK6mrTbb7WG-r-S7rmFDHrGEFk1IaZkRRcNDWtKRsuBDaSlVSC4xJLmjTFHkaohUnhVJGKVbmTKTjDL1evIdT401bH6LzEH_r_2cT8HYFYNTQ2whBu_HGSSFLRdWN69y--3HR1KOHvk_avIbIRM3mtaIy_wMeBWm9</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>CHANG, Chih-Hsien</creator><creator>WANG, Hsin-Ell</creator><creator>FU, Ying-Kai</creator><creator>WU, Shi-Yuan</creator><creator>FAN, Kuo-Hsien</creator><creator>TSAI, Tung-Hu</creator><creator>LEE, Te-Wei</creator><creator>CHANG, Shiang-Rong</creator><creator>LIU, Ren-Shyan</creator><creator>CHEN, Chieh-Fu</creator><creator>CHEN, Chin-Hsiung</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20060301</creationdate><title>Comparative Evaluation of FET and FDG for Differentiating Lung Carcinoma from Inflammation in Mice</title><author>CHANG, Chih-Hsien ; WANG, Hsin-Ell ; FU, Ying-Kai ; WU, Shi-Yuan ; FAN, Kuo-Hsien ; TSAI, Tung-Hu ; LEE, Te-Wei ; CHANG, Shiang-Rong ; LIU, Ren-Shyan ; CHEN, Chieh-Fu ; CHEN, Chin-Hsiung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h269t-b242777e2e6445acfed08b566cf7981fa227561bb433330c950499e9928326433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Autoradiography - methods</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Lewis Lung - diagnostic imaging</topic><topic>Carcinoma, Lewis Lung - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</topic><topic>Carcinoma, Non-Small-Cell Lung - metabolism</topic><topic>Diagnosis, Differential</topic><topic>Fluorine Radioisotopes</topic><topic>Fluorodeoxyglucose F18 - pharmacokinetics</topic><topic>Image Processing, Computer-Assisted</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Pneumology</topic><topic>Pneumonia - chemically induced</topic><topic>Pneumonia - diagnostic imaging</topic><topic>Pneumonia - metabolism</topic><topic>Positron-Emission Tomography - methods</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Tumors</topic><topic>Tumors of the respiratory system and mediastinum</topic><topic>Turpentine</topic><topic>Tyrosine - analogs & derivatives</topic><topic>Tyrosine - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHANG, Chih-Hsien</creatorcontrib><creatorcontrib>WANG, Hsin-Ell</creatorcontrib><creatorcontrib>FU, Ying-Kai</creatorcontrib><creatorcontrib>WU, Shi-Yuan</creatorcontrib><creatorcontrib>FAN, Kuo-Hsien</creatorcontrib><creatorcontrib>TSAI, Tung-Hu</creatorcontrib><creatorcontrib>LEE, Te-Wei</creatorcontrib><creatorcontrib>CHANG, Shiang-Rong</creatorcontrib><creatorcontrib>LIU, Ren-Shyan</creatorcontrib><creatorcontrib>CHEN, Chieh-Fu</creatorcontrib><creatorcontrib>CHEN, Chin-Hsiung</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHANG, Chih-Hsien</au><au>WANG, Hsin-Ell</au><au>FU, Ying-Kai</au><au>WU, Shi-Yuan</au><au>FAN, Kuo-Hsien</au><au>TSAI, Tung-Hu</au><au>LEE, Te-Wei</au><au>CHANG, Shiang-Rong</au><au>LIU, Ren-Shyan</au><au>CHEN, Chieh-Fu</au><au>CHEN, Chin-Hsiung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Evaluation of FET and FDG for Differentiating Lung Carcinoma from Inflammation in Mice</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>26</volume><issue>2A</issue><spage>917</spage><epage>925</epage><pages>917-925</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: Clinical FDG/PET (2-deoxy-2- 18 F-fluoro-D-glucose/positron emission tomography) studies encounter difficulties in detecting early stage lung cancers. The
aim of this study was to evaluate the ability of O-2- 18 F-fluoroethyl-L-tyrosine (FET) and FDG to differentiate between inflammation and lung carcinoma in mice. Materials and Methods:
Sixty-four C57BL/6 mice were inoculated with 2x10 6 LLC1 lung carcinoma cells in the right hind flank on day 0 and were then injected with 0.1 mL turpentine in the left thigh
muscle on day 3. The progress of inflammation and tumor in mice was longitudinally monitored by FDG/microPET. The biodistribution
study, pharmacokinetic evaluation and whole-body autoradiography of FET and FDG were performed on day 8 after tumor inoculation.
Results: The FDG uptakes in tumor and inflammatory lesions were 4.42-fold and 3.53-fold (n=4) higher, respectively, than that
in muscle at 90 min post-injection and the tumor-to-inflammation ratio was 1.25. For FET/microPET, the tumor uptake was 2.07-fold
and 2.07-fold (n=4) higher than those in muscle and inflammatory lesions at 90 min post-injection, respectively. The distribution
half-life (t 1/2,α ) and the elimination half-life (t 1/2,β ) of FET were 39 min and 205 min, respectively, in mice. Conclusion: FDG delineated both tumor and inflammation, while FET
accumulated in tumor to a significantly higher extent. Our results demonstrated the potential of FET to distinguish epidermoid
lung carcinoma from inflammatory lesions in mice.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>16619487</pmid><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Autoradiography - methods Biological and medical sciences Carcinoma, Lewis Lung - diagnostic imaging Carcinoma, Lewis Lung - metabolism Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Non-Small-Cell Lung - metabolism Diagnosis, Differential Fluorine Radioisotopes Fluorodeoxyglucose F18 - pharmacokinetics Image Processing, Computer-Assisted Lung Neoplasms - diagnostic imaging Lung Neoplasms - metabolism Male Medical sciences Mice Mice, Inbred C57BL Pneumology Pneumonia - chemically induced Pneumonia - diagnostic imaging Pneumonia - metabolism Positron-Emission Tomography - methods Radiopharmaceuticals - pharmacokinetics Tumors Tumors of the respiratory system and mediastinum Turpentine Tyrosine - analogs & derivatives Tyrosine - pharmacokinetics |
| title | Comparative Evaluation of FET and FDG for Differentiating Lung Carcinoma from Inflammation in Mice |
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