The effect of hypoxia on photocytotoxicity of TICS tricarbocyanine dye in vitro
To evaluate the effect of cell oxygenation on photocytotoxicity of a novel tricarbocyanine indolenine dye covalently bound to glucose (TICS). HeLa cells were incubated with 5 microM TICS, 2 h later irradiated by laser at 740 nm with a light dose of 10 J/cm(2), delivered at a power density of 10, 20,...
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| Veröffentlicht in: | Experimental oncology 2006-03, Vol.28 (1), p.80 |
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| container_title | Experimental oncology |
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| creator | Istomin, Y P Alexandrova, E N Zhavrid, E A Voropay, E S Samtsov, M P Kaplevsky, K N Lugovsky, A P Lugovsky, A A |
| description | To evaluate the effect of cell oxygenation on photocytotoxicity of a novel tricarbocyanine indolenine dye covalently bound to glucose (TICS).
HeLa cells were incubated with 5 microM TICS, 2 h later irradiated by laser at 740 nm with a light dose of 10 J/cm(2), delivered at a power density of 10, 20, 25 or 30 mW/cm(2), in air or in argon atmosphere, and then scored for viability.
The photocytotoxicity of TICS increased dramatically as the power density was reduced. Under hypoxia TICS-photosensitized cell death was determined but its value was lowered, compared to photoirradiation in the air.
Photosensitizing effect of TICS is only partially dependent on the oxygenation of tumor cells. |
| format | Article |
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HeLa cells were incubated with 5 microM TICS, 2 h later irradiated by laser at 740 nm with a light dose of 10 J/cm(2), delivered at a power density of 10, 20, 25 or 30 mW/cm(2), in air or in argon atmosphere, and then scored for viability.
The photocytotoxicity of TICS increased dramatically as the power density was reduced. Under hypoxia TICS-photosensitized cell death was determined but its value was lowered, compared to photoirradiation in the air.
Photosensitizing effect of TICS is only partially dependent on the oxygenation of tumor cells.</description><identifier>ISSN: 1812-9269</identifier><identifier>PMID: 16614714</identifier><language>eng</language><publisher>Ukraine</publisher><subject>Cell Hypoxia ; Cell Survival - drug effects ; Cell Survival - radiation effects ; HeLa Cells ; Humans ; Kinetics ; Photochemotherapy - methods</subject><ispartof>Experimental oncology, 2006-03, Vol.28 (1), p.80</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16614714$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Istomin, Y P</creatorcontrib><creatorcontrib>Alexandrova, E N</creatorcontrib><creatorcontrib>Zhavrid, E A</creatorcontrib><creatorcontrib>Voropay, E S</creatorcontrib><creatorcontrib>Samtsov, M P</creatorcontrib><creatorcontrib>Kaplevsky, K N</creatorcontrib><creatorcontrib>Lugovsky, A P</creatorcontrib><creatorcontrib>Lugovsky, A A</creatorcontrib><title>The effect of hypoxia on photocytotoxicity of TICS tricarbocyanine dye in vitro</title><title>Experimental oncology</title><addtitle>Exp Oncol</addtitle><description>To evaluate the effect of cell oxygenation on photocytotoxicity of a novel tricarbocyanine indolenine dye covalently bound to glucose (TICS).
HeLa cells were incubated with 5 microM TICS, 2 h later irradiated by laser at 740 nm with a light dose of 10 J/cm(2), delivered at a power density of 10, 20, 25 or 30 mW/cm(2), in air or in argon atmosphere, and then scored for viability.
The photocytotoxicity of TICS increased dramatically as the power density was reduced. Under hypoxia TICS-photosensitized cell death was determined but its value was lowered, compared to photoirradiation in the air.
Photosensitizing effect of TICS is only partially dependent on the oxygenation of tumor cells.</description><subject>Cell Hypoxia</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - radiation effects</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Photochemotherapy - methods</subject><issn>1812-9269</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j8tKAzEYhbNQbK2-guQFBnJPZimDl0Khi86-5PIPE7GTMBOleXtb1M354Hxw4NygNTWUNS1T7QrdL8sHIUq2StyhFVWKCk3FGu37ETAMA_iC04DHmtM5WpwmnMdUkq_lkufoY6lX32-7Ay5z9HZ2F2mnOAEOFXCc8Hcsc3pAt4P9XODxjxt0eH3pu_dmt3_bds-7Jre8NFRKqYA4y5z1wWihGZOaUGm5UsIGQ0ngMhDtrh0lxhEGkvJggjEAfIOeflfzlztBOOY5nuxcj_-_-A-oeUiX</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Istomin, Y P</creator><creator>Alexandrova, E N</creator><creator>Zhavrid, E A</creator><creator>Voropay, E S</creator><creator>Samtsov, M P</creator><creator>Kaplevsky, K N</creator><creator>Lugovsky, A P</creator><creator>Lugovsky, A A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200603</creationdate><title>The effect of hypoxia on photocytotoxicity of TICS tricarbocyanine dye in vitro</title><author>Istomin, Y P ; Alexandrova, E N ; Zhavrid, E A ; Voropay, E S ; Samtsov, M P ; Kaplevsky, K N ; Lugovsky, A P ; Lugovsky, A A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p93t-15556e0ba2bacd87472257015a3664ad810d35d07b015a108b02e513d8d88ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Cell Hypoxia</topic><topic>Cell Survival - drug effects</topic><topic>Cell Survival - radiation effects</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Photochemotherapy - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Istomin, Y P</creatorcontrib><creatorcontrib>Alexandrova, E N</creatorcontrib><creatorcontrib>Zhavrid, E A</creatorcontrib><creatorcontrib>Voropay, E S</creatorcontrib><creatorcontrib>Samtsov, M P</creatorcontrib><creatorcontrib>Kaplevsky, K N</creatorcontrib><creatorcontrib>Lugovsky, A P</creatorcontrib><creatorcontrib>Lugovsky, A A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Experimental oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Istomin, Y P</au><au>Alexandrova, E N</au><au>Zhavrid, E A</au><au>Voropay, E S</au><au>Samtsov, M P</au><au>Kaplevsky, K N</au><au>Lugovsky, A P</au><au>Lugovsky, A A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of hypoxia on photocytotoxicity of TICS tricarbocyanine dye in vitro</atitle><jtitle>Experimental oncology</jtitle><addtitle>Exp Oncol</addtitle><date>2006-03</date><risdate>2006</risdate><volume>28</volume><issue>1</issue><spage>80</spage><pages>80-</pages><issn>1812-9269</issn><abstract>To evaluate the effect of cell oxygenation on photocytotoxicity of a novel tricarbocyanine indolenine dye covalently bound to glucose (TICS).
HeLa cells were incubated with 5 microM TICS, 2 h later irradiated by laser at 740 nm with a light dose of 10 J/cm(2), delivered at a power density of 10, 20, 25 or 30 mW/cm(2), in air or in argon atmosphere, and then scored for viability.
The photocytotoxicity of TICS increased dramatically as the power density was reduced. Under hypoxia TICS-photosensitized cell death was determined but its value was lowered, compared to photoirradiation in the air.
Photosensitizing effect of TICS is only partially dependent on the oxygenation of tumor cells.</abstract><cop>Ukraine</cop><pmid>16614714</pmid></addata></record> |
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| ispartof | Experimental oncology, 2006-03, Vol.28 (1), p.80 |
| issn | 1812-9269 |
| language | eng |
| recordid | cdi_pubmed_primary_16614714 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Cell Hypoxia Cell Survival - drug effects Cell Survival - radiation effects HeLa Cells Humans Kinetics Photochemotherapy - methods |
| title | The effect of hypoxia on photocytotoxicity of TICS tricarbocyanine dye in vitro |
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