Glucose lowering efficacy of the aqueous stem bark extract of Trema orientalis (Linn) Blume in normal and streptozotocin diabetic rats
The glucose-lowering efficacy of the aqueous stem bark extract of Trema orientalis (Ulmaceae) was evaluated both in normal and streptozotocin-induced diabetic rats. In normoglycemic rats, the single oral administration of the aqueous extract of T. orientalis failed to reduce blood glucose levels whi...
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| Veröffentlicht in: | Pharmazie 2006-03, Vol.61 (3), p.233-236 |
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| creator | Dimo, T. Ngueguim, F. T. Kamtchouing, P. Dongo, E. Tan, P. V. |
| description | The glucose-lowering efficacy of the aqueous stem bark extract of Trema orientalis (Ulmaceae) was evaluated both in normal and streptozotocin-induced diabetic rats. In normoglycemic rats, the single oral administration of the aqueous extract of T. orientalis failed to
reduce blood glucose levels while in STZ-diabetic rats, the plant extract (38-300 mg/kg) exhibited significant hypoglycaemic activity with a maximum effect of 29.67%, 5 hours after administration of the 75 mg/kg dose when compared with the diabetic untreated group. Glibenclamide
was not able to lower blood glucose in STZ-diabetic rats, while it significantly lowered the blood sugar in normoglycemic rats. The hypoglycaemic property of T. orientalis was also assessed by an oral glucose tolerance test (OGTT) in STZ-diabetic rats. The aqueous extract of T. orientalis
and the reference drug, glibenclamide, (10 mg/kg) produced significant blood glucose lowering effects in the diabetic rats when compared to the diabetic controls. One week after repeated administration of T. orientalis extract, blood glucose levels were significantly decreased (p <
0.05) and still remained low after 2 weeks (p < 0.01). The results indicated that T. orientalis stem bark extract significantly reduces blood glucose in STZ-induced diabetic rats by a mechanism different from that of sulfonylurea agents. The present investigation provides pharmacological
evidence that the use of this plant extract in traditional medicine for cardiovascular disease can be of benefit particulary in diabetic patients. |
| format | Article |
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reduce blood glucose levels while in STZ-diabetic rats, the plant extract (38-300 mg/kg) exhibited significant hypoglycaemic activity with a maximum effect of 29.67%, 5 hours after administration of the 75 mg/kg dose when compared with the diabetic untreated group. Glibenclamide
was not able to lower blood glucose in STZ-diabetic rats, while it significantly lowered the blood sugar in normoglycemic rats. The hypoglycaemic property of T. orientalis was also assessed by an oral glucose tolerance test (OGTT) in STZ-diabetic rats. The aqueous extract of T. orientalis
and the reference drug, glibenclamide, (10 mg/kg) produced significant blood glucose lowering effects in the diabetic rats when compared to the diabetic controls. One week after repeated administration of T. orientalis extract, blood glucose levels were significantly decreased (p <
0.05) and still remained low after 2 weeks (p < 0.01). The results indicated that T. orientalis stem bark extract significantly reduces blood glucose in STZ-induced diabetic rats by a mechanism different from that of sulfonylurea agents. The present investigation provides pharmacological
evidence that the use of this plant extract in traditional medicine for cardiovascular disease can be of benefit particulary in diabetic patients.</description><identifier>ISSN: 0031-7144</identifier><identifier>PMID: 16599266</identifier><language>eng</language><publisher>Germany: Govi-Verlag</publisher><subject>Animals ; Blood Glucose - metabolism ; Body Weight - drug effects ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - chemically induced ; Diabetes Mellitus, Type 1 - drug therapy ; Drinking - drug effects ; Eating - drug effects ; Glucose Tolerance Test ; Hypoglycemic Agents - pharmacology ; Hypoglycemic Agents - therapeutic use ; Male ; Plant Bark - chemistry ; Plant Extracts - pharmacology ; Rats ; Rats, Wistar ; Trema - chemistry</subject><ispartof>Pharmazie, 2006-03, Vol.61 (3), p.233-236</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>288,314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16599266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dimo, T.</creatorcontrib><creatorcontrib>Ngueguim, F. T.</creatorcontrib><creatorcontrib>Kamtchouing, P.</creatorcontrib><creatorcontrib>Dongo, E.</creatorcontrib><creatorcontrib>Tan, P. V.</creatorcontrib><title>Glucose lowering efficacy of the aqueous stem bark extract of Trema orientalis (Linn) Blume in normal and streptozotocin diabetic rats</title><title>Pharmazie</title><addtitle>Pharmazie</addtitle><description>The glucose-lowering efficacy of the aqueous stem bark extract of Trema orientalis (Ulmaceae) was evaluated both in normal and streptozotocin-induced diabetic rats. In normoglycemic rats, the single oral administration of the aqueous extract of T. orientalis failed to
reduce blood glucose levels while in STZ-diabetic rats, the plant extract (38-300 mg/kg) exhibited significant hypoglycaemic activity with a maximum effect of 29.67%, 5 hours after administration of the 75 mg/kg dose when compared with the diabetic untreated group. Glibenclamide
was not able to lower blood glucose in STZ-diabetic rats, while it significantly lowered the blood sugar in normoglycemic rats. The hypoglycaemic property of T. orientalis was also assessed by an oral glucose tolerance test (OGTT) in STZ-diabetic rats. The aqueous extract of T. orientalis
and the reference drug, glibenclamide, (10 mg/kg) produced significant blood glucose lowering effects in the diabetic rats when compared to the diabetic controls. One week after repeated administration of T. orientalis extract, blood glucose levels were significantly decreased (p <
0.05) and still remained low after 2 weeks (p < 0.01). The results indicated that T. orientalis stem bark extract significantly reduces blood glucose in STZ-induced diabetic rats by a mechanism different from that of sulfonylurea agents. The present investigation provides pharmacological
evidence that the use of this plant extract in traditional medicine for cardiovascular disease can be of benefit particulary in diabetic patients.</description><subject>Animals</subject><subject>Blood Glucose - metabolism</subject><subject>Body Weight - drug effects</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - chemically induced</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>Drinking - drug effects</subject><subject>Eating - drug effects</subject><subject>Glucose Tolerance Test</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Male</subject><subject>Plant Bark - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Trema - chemistry</subject><issn>0031-7144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctOwzAQRbMAQXn8AvISFpVsx3GSJc-CVIkNrK1JMi4uiV1sB2g_gO_GpbBkNjPSXB3NvbOXTSjN2bRkQhxmRyEsKeWSy-ogO2SyqGsu5ST7mvVj6wKS3n2gN3ZBUGvTQrsmTpP4ggTeRnRjICHiQBrwrwQ_o4c2bgVPHgcgzhu0EXoTyPncWHtBrvpxQGIssc4P0BOwXQJ4XEW3cdG1adMZaDCalniI4STb19AHPP3tx9nz3e3T9f10_jh7uL6cT00ueJx2Oq-6opNa6KbkXd20TMpSIs8poyAAWFFqaDiTvOCUCS2rAkUldcWqohFlfpyd7birsRmwUytvBvBr9RdIEtzsBCmKrSe1dKO36SS1cO9GrV4g-dkoTqlU9Kck-x1orsDH1JlImMd_MKbdkba_2b5GvUtm8wTkjFYsV7QuatWhhrGPKoJXi40KifgNr4yNxw</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Dimo, T.</creator><creator>Ngueguim, F. T.</creator><creator>Kamtchouing, P.</creator><creator>Dongo, E.</creator><creator>Tan, P. V.</creator><general>Govi-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20060301</creationdate><title>Glucose lowering efficacy of the aqueous stem bark extract of Trema orientalis (Linn) Blume in normal and streptozotocin diabetic rats</title><author>Dimo, T. ; Ngueguim, F. T. ; Kamtchouing, P. ; Dongo, E. ; Tan, P. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i342t-df38d5d6f4fb72d9bc16676e23010a4aa157fab216252014f685e486f8185b473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Blood Glucose - metabolism</topic><topic>Body Weight - drug effects</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - chemically induced</topic><topic>Diabetes Mellitus, Type 1 - drug therapy</topic><topic>Drinking - drug effects</topic><topic>Eating - drug effects</topic><topic>Glucose Tolerance Test</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Male</topic><topic>Plant Bark - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Trema - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dimo, T.</creatorcontrib><creatorcontrib>Ngueguim, F. T.</creatorcontrib><creatorcontrib>Kamtchouing, P.</creatorcontrib><creatorcontrib>Dongo, E.</creatorcontrib><creatorcontrib>Tan, P. V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Pharmazie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dimo, T.</au><au>Ngueguim, F. T.</au><au>Kamtchouing, P.</au><au>Dongo, E.</au><au>Tan, P. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucose lowering efficacy of the aqueous stem bark extract of Trema orientalis (Linn) Blume in normal and streptozotocin diabetic rats</atitle><jtitle>Pharmazie</jtitle><addtitle>Pharmazie</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>61</volume><issue>3</issue><spage>233</spage><epage>236</epage><pages>233-236</pages><issn>0031-7144</issn><abstract>The glucose-lowering efficacy of the aqueous stem bark extract of Trema orientalis (Ulmaceae) was evaluated both in normal and streptozotocin-induced diabetic rats. In normoglycemic rats, the single oral administration of the aqueous extract of T. orientalis failed to
reduce blood glucose levels while in STZ-diabetic rats, the plant extract (38-300 mg/kg) exhibited significant hypoglycaemic activity with a maximum effect of 29.67%, 5 hours after administration of the 75 mg/kg dose when compared with the diabetic untreated group. Glibenclamide
was not able to lower blood glucose in STZ-diabetic rats, while it significantly lowered the blood sugar in normoglycemic rats. The hypoglycaemic property of T. orientalis was also assessed by an oral glucose tolerance test (OGTT) in STZ-diabetic rats. The aqueous extract of T. orientalis
and the reference drug, glibenclamide, (10 mg/kg) produced significant blood glucose lowering effects in the diabetic rats when compared to the diabetic controls. One week after repeated administration of T. orientalis extract, blood glucose levels were significantly decreased (p <
0.05) and still remained low after 2 weeks (p < 0.01). The results indicated that T. orientalis stem bark extract significantly reduces blood glucose in STZ-induced diabetic rats by a mechanism different from that of sulfonylurea agents. The present investigation provides pharmacological
evidence that the use of this plant extract in traditional medicine for cardiovascular disease can be of benefit particulary in diabetic patients.</abstract><cop>Germany</cop><pub>Govi-Verlag</pub><pmid>16599266</pmid><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; IngentaConnect Free/Open Access Journals |
| subjects | Animals Blood Glucose - metabolism Body Weight - drug effects Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - chemically induced Diabetes Mellitus, Type 1 - drug therapy Drinking - drug effects Eating - drug effects Glucose Tolerance Test Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Male Plant Bark - chemistry Plant Extracts - pharmacology Rats Rats, Wistar Trema - chemistry |
| title | Glucose lowering efficacy of the aqueous stem bark extract of Trema orientalis (Linn) Blume in normal and streptozotocin diabetic rats |
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