Risk factors and the incidence of coronary artery disease in young middle-aged Japanese men: results from a 10-year cohort study
The objective of this study was to elucidate the relationship between risk factors and the coronary artery disease (CAD) in young middle-aged Japanese men. A cohort study of 2,764 young middle-aged Japanese men aged 3544 (mean+/-SD: 42.3+/-2.5) years based on a 10-year followup to identify the risk...
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| Veröffentlicht in: | Internal medicine (Tokyo, 1992) 1992), 2006-01, Vol.45 (5), p.235 |
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| creator | Satoh, Hiroki Nishino, Tetsuo Tomita, Kazuo Saijo, Yasuaki Kishi, Reiko Tsutsui, Hiroyuki |
| description | The objective of this study was to elucidate the relationship between risk factors and the coronary artery disease (CAD) in young middle-aged Japanese men.
A cohort study of 2,764 young middle-aged Japanese men aged 3544 (mean+/-SD: 42.3+/-2.5) years based on a 10-year followup to identify the risk factors for the occurrence of CAD was conducted. There were 35 cases of CAD during the follow up; 25 myocardial infarctions and 10 angina pectoris. The Cox Proportional hazard model was used to identify the independent risk factors for CAD. Adjustment was made for variables including age, body mass index, smoking habit, systolic blood pressure, total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), fasting plasma glucose (FPG), and triglyceride.
TC, low HDLC, and FPG were identified as significant independent risk factors for CAD. Adjusted hazard ratio (HR) of a high level of TC> or = 220 (mg/dl) for CAD was 5.46 (95% confidence interval (CI): 1.9617.51) and that of a high level of HDLC or = 110 (mg/dl) was 2.94 (95%CI: 1.228.23). Considering the combination of these risk factors, adjusted HR for CAD of the subjects who had 2 risk factors was 8.37 (95%CI: 2.2131.65).
Using the database of young middle-aged Japanese men, TC, low HDLC, and FPG were found to be important risk factors for CAD, and the combination of these risk factors was associated with CAD. |
| doi_str_mv | 10.2169/internalmedicine.45.1532 |
| format | Article |
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A cohort study of 2,764 young middle-aged Japanese men aged 3544 (mean+/-SD: 42.3+/-2.5) years based on a 10-year followup to identify the risk factors for the occurrence of CAD was conducted. There were 35 cases of CAD during the follow up; 25 myocardial infarctions and 10 angina pectoris. The Cox Proportional hazard model was used to identify the independent risk factors for CAD. Adjustment was made for variables including age, body mass index, smoking habit, systolic blood pressure, total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), fasting plasma glucose (FPG), and triglyceride.
TC, low HDLC, and FPG were identified as significant independent risk factors for CAD. Adjusted hazard ratio (HR) of a high level of TC> or = 220 (mg/dl) for CAD was 5.46 (95% confidence interval (CI): 1.9617.51) and that of a high level of HDLC<50(mg/dl) was 9.01 (95%CI: 1.1372.17), and a high level of FPG> or = 110 (mg/dl) was 2.94 (95%CI: 1.228.23). Considering the combination of these risk factors, adjusted HR for CAD of the subjects who had 2 risk factors was 8.37 (95%CI: 2.2131.65).
Using the database of young middle-aged Japanese men, TC, low HDLC, and FPG were found to be important risk factors for CAD, and the combination of these risk factors was associated with CAD.</description><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.45.1532</identifier><identifier>PMID: 16595986</identifier><language>eng</language><publisher>Japan</publisher><subject>Adult ; Angina Pectoris - epidemiology ; Blood Glucose - analysis ; Cholesterol - blood ; Cholesterol, HDL - blood ; Confidence Intervals ; Coronary Artery Disease - blood ; Coronary Artery Disease - epidemiology ; Follow-Up Studies ; Humans ; Japan - epidemiology ; Male ; Myocardial Infarction - epidemiology ; Proportional Hazards Models ; Risk Assessment ; Risk Factors</subject><ispartof>Internal medicine (Tokyo, 1992), 2006-01, Vol.45 (5), p.235</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16595986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Satoh, Hiroki</creatorcontrib><creatorcontrib>Nishino, Tetsuo</creatorcontrib><creatorcontrib>Tomita, Kazuo</creatorcontrib><creatorcontrib>Saijo, Yasuaki</creatorcontrib><creatorcontrib>Kishi, Reiko</creatorcontrib><creatorcontrib>Tsutsui, Hiroyuki</creatorcontrib><title>Risk factors and the incidence of coronary artery disease in young middle-aged Japanese men: results from a 10-year cohort study</title><title>Internal medicine (Tokyo, 1992)</title><addtitle>Intern Med</addtitle><description>The objective of this study was to elucidate the relationship between risk factors and the coronary artery disease (CAD) in young middle-aged Japanese men.
A cohort study of 2,764 young middle-aged Japanese men aged 3544 (mean+/-SD: 42.3+/-2.5) years based on a 10-year followup to identify the risk factors for the occurrence of CAD was conducted. There were 35 cases of CAD during the follow up; 25 myocardial infarctions and 10 angina pectoris. The Cox Proportional hazard model was used to identify the independent risk factors for CAD. Adjustment was made for variables including age, body mass index, smoking habit, systolic blood pressure, total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), fasting plasma glucose (FPG), and triglyceride.
TC, low HDLC, and FPG were identified as significant independent risk factors for CAD. Adjusted hazard ratio (HR) of a high level of TC> or = 220 (mg/dl) for CAD was 5.46 (95% confidence interval (CI): 1.9617.51) and that of a high level of HDLC<50(mg/dl) was 9.01 (95%CI: 1.1372.17), and a high level of FPG> or = 110 (mg/dl) was 2.94 (95%CI: 1.228.23). Considering the combination of these risk factors, adjusted HR for CAD of the subjects who had 2 risk factors was 8.37 (95%CI: 2.2131.65).
Using the database of young middle-aged Japanese men, TC, low HDLC, and FPG were found to be important risk factors for CAD, and the combination of these risk factors was associated with CAD.</description><subject>Adult</subject><subject>Angina Pectoris - epidemiology</subject><subject>Blood Glucose - analysis</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Confidence Intervals</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Proportional Hazards Models</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UMlOwzAUtJAQLYVfQO8HUrzETswNIVZVQkJwrhz7uXVJnMpODrnx6QQBpznMaDZCgNE1Z0pfhzhgiqbt0AUbIq5LuWZS8BOyZKLURcWFXJDznA-UirrS_IwsmJJa6lotyddbyJ_gjR36lMFEB8MeIUQbHEaL0HuwfeqjSROYNCdN4EJGk39EMPVj3EEXnGuxMDt08GKOJuLMdhhvIGEe2yGDT30HZq5cTGjS7Ljv0wB5GN10QU69aTNe_uGKfDzcv989FZvXx-e7201x4JQPRaO8RN1o7tAoVaqmlM7rmklmGUfX-MoL62ovlNBU1pp62Uhb6ZqiqHhtxIpc_foex2a-antMoZtHbf-vEN_O7GVB</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Satoh, Hiroki</creator><creator>Nishino, Tetsuo</creator><creator>Tomita, Kazuo</creator><creator>Saijo, Yasuaki</creator><creator>Kishi, Reiko</creator><creator>Tsutsui, Hiroyuki</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20060101</creationdate><title>Risk factors and the incidence of coronary artery disease in young middle-aged Japanese men: results from a 10-year cohort study</title><author>Satoh, Hiroki ; Nishino, Tetsuo ; Tomita, Kazuo ; Saijo, Yasuaki ; Kishi, Reiko ; Tsutsui, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j202t-b6f5e9b92dea6646b45df98151c12edbf7f3cd8f363905890f5b5c7980e3728a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Angina Pectoris - epidemiology</topic><topic>Blood Glucose - analysis</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Confidence Intervals</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Proportional Hazards Models</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Satoh, Hiroki</creatorcontrib><creatorcontrib>Nishino, Tetsuo</creatorcontrib><creatorcontrib>Tomita, Kazuo</creatorcontrib><creatorcontrib>Saijo, Yasuaki</creatorcontrib><creatorcontrib>Kishi, Reiko</creatorcontrib><creatorcontrib>Tsutsui, Hiroyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Internal medicine (Tokyo, 1992)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Satoh, Hiroki</au><au>Nishino, Tetsuo</au><au>Tomita, Kazuo</au><au>Saijo, Yasuaki</au><au>Kishi, Reiko</au><au>Tsutsui, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors and the incidence of coronary artery disease in young middle-aged Japanese men: results from a 10-year cohort study</atitle><jtitle>Internal medicine (Tokyo, 1992)</jtitle><addtitle>Intern Med</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>45</volume><issue>5</issue><spage>235</spage><pages>235-</pages><eissn>1349-7235</eissn><abstract>The objective of this study was to elucidate the relationship between risk factors and the coronary artery disease (CAD) in young middle-aged Japanese men.
A cohort study of 2,764 young middle-aged Japanese men aged 3544 (mean+/-SD: 42.3+/-2.5) years based on a 10-year followup to identify the risk factors for the occurrence of CAD was conducted. There were 35 cases of CAD during the follow up; 25 myocardial infarctions and 10 angina pectoris. The Cox Proportional hazard model was used to identify the independent risk factors for CAD. Adjustment was made for variables including age, body mass index, smoking habit, systolic blood pressure, total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), fasting plasma glucose (FPG), and triglyceride.
TC, low HDLC, and FPG were identified as significant independent risk factors for CAD. Adjusted hazard ratio (HR) of a high level of TC> or = 220 (mg/dl) for CAD was 5.46 (95% confidence interval (CI): 1.9617.51) and that of a high level of HDLC<50(mg/dl) was 9.01 (95%CI: 1.1372.17), and a high level of FPG> or = 110 (mg/dl) was 2.94 (95%CI: 1.228.23). Considering the combination of these risk factors, adjusted HR for CAD of the subjects who had 2 risk factors was 8.37 (95%CI: 2.2131.65).
Using the database of young middle-aged Japanese men, TC, low HDLC, and FPG were found to be important risk factors for CAD, and the combination of these risk factors was associated with CAD.</abstract><cop>Japan</cop><pmid>16595986</pmid><doi>10.2169/internalmedicine.45.1532</doi></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1349-7235 |
| ispartof | Internal medicine (Tokyo, 1992), 2006-01, Vol.45 (5), p.235 |
| issn | 1349-7235 |
| language | eng |
| recordid | cdi_pubmed_primary_16595986 |
| source | J-STAGE Free; MEDLINE |
| subjects | Adult Angina Pectoris - epidemiology Blood Glucose - analysis Cholesterol - blood Cholesterol, HDL - blood Confidence Intervals Coronary Artery Disease - blood Coronary Artery Disease - epidemiology Follow-Up Studies Humans Japan - epidemiology Male Myocardial Infarction - epidemiology Proportional Hazards Models Risk Assessment Risk Factors |
| title | Risk factors and the incidence of coronary artery disease in young middle-aged Japanese men: results from a 10-year cohort study |
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