Modulation of γ‐Aminobutyric AcidA Receptor‐Operated Chloride Channels by Benzodiazepine Inverse Agonists Is Related to Genetic Differences in Ethanol Withdrawal Seizure Severity

To determine whether genetic differences in development of ethanol dependence are related to changes in γ‐aminobutyric acidA (GABAA) receptor function, we measured 36Cl uptake by brain cortical membrane vesicles from withdrawal seizure prone and withdrawal seizure resistant (WSP/WSR) mice treated ch...

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Veröffentlicht in:	Journal of neurochemistry 1991-12, Vol.57 (6), p.2100-2105
Hauptverfasser:	Buck, Kari J., McQuilkin, Susan J., Harris, R. Adron
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcoholism and acute alcohol poisoning Animals Benzodiazepines - metabolism Biological and medical sciences Buck K. J. et al. Modulation of γ‐aminobutyric acidA receptor‐operated chloride channels by benzodiazepine inverse agonists is related to genetic differences in ethanol withdrawal seizure severity Carbolines - pharmacology Chloride Channels Chlorides - pharmacokinetics Convulsants - pharmacology Ethanol - adverse effects Flunitrazepam - pharmacology GABA—Ethanol—Benzodiazepines—Genetics—Alcohol dependence—Seizures Genetic Predisposition to Disease Male Medical sciences Membrane Proteins - metabolism Mice Mice, Inbred Strains Muscimol - pharmacology Receptors, GABA-A - physiology Seizures - genetics Seizures - physiopathology Substance Withdrawal Syndrome - genetics Substance Withdrawal Syndrome - physiopathology Toxicology
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