Application of UL144 Molecular Typing To Determine Epidemiology of Cytomegalovirus Infections in Preterm Infants

Sequence analysis of the UL144 gene of human cytomegalovirus (CMV) was used to investigate the epidemiology of CMV infections in preterm infants. Nosocomial transmission of CMV from congenitally infected infant to preterm twins was excluded based on distinct molecular profiles of CMV strains. Indist...

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Veröffentlicht in:	Journal of Clinical Microbiology 2006-03, Vol.44 (3), p.1108-1110
Hauptverfasser:	Stranska, R, Schuurman, R, Toet, M, Verboon-Maciolek, M, de Vries, L. S, van Loon, A. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Breast Feeding - adverse effects Cross Infection - epidemiology Cross Infection - transmission Cross Infection - virology Cytomegalovirus - classification Cytomegalovirus - genetics Cytomegalovirus - isolation & purification Cytomegalovirus Infections - epidemiology Cytomegalovirus Infections - transmission Cytomegalovirus Infections - virology DNA Primers - genetics DNA, Viral - genetics Female Fundamental and applied biological sciences. Psychology Genes, Viral Genotype Human cytomegalovirus Humans Infant, Newborn Infant, Premature Infectious diseases Medical sciences Membrane Glycoproteins - genetics Microbiology Milk, Human - virology Molecular Epidemiology Netherlands - epidemiology Viral Proteins - genetics Virology
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Zusammenfassung:	Sequence analysis of the UL144 gene of human cytomegalovirus (CMV) was used to investigate the epidemiology of CMV infections in preterm infants. Nosocomial transmission of CMV from congenitally infected infant to preterm twins was excluded based on distinct molecular profiles of CMV strains. Indistinguishable molecular profiles between strains from the mother and the infant indicated postnatal acquisition of CMV through breastfeeding.
ISSN:	0095-1137 1098-660X 1098-5530
DOI:	10.1128/JCM.44.3.1108-1110.2006