Lipoteichoic acid induces prostaglandin E(2) release and cyclooxygenase-2 synthesis in rat cortical neuronal cells: involvement of PKCepsilon and ERK activation

Inflammatory processes occur in the central nervous system (CNS) through mechanisms that differ from other inflammation, and with distinct cellular effects. Neuronal injury in bacterial meningitis is not a monocausal event, but is mediated by several factors. One is possible direct toxicity of bacte...

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Veröffentlicht in:	Life sciences (1973) 2006-06, Vol.79 (3), p.272
Hauptverfasser:	Wu, Hsueh-Hsia, Hsieh, Wen-Shyang, Yang, Yi-Yuan, Tsai, Ming-Chuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cerebral Cortex - cytology Cerebral Cortex - drug effects Cerebral Cortex - enzymology Cyclooxygenase 2 - analysis Cyclooxygenase 2 - biosynthesis Dinoprostone - analysis Dinoprostone - metabolism Enzyme Activation Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - metabolism Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Lipopolysaccharides - toxicity Neurons - chemistry Neurons - drug effects Neurons - enzymology Protein Kinase C-epsilon - antagonists & inhibitors Protein Kinase C-epsilon - metabolism Protein Kinase Inhibitors - pharmacology Protein Transport Rats Rats, Sprague-Dawley Teichoic Acids - toxicity
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