Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor

We report the definition and characterization of a conotoxin subfamily, designated the short alphaA-conotoxins (alphaA(S)) and demonstrate that all of these share the unique property of selectively antagonizing the fetal subtype of the mammalian neuromuscular nicotinic acetylcholine receptor (nAChR)...

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Veröffentlicht in:	Biochemistry (Easton) 2006-01, Vol.45 (4), p.1304
Hauptverfasser:	Teichert, Russell W, López-Vera, Estuardo, Gulyas, Jozsef, Watkins, Maren, Rivier, Jean, Olivera, Baldomero M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Cloning, Molecular Conotoxins - antagonists & inhibitors Conotoxins - chemistry Conotoxins - metabolism Conus Snail - cytology Conus Snail - metabolism Humans Kinetics Mice Molecular Sequence Data Muscles - embryology Muscles - metabolism Peptides, Cyclic - antagonists & inhibitors Rats Receptors, Nicotinic - chemistry Receptors, Nicotinic - metabolism Time Factors Xenopus - metabolism
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