Homocysteine-Induced Endothelin-1 Release Is Dependent on Hyperglycaemia and Reactive Oxygen Species Production in Bovine Aortic Endothelial Cells

Background: Elevated plasma homocysteine (Hcy) is a risk factor for coronary disease. The objective of this study was to investigate whether Hcy either alone or in high glucose conditions induces endothelin-1 (ET-1) synthesis via the production of reactive oxygen species (ROS). Methods: Bovine aorti...

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Veröffentlicht in:	Journal of vascular research 2006-01, Vol.43 (2), p.175-183
Hauptverfasser:	Sethi, Amarjit S., Lees, Delphine M., Douthwaite, Julie A., Dawnay, Anne B., Corder, Roger
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - cytology Biological and medical sciences Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology Cattle Cells, Cultured Electron Transport Complex II - antagonists & inhibitors Endothelin-1 - secretion Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Fundamental and applied biological sciences. Psychology Glucose - administration & dosage Glutathione - metabolism Homocysteine - pharmacology Hyperglycemia - physiopathology Oxidative Stress - physiology Reactive Oxygen Species - metabolism Research Paper Thenoyltrifluoroacetone - pharmacology Thromboplastin - metabolism Uncoupling Agents - pharmacology Vertebrates: cardiovascular system
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