Azidothymidine-induced cytotoxicity and incorporation into DNA in the human colon tumor cell line HCT-8 is enhanced by methotrexate in vitro and in vivo

We have reported that 5-fluorouracil can increase the cytotoxic and antineoplastic activity of 3'-azido-3'-deoxythymidine (AZT). To further evaluate the antineoplastic utility of AZT we now have assessed its effect in combination with methotrexate (MTX) in the human colon tumor model HCT-8...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1992-08, Vol.52 (15), p.4069-4073
Hauptverfasser:	TOSI, P, CALABRESI, P, GOULETTE, F. A, RENAUD, C. A, DARNOWSKI, J. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Biotransformation Cell Line Cell Survival - drug effects Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism DNA, Neoplasm - metabolism General aspects Humans Medical sciences Methotrexate - pharmacology Methotrexate - therapeutic use Mice Mice, Nude Neoplasm Transplantation Pharmacology. Drug treatments Thymidylate Synthase - metabolism Transplantation, Heterologous Zidovudine - metabolism Zidovudine - pharmacology Zidovudine - therapeutic use
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