The Identification and Characterization of Two Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatases

Numerous inositol polyphosphate 5-phosphatases catalyze the degradation of phosphatidylinositol-4,5-bisphosphate ($PtdIns-4,5-P_2$) to phosphatidylinositol-4-phosphate (PtdIns-4-P). An alternative pathway to degrade$PtdIns-4,5-P_2$is the hydrolysis of$PtdIns-4,5-P_2$by a 4-phosphatase, leading to th...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-12, Vol.102 (52), p.18854-18859
Hauptverfasser:	Ungewickell, Alexander, Christopher Hugge, Marina Kisseleva, Shao-Chun Chang, Zou, Jun, Feng, Yucheng, Galyov, Edouard E., Monita Wilson, Majerus, Philip W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Animals Antibodies Biochemistry Biological Sciences Blotting, Northern Burkholderia pseudomallei - metabolism Catalysis Cell Line Cercopithecus aethiops Cloning, Molecular COS Cells DNA, Complementary - metabolism Endosomes - metabolism Enzymes Epidermal Growth Factor - metabolism Epithelial cells Fluorescent Dyes - pharmacology Green Fluorescent Proteins - metabolism HEK293 cells HeLa Cells Humans Hydrolysis Inositol Polyphosphate 5-Phosphatases Inositols Lipids Lysosomes - metabolism Microscopy, Fluorescence Molecular Sequence Data Phosphatases Phosphates Phosphatidylinositol Phosphates - chemistry Phosphatidylinositol Phosphates - metabolism Phosphatidylinositols Phosphatidylinositols - chemistry Phosphoric Monoester Hydrolases - chemistry Phosphoric Monoester Hydrolases - metabolism Polyphosphates Receptor, Epidermal Growth Factor - metabolism RNA, Messenger - metabolism RNA, Small Interfering - metabolism Sequence Homology, Amino Acid Signal Transduction Time Factors Tissue Distribution Transfection
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