Blockade of interleukin-13-mediated cell activation by a novel inhibitory antibody to human IL-13 receptor alpha1

Interleukin-13 (IL-13) is a cytokine with a crucial role in the development of allergic asthma. The IL-13 receptor shares the IL-4Ralpha subunit with the IL-4R system, but contains as a specific component the IL-13Ralpha1 chain. Blocking signal release by IL-13 without affecting IL-4 function is a p...

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Veröffentlicht in:	Molecular immunology 2006-04, Vol.43 (11), p.1799
Hauptverfasser:	Krause, Sebastian, Behrends, Jochen, Borowski, Andreas, Lohrmann, Jens, Lang, Stefan, Myrtek, Daniel, Lorenzen, Thomas, Virchow, J Christian, Luttmann, Werner, Friedrich, Karlheinz
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antibody Specificity - immunology Arachidonate 15-Lipoxygenase - metabolism Binding Sites, Antibody - immunology Cell Line, Tumor Dose-Response Relationship, Drug Humans Hybridomas Inhibitory Concentration 50 Interleukin-13 - antagonists & inhibitors Interleukin-13 - immunology Interleukin-13 Receptor alpha1 Subunit Monocytes - cytology Monocytes - drug effects Monocytes - enzymology Monocytes - immunology Phosphotyrosine Receptors, Interleukin - antagonists & inhibitors Receptors, Interleukin - metabolism Receptors, Interleukin-13 STAT6 Transcription Factor - metabolism Time Factors
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