Oleoylethanolamide Protects Human Sperm Cells from Oxidation Stress: Studies on Cases of Idiopathic Infertility
N-acylethanolamides are naturally occurring hydrophobic molecules usually present in a very small amount in many mammalian tissues and cells. The presence of N-acylethanolamides has also been demonstrated in human reproductive tracts and fluids, although their biological effects and molecular mechan...
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| Veröffentlicht in: | Biology of reproduction 2006-04, Vol.74 (4), p.659-665 |
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| creator | Ambrosini, Annarina Zolese, Giovanna Ambrosi, Simona Ragni, Letizia Tiano, Luca Littarru, Gianpaolo Bertoli, Enrico Mantero, Franco Boscaro, Marco Balercia, Giancarlo |
| description | N-acylethanolamides are naturally occurring hydrophobic molecules usually present in a very small amount in many mammalian tissues and cells. The presence of N-acylethanolamides has also been demonstrated in human reproductive tracts and fluids, although their biological effects and molecular mechanisms of action are not yet completely elucidated. It is known that some N-acylethanolamides, such as oleoylethanolamide, have antioxidative properties. The aim of this study was to test whether oleoylethanolamide could protect sperm cells from reactive oxygen species-induced oxidative damage in cases of idiopathic infertility, because the excessive generation of these radicals was associated with this pathology. Our results show that 2.5 nM oleoylethanolamide in vitro supplementation significantly reduces DNA strand breaks both in fertile and infertile subjects. Moreover, oleoylethanolamide increases kinematic parameters, such as curvilinear velocity and amplitude of lateral head displacement and hyperactivation, both in the presence and in the absence of oxidative stress. Results of this study support the hypothesis of a possible protective action of oleoylethanolamide against reactive oxygen species, which could explain its beneficial effects on in vitro capacitated spermatozoa. |
| doi_str_mv | 10.1095/biolreprod.105.046060 |
| format | Article |
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The presence of N-acylethanolamides has also been demonstrated in human reproductive tracts and fluids, although their biological effects and molecular mechanisms of action are not yet completely elucidated. It is known that some N-acylethanolamides, such as oleoylethanolamide, have antioxidative properties. The aim of this study was to test whether oleoylethanolamide could protect sperm cells from reactive oxygen species-induced oxidative damage in cases of idiopathic infertility, because the excessive generation of these radicals was associated with this pathology. Our results show that 2.5 nM oleoylethanolamide in vitro supplementation significantly reduces DNA strand breaks both in fertile and infertile subjects. Moreover, oleoylethanolamide increases kinematic parameters, such as curvilinear velocity and amplitude of lateral head displacement and hyperactivation, both in the presence and in the absence of oxidative stress. Results of this study support the hypothesis of a possible protective action of oleoylethanolamide against reactive oxygen species, which could explain its beneficial effects on in vitro capacitated spermatozoa.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod.105.046060</identifier><identifier>PMID: 16354794</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction, Inc</publisher><subject>2-Naphthylamine - analogs & derivatives ; Adult ; Biological and medical sciences ; Cell Membrane ; Comet Assay ; DNA Damage ; Endocannabinoids ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Hydrogen Peroxide ; Infertility, Male - physiopathology ; Laurates ; Male ; Mammalian male genital system ; Morphology. Physiology ; Oleic Acids - pharmacology ; Oxidative Stress - drug effects ; Semen - physiology ; Spectrometry, Fluorescence ; Sperm Capacitation ; Spermatozoa - drug effects ; Vertebrates: reproduction</subject><ispartof>Biology of reproduction, 2006-04, Vol.74 (4), p.659-665</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17642144$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16354794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ambrosini, Annarina</creatorcontrib><creatorcontrib>Zolese, Giovanna</creatorcontrib><creatorcontrib>Ambrosi, Simona</creatorcontrib><creatorcontrib>Ragni, Letizia</creatorcontrib><creatorcontrib>Tiano, Luca</creatorcontrib><creatorcontrib>Littarru, Gianpaolo</creatorcontrib><creatorcontrib>Bertoli, Enrico</creatorcontrib><creatorcontrib>Mantero, Franco</creatorcontrib><creatorcontrib>Boscaro, Marco</creatorcontrib><creatorcontrib>Balercia, Giancarlo</creatorcontrib><title>Oleoylethanolamide Protects Human Sperm Cells from Oxidation Stress: Studies on Cases of Idiopathic Infertility</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>N-acylethanolamides are naturally occurring hydrophobic molecules usually present in a very small amount in many mammalian tissues and cells. The presence of N-acylethanolamides has also been demonstrated in human reproductive tracts and fluids, although their biological effects and molecular mechanisms of action are not yet completely elucidated. It is known that some N-acylethanolamides, such as oleoylethanolamide, have antioxidative properties. The aim of this study was to test whether oleoylethanolamide could protect sperm cells from reactive oxygen species-induced oxidative damage in cases of idiopathic infertility, because the excessive generation of these radicals was associated with this pathology. Our results show that 2.5 nM oleoylethanolamide in vitro supplementation significantly reduces DNA strand breaks both in fertile and infertile subjects. Moreover, oleoylethanolamide increases kinematic parameters, such as curvilinear velocity and amplitude of lateral head displacement and hyperactivation, both in the presence and in the absence of oxidative stress. Results of this study support the hypothesis of a possible protective action of oleoylethanolamide against reactive oxygen species, which could explain its beneficial effects on in vitro capacitated spermatozoa.</description><subject>2-Naphthylamine - analogs & derivatives</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cell Membrane</subject><subject>Comet Assay</subject><subject>DNA Damage</subject><subject>Endocannabinoids</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hydrogen Peroxide</subject><subject>Infertility, Male - physiopathology</subject><subject>Laurates</subject><subject>Male</subject><subject>Mammalian male genital system</subject><subject>Morphology. Physiology</subject><subject>Oleic Acids - pharmacology</subject><subject>Oxidative Stress - drug effects</subject><subject>Semen - physiology</subject><subject>Spectrometry, Fluorescence</subject><subject>Sperm Capacitation</subject><subject>Spermatozoa - drug effects</subject><subject>Vertebrates: reproduction</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNj81qGzEUhUVoSdykj9BWmyzHlXRnNFZ3xTSNIeBAkvWgGV3ZKhprkGRcv31U7JKszv35OJxDyBfO5pyp5nvvgo84xWDK3sxZLZlkF2TGG6GqVsjFBzJjjMkKQMIV-ZTSH8Z4DQIuyRWX0NStqmckrD2Go8e81bvg9egM0scYMg450fv9qHf0acI40iV6n6iNYaTrv87o7EJ55Ygp_Si6Nw4TLaelTv8GS1fGhUnnrRvoamcxZuddPt6Qj1b7hJ_Pek1e7n49L--rh_Xv1fLnQ2WFglwBR2ksVyAXvWwsghWDUXoQC6WUbgdgKBs1QCnXioYLZL1lpu0BWjQSergmX0--074f0XRTdKOOx-5_8wLcngGdBu1t1LvBpTeulbXg9Ttu6zbbg4vYpVF7X2yhOxwObd3VXYlSuG8nzurQ6U0sXi9PgnFgnElQjYRXr5iCSA</recordid><startdate>20060401</startdate><enddate>20060401</enddate><creator>Ambrosini, Annarina</creator><creator>Zolese, Giovanna</creator><creator>Ambrosi, Simona</creator><creator>Ragni, Letizia</creator><creator>Tiano, Luca</creator><creator>Littarru, Gianpaolo</creator><creator>Bertoli, Enrico</creator><creator>Mantero, Franco</creator><creator>Boscaro, Marco</creator><creator>Balercia, Giancarlo</creator><general>Society for the Study of Reproduction, Inc</general><general>Society for the Study of Reproduction</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20060401</creationdate><title>Oleoylethanolamide Protects Human Sperm Cells from Oxidation Stress: Studies on Cases of Idiopathic Infertility</title><author>Ambrosini, Annarina ; Zolese, Giovanna ; Ambrosi, Simona ; Ragni, Letizia ; Tiano, Luca ; Littarru, Gianpaolo ; Bertoli, Enrico ; Mantero, Franco ; Boscaro, Marco ; Balercia, Giancarlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f293t-31e6df19368b65fe3f2cd9ac28999a7c30e659c333672512e0bf0d7b337ed63b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>2-Naphthylamine - analogs & derivatives</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cell Membrane</topic><topic>Comet Assay</topic><topic>DNA Damage</topic><topic>Endocannabinoids</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hydrogen Peroxide</topic><topic>Infertility, Male - physiopathology</topic><topic>Laurates</topic><topic>Male</topic><topic>Mammalian male genital system</topic><topic>Morphology. Physiology</topic><topic>Oleic Acids - pharmacology</topic><topic>Oxidative Stress - drug effects</topic><topic>Semen - physiology</topic><topic>Spectrometry, Fluorescence</topic><topic>Sperm Capacitation</topic><topic>Spermatozoa - drug effects</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ambrosini, Annarina</creatorcontrib><creatorcontrib>Zolese, Giovanna</creatorcontrib><creatorcontrib>Ambrosi, Simona</creatorcontrib><creatorcontrib>Ragni, Letizia</creatorcontrib><creatorcontrib>Tiano, Luca</creatorcontrib><creatorcontrib>Littarru, Gianpaolo</creatorcontrib><creatorcontrib>Bertoli, Enrico</creatorcontrib><creatorcontrib>Mantero, Franco</creatorcontrib><creatorcontrib>Boscaro, Marco</creatorcontrib><creatorcontrib>Balercia, Giancarlo</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ambrosini, Annarina</au><au>Zolese, Giovanna</au><au>Ambrosi, Simona</au><au>Ragni, Letizia</au><au>Tiano, Luca</au><au>Littarru, Gianpaolo</au><au>Bertoli, Enrico</au><au>Mantero, Franco</au><au>Boscaro, Marco</au><au>Balercia, Giancarlo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oleoylethanolamide Protects Human Sperm Cells from Oxidation Stress: Studies on Cases of Idiopathic Infertility</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>2006-04-01</date><risdate>2006</risdate><volume>74</volume><issue>4</issue><spage>659</spage><epage>665</epage><pages>659-665</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>N-acylethanolamides are naturally occurring hydrophobic molecules usually present in a very small amount in many mammalian tissues and cells. The presence of N-acylethanolamides has also been demonstrated in human reproductive tracts and fluids, although their biological effects and molecular mechanisms of action are not yet completely elucidated. It is known that some N-acylethanolamides, such as oleoylethanolamide, have antioxidative properties. The aim of this study was to test whether oleoylethanolamide could protect sperm cells from reactive oxygen species-induced oxidative damage in cases of idiopathic infertility, because the excessive generation of these radicals was associated with this pathology. Our results show that 2.5 nM oleoylethanolamide in vitro supplementation significantly reduces DNA strand breaks both in fertile and infertile subjects. Moreover, oleoylethanolamide increases kinematic parameters, such as curvilinear velocity and amplitude of lateral head displacement and hyperactivation, both in the presence and in the absence of oxidative stress. Results of this study support the hypothesis of a possible protective action of oleoylethanolamide against reactive oxygen species, which could explain its beneficial effects on in vitro capacitated spermatozoa.</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction, Inc</pub><pmid>16354794</pmid><doi>10.1095/biolreprod.105.046060</doi><tpages>7</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; BioOne Complete |
| subjects | 2-Naphthylamine - analogs & derivatives Adult Biological and medical sciences Cell Membrane Comet Assay DNA Damage Endocannabinoids Female Fundamental and applied biological sciences. Psychology Humans Hydrogen Peroxide Infertility, Male - physiopathology Laurates Male Mammalian male genital system Morphology. Physiology Oleic Acids - pharmacology Oxidative Stress - drug effects Semen - physiology Spectrometry, Fluorescence Sperm Capacitation Spermatozoa - drug effects Vertebrates: reproduction |
| title | Oleoylethanolamide Protects Human Sperm Cells from Oxidation Stress: Studies on Cases of Idiopathic Infertility |
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