Effect of five nights of normobaric hypoxia on cardiovascular responses to acute isocapnic hypoxia in humans: relationship to ventilatory chemosensitivity
The aim of this study was to elucidate (1) the cardiovascular responses to acute isocapnic hypoxia stimuli following five nights of normobaric poikilocapnic hypoxia, and (2) whether the changes in the cardiovascular responses to hypoxia are correlated to the change in acute hypoxic ventilatory (AHVR...
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| Veröffentlicht in: | Ergonomics 2005-09, Vol.48 (11-14), p.1523-1534 |
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| creator | Ainslie, Philip N. Kolb, Jon C. Ide, Kojiro Poulin, Marc J. |
| description | The aim of this study was to elucidate (1) the cardiovascular responses to acute isocapnic hypoxia stimuli following five nights of normobaric poikilocapnic hypoxia, and (2) whether the changes in the cardiovascular responses to hypoxia are correlated to the change in acute hypoxic ventilatory (AHVR) chemosensitivity. Twelve male subjects [26.6 ± 4.1 (SD) years] slept 8-9 h day
−1
overnight for five consecutive days at a simulated altitude of 4300 m (FiO
2
= ∼13.8%). Using the technique of dynamic end-tidal forcing, the AHVR was assessed twice, prior to and immediately after the hypoxic exposure. During each AHVR test, mean arterial blood pressure (MAP) and heart rate (HR) were measured continuously using finger photoplethysmography and an ECG monitor, respectively. Immediately following the exposure, AHVR and MAP sensitivities were increased by 1.80 ± 1.30 l min
−1
%
−1
(p |
| doi_str_mv | 10.1080/00140130500101403 |
| format | Article |
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−1
overnight for five consecutive days at a simulated altitude of 4300 m (FiO
2
= ∼13.8%). Using the technique of dynamic end-tidal forcing, the AHVR was assessed twice, prior to and immediately after the hypoxic exposure. During each AHVR test, mean arterial blood pressure (MAP) and heart rate (HR) were measured continuously using finger photoplethysmography and an ECG monitor, respectively. Immediately following the exposure, AHVR and MAP sensitivities were increased by 1.80 ± 1.30 l min
−1
%
−1
(p < 0.01) and 0.69 ± 0.40 mmHg %
−1
(p < 0.05), respectively, and there were significant correlations between the increases in the AHVR and MAP sensitivities (r = 0.67; p < 0.05). In summary, following five nights of normobaric hypoxia, there is an enhanced MAP response to hypoxic stimuli. The relationship between the enhanced AHVR and MAP sensitivity raises the possibility of a common pathway in the regulation of peripheral chemosensitivity and MAP responses during periods of isocapnic hypoxia.</description><identifier>ISSN: 0014-0139</identifier><identifier>EISSN: 1366-5847</identifier><identifier>DOI: 10.1080/00140130500101403</identifier><identifier>PMID: 16338718</identifier><identifier>CODEN: ERGOAX</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Adult ; Altitude ; Blood Pressure ; Chemoreceptor Cells - physiology ; Chemoreceptors ; Heart ; Heart Rate ; Human factors research ; Humans ; Hypoxia - physiopathology ; Male ; Monitoring, Physiologic ; Pulmonary Ventilation - physiology ; Respiratory system ; Space life sciences ; Time Factors ; Ventilation</subject><ispartof>Ergonomics, 2005-09, Vol.48 (11-14), p.1523-1534</ispartof><rights>Copyright Taylor & Francis Group, LLC 2005</rights><rights>Copyright Taylor & Francis Group Sep 15-Nov 15, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-9696591c82a6c47ad4ae8732689a8a91cb4f39f7fa03e20de714187f7f1a09393</citedby><cites>FETCH-LOGICAL-c458t-9696591c82a6c47ad4ae8732689a8a91cb4f39f7fa03e20de714187f7f1a09393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00140130500101403$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00140130500101403$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,60409</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16338718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ainslie, Philip N.</creatorcontrib><creatorcontrib>Kolb, Jon C.</creatorcontrib><creatorcontrib>Ide, Kojiro</creatorcontrib><creatorcontrib>Poulin, Marc J.</creatorcontrib><title>Effect of five nights of normobaric hypoxia on cardiovascular responses to acute isocapnic hypoxia in humans: relationship to ventilatory chemosensitivity</title><title>Ergonomics</title><addtitle>Ergonomics</addtitle><description>The aim of this study was to elucidate (1) the cardiovascular responses to acute isocapnic hypoxia stimuli following five nights of normobaric poikilocapnic hypoxia, and (2) whether the changes in the cardiovascular responses to hypoxia are correlated to the change in acute hypoxic ventilatory (AHVR) chemosensitivity. Twelve male subjects [26.6 ± 4.1 (SD) years] slept 8-9 h day
−1
overnight for five consecutive days at a simulated altitude of 4300 m (FiO
2
= ∼13.8%). Using the technique of dynamic end-tidal forcing, the AHVR was assessed twice, prior to and immediately after the hypoxic exposure. During each AHVR test, mean arterial blood pressure (MAP) and heart rate (HR) were measured continuously using finger photoplethysmography and an ECG monitor, respectively. Immediately following the exposure, AHVR and MAP sensitivities were increased by 1.80 ± 1.30 l min
−1
%
−1
(p < 0.01) and 0.69 ± 0.40 mmHg %
−1
(p < 0.05), respectively, and there were significant correlations between the increases in the AHVR and MAP sensitivities (r = 0.67; p < 0.05). In summary, following five nights of normobaric hypoxia, there is an enhanced MAP response to hypoxic stimuli. The relationship between the enhanced AHVR and MAP sensitivity raises the possibility of a common pathway in the regulation of peripheral chemosensitivity and MAP responses during periods of isocapnic hypoxia.</description><subject>Adult</subject><subject>Altitude</subject><subject>Blood Pressure</subject><subject>Chemoreceptor Cells - physiology</subject><subject>Chemoreceptors</subject><subject>Heart</subject><subject>Heart Rate</subject><subject>Human factors research</subject><subject>Humans</subject><subject>Hypoxia - physiopathology</subject><subject>Male</subject><subject>Monitoring, Physiologic</subject><subject>Pulmonary Ventilation - physiology</subject><subject>Respiratory system</subject><subject>Space life sciences</subject><subject>Time Factors</subject><subject>Ventilation</subject><issn>0014-0139</issn><issn>1366-5847</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EokPhAdggiwW7gB0n_kFsUFVapEpsYB3dcWziKrGD7QzNq_C0OJqRQFSoK9-f7xxd6yD0kpK3lEjyjhDaEMpIW4qtZI_QjjLOq1Y24jHabfuqAOoMPUvptrSMqvopOqOcMSmo3KFfl9YanXGw2LqDwd59H3LaWh_iFPYQncbDOoc7Bzh4rCH2Lhwg6WWEiKNJc_DJJJwDBr1kg10KGmb_l8x5PCwT-PS-8CNkVxSDmzfJwfjsyijEFevBTCEZn1x2B5fX5-iJhTGZF6f3HH37dPn14rq6-XL1-eLjTaWbVuZKccVbRbWsgetGQN-AkYLVXCqQUBb7xjJlhQXCTE16I2hDpSgDCkQxxc7Rm6PvHMOPxaTcTS5pM47gTVhSx6WUNWnZgyAVjSx-G_j6H_A2LNGXT3Q1kYpw1tIC0SOkY0gpGtvN0U0Q146Sbou3uxdv0bw6GS_7yfR_FKc8CyCOgPO25Ac_Qxz7LsM6hmgjeO3Sfdsu3-Wi_PCgkv3_st-hMMeg</recordid><startdate>20050915</startdate><enddate>20050915</enddate><creator>Ainslie, Philip N.</creator><creator>Kolb, Jon C.</creator><creator>Ide, Kojiro</creator><creator>Poulin, Marc J.</creator><general>Taylor & Francis</general><general>Taylor & Francis LLC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T2</scope><scope>7TA</scope><scope>7TB</scope><scope>7TS</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20050915</creationdate><title>Effect of five nights of normobaric hypoxia on cardiovascular responses to acute isocapnic hypoxia in humans: relationship to ventilatory chemosensitivity</title><author>Ainslie, Philip N. ; Kolb, Jon C. ; Ide, Kojiro ; Poulin, Marc J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-9696591c82a6c47ad4ae8732689a8a91cb4f39f7fa03e20de714187f7f1a09393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Altitude</topic><topic>Blood Pressure</topic><topic>Chemoreceptor Cells - physiology</topic><topic>Chemoreceptors</topic><topic>Heart</topic><topic>Heart Rate</topic><topic>Human factors research</topic><topic>Humans</topic><topic>Hypoxia - physiopathology</topic><topic>Male</topic><topic>Monitoring, Physiologic</topic><topic>Pulmonary Ventilation - physiology</topic><topic>Respiratory system</topic><topic>Space life sciences</topic><topic>Time Factors</topic><topic>Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ainslie, Philip N.</creatorcontrib><creatorcontrib>Kolb, Jon C.</creatorcontrib><creatorcontrib>Ide, Kojiro</creatorcontrib><creatorcontrib>Poulin, Marc J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Physical Education Index</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Ergonomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ainslie, Philip N.</au><au>Kolb, Jon C.</au><au>Ide, Kojiro</au><au>Poulin, Marc J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of five nights of normobaric hypoxia on cardiovascular responses to acute isocapnic hypoxia in humans: relationship to ventilatory chemosensitivity</atitle><jtitle>Ergonomics</jtitle><addtitle>Ergonomics</addtitle><date>2005-09-15</date><risdate>2005</risdate><volume>48</volume><issue>11-14</issue><spage>1523</spage><epage>1534</epage><pages>1523-1534</pages><issn>0014-0139</issn><eissn>1366-5847</eissn><coden>ERGOAX</coden><abstract>The aim of this study was to elucidate (1) the cardiovascular responses to acute isocapnic hypoxia stimuli following five nights of normobaric poikilocapnic hypoxia, and (2) whether the changes in the cardiovascular responses to hypoxia are correlated to the change in acute hypoxic ventilatory (AHVR) chemosensitivity. Twelve male subjects [26.6 ± 4.1 (SD) years] slept 8-9 h day
−1
overnight for five consecutive days at a simulated altitude of 4300 m (FiO
2
= ∼13.8%). Using the technique of dynamic end-tidal forcing, the AHVR was assessed twice, prior to and immediately after the hypoxic exposure. During each AHVR test, mean arterial blood pressure (MAP) and heart rate (HR) were measured continuously using finger photoplethysmography and an ECG monitor, respectively. Immediately following the exposure, AHVR and MAP sensitivities were increased by 1.80 ± 1.30 l min
−1
%
−1
(p < 0.01) and 0.69 ± 0.40 mmHg %
−1
(p < 0.05), respectively, and there were significant correlations between the increases in the AHVR and MAP sensitivities (r = 0.67; p < 0.05). In summary, following five nights of normobaric hypoxia, there is an enhanced MAP response to hypoxic stimuli. The relationship between the enhanced AHVR and MAP sensitivity raises the possibility of a common pathway in the regulation of peripheral chemosensitivity and MAP responses during periods of isocapnic hypoxia.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>16338718</pmid><doi>10.1080/00140130500101403</doi><tpages>12</tpages></addata></record> |
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| ispartof | Ergonomics, 2005-09, Vol.48 (11-14), p.1523-1534 |
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| language | eng |
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| source | MEDLINE; Taylor & Francis Journals Complete |
| subjects | Adult Altitude Blood Pressure Chemoreceptor Cells - physiology Chemoreceptors Heart Heart Rate Human factors research Humans Hypoxia - physiopathology Male Monitoring, Physiologic Pulmonary Ventilation - physiology Respiratory system Space life sciences Time Factors Ventilation |
| title | Effect of five nights of normobaric hypoxia on cardiovascular responses to acute isocapnic hypoxia in humans: relationship to ventilatory chemosensitivity |
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